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Clenbuterol is a long acting, selective beta 2 receptor agonist. So let’s take a look at what that means. Long acting is fairly self-explanatory. Selective means it targets specific beta receptor sites. The beta 2 receptor is responsible for several things but is heavily present in the respiratory system. An agonist (in this case) is a substance that bonds to the receptor of a cell triggering some form of response, quite often it mimics a naturally occurring substance with the organism.
So let’s put that all together. Clenbuterol bonds to the beta 2 receptor and triggers a response. So what is that response? Well beta 2 receptor activation results in the production of cyclic adenosine monophosphate (cAMP). CAMP then results in an activation of protein kinease A (PKA). PKA has several functions including sugar metabolism, lipid metabolism, and glycogen regulation. Also beta 2 activation results in a decrease in intracellular calcium and an increase in potassium flow (Perhaps why in our research we may observe cramping?)
So all that sounds great and we could go very in depth with how these reactions occur to an even more minute level but let’s focus on what this beta 2 receptor activation ultimately does. Ultimately there are several effects that occur from this beta 2 receptor activation:
1: Blood vessel dilation (relaxation of smooth muscle)
2: Bronchodilation
3: Increase in metabolic activity
4: Increase in core temperature
5: Increase in basal metabolic rate
These effects provide some interesting results in our research.
1: It has been found that clenbuterol has the unique ability to preserve muscle in a state of caloric deficit while increasing the metabolism of fat.
2: It was also observed that clenbuterol has the ability to reverse muscle wasting.
3: In addition it has been shown in research to improve body composition.
To wrap it up it appears that in a research setting that clenbuterol markedly increases fat loss, decreases muscle wasting, and provides to some degree an anabolic response. An interesting substance for our research to be sure.
REFS:
*Hallows KR, Alzamora R, Li H, et al. (April 2009). Am. J. Physiol., Cell Physiol. 296 (4):C672–81. PMID 19211918.
*The effect of clenbuterol on body composition in spontaneously eating tumour-bearing mice.
Hyltander A, Svaninger G, Lundholm K. Biosci Rep. 1993 Dec;13(6):325-31. PMID: 8204802
*Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation Johnson M. J Allergy Clin Immunol. 2006 Jan;117(1):18-24; quiz 25. Review. PMID: 16387578
*Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats. Ryall JG, Plant DR,Gregorevic P, Sillence MN, Lynch GS. J Physiol. 2004 Feb 15;555(Pt 1):175-88. Epub 2003 Nov 14. PMID: 14617677
*Effect of a selective beta 2-adrenergic agonist (clenbuterol) on energy balance and body composition in normal and protein deficient rats. Rothwell NJ, Stock MJ. Biosci Rep. 1987 Dec;7(12):933-40. PMID:3453750
So let’s put that all together. Clenbuterol bonds to the beta 2 receptor and triggers a response. So what is that response? Well beta 2 receptor activation results in the production of cyclic adenosine monophosphate (cAMP). CAMP then results in an activation of protein kinease A (PKA). PKA has several functions including sugar metabolism, lipid metabolism, and glycogen regulation. Also beta 2 activation results in a decrease in intracellular calcium and an increase in potassium flow (Perhaps why in our research we may observe cramping?)
So all that sounds great and we could go very in depth with how these reactions occur to an even more minute level but let’s focus on what this beta 2 receptor activation ultimately does. Ultimately there are several effects that occur from this beta 2 receptor activation:
1: Blood vessel dilation (relaxation of smooth muscle)
2: Bronchodilation
3: Increase in metabolic activity
4: Increase in core temperature
5: Increase in basal metabolic rate
These effects provide some interesting results in our research.
1: It has been found that clenbuterol has the unique ability to preserve muscle in a state of caloric deficit while increasing the metabolism of fat.
2: It was also observed that clenbuterol has the ability to reverse muscle wasting.
3: In addition it has been shown in research to improve body composition.
To wrap it up it appears that in a research setting that clenbuterol markedly increases fat loss, decreases muscle wasting, and provides to some degree an anabolic response. An interesting substance for our research to be sure.
REFS:
*Hallows KR, Alzamora R, Li H, et al. (April 2009). Am. J. Physiol., Cell Physiol. 296 (4):C672–81. PMID 19211918.
*The effect of clenbuterol on body composition in spontaneously eating tumour-bearing mice.
Hyltander A, Svaninger G, Lundholm K. Biosci Rep. 1993 Dec;13(6):325-31. PMID: 8204802
*Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation Johnson M. J Allergy Clin Immunol. 2006 Jan;117(1):18-24; quiz 25. Review. PMID: 16387578
*Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats. Ryall JG, Plant DR,Gregorevic P, Sillence MN, Lynch GS. J Physiol. 2004 Feb 15;555(Pt 1):175-88. Epub 2003 Nov 14. PMID: 14617677
*Effect of a selective beta 2-adrenergic agonist (clenbuterol) on energy balance and body composition in normal and protein deficient rats. Rothwell NJ, Stock MJ. Biosci Rep. 1987 Dec;7(12):933-40. PMID:3453750
