Dnp and t3
- Thread starter stano
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DNP Guru
DNP doesn't shut down the thyroid. This is a common myth. AAS and DNP have a similar effect on thyroid, through a similar mechanism of action. While androgens reduce the concentration of thyroid binding globulin (TBG), DNP occupies thyroid binding proteins, which has the same result... less protein to bind to thyroid. This may initially result in higher serum levels and accelerated clearance, but after a short term alteration in thyroid function a new steady state is soon reached in which thyroid function is normal, despite potentially reduced serum levels of total T4 and total T3. As one paper on DNP explained, "this action could lower the total hormone concentration in serum but should have no persistent effect on thyroid function". This means that even though the level of thyroid hormones in the blood can potentially be lower than normal, thyroid function will still be normal. What I've seen happen most of the time, however, is that thyroid levels hardly change.
There's a case study that's often posted as evidence for thyroid dysfunction from DNP, but I'm of the opinion that the bodybuilders in question had low thyroid levels not because of the DNP, but because they were taking T3 during their cycle. Exogenous T3 definitely will suppress endogenous production. I had a Norwegian translate the paper and it was unclear why they had low thyroid levels. They didn't test for reverse thyroid when they could have, which would have made the cause clearer.
I also have a friend who's a doctor of internal medicine who ran 600mg/day of crystal DNP for 3-4 months (went from 320 lbs down to the mid 200's). He gave himself frequent blood tests and said his thyroid didn't budge. I've heard feedback from several others who did blood work showing the same thing.
I'm just not convinced that DNP results in any thyroid dysfunction. You definitely do NOT need to take thyroid along with DNP. Considering how notoriously catabolic thyroid is, I'd recommend leaving it out of your dieting plan.
There's a case study that's often posted as evidence for thyroid dysfunction from DNP, but I'm of the opinion that the bodybuilders in question had low thyroid levels not because of the DNP, but because they were taking T3 during their cycle. Exogenous T3 definitely will suppress endogenous production. I had a Norwegian translate the paper and it was unclear why they had low thyroid levels. They didn't test for reverse thyroid when they could have, which would have made the cause clearer.
I also have a friend who's a doctor of internal medicine who ran 600mg/day of crystal DNP for 3-4 months (went from 320 lbs down to the mid 200's). He gave himself frequent blood tests and said his thyroid didn't budge. I've heard feedback from several others who did blood work showing the same thing.
I'm just not convinced that DNP results in any thyroid dysfunction. You definitely do NOT need to take thyroid along with DNP. Considering how notoriously catabolic thyroid is, I'd recommend leaving it out of your dieting plan.
