Estradiol levels and Amiradex

[Ll5073]

Quick question
Started TRT in April- was doing 200 mg test cyp weekly, after 6-7 weeks in my nipples started getting tender. I went to the dr and had blood work done- test level was 997 and estradiol was 67- I was prescribed amiradex 1 mg twice a week and advised to lower my test to 150 mg a week. Follow up blood work 14 weeks into trt test levels was 907 test and 12 estradiol. Doc advised to quit amiradex completely but after voicing my concerns about the initial high number we agreed on 0.5 mg twice a week. Do you guys think this will be ok to obtain a 20-30 estradiol level? Just wondering b/c don't have my follow up blood work until next year and thinking about doing a private md test or is that just overkill?

 

[3J]

yea.. that should work out.. but i think you should go with .25mg twice a week.. retest.. and see if you need to get to .5

 

[Alpin]

How many days from shot is the 997 TT ?
0.5 mg is a lot. I would go 0.25 E3D or EOD if estradiol continues to be a problem.

 

[Ll5073]

both the tt was 2 days after shot- 997 with 200 mg and 907 with 150 mg- I do shots on Monday and both tests on Wednesdays- next test I will do on Monday am before shot- I switched doctors between tests so he made sure to tell me we need a trough level on the next test

 

[Ll5073]

i just thought that if 2 mg a week put it at 12, maybe 1 mg a week would put it in range- How long after reducing dose should i wait to get estradiol levels rechecked?

 

[STAUNCHED427]

The only way to know is via blood tests. Accurately know anyway.

If your doing 75mg shots 2x weekly, go with .25mg Adex with each shot and take it from there with bloods. Get your blood tests done on the morning of when your meant to do your shot, that will give you a trough reading.

 

[Ll5073]

gotcha- not dividing shots though, just one shot a week

 

[STAUNCHED427]

I wouldn't go with once per week shots... Blood levels will swing a lot... The more frequent the better. This ain't broscience, it's real life experiences and everyone will agree on that.

 

[Ll5073]

I will do that then- That's why I joined this group- to learn. I have found that the Dr has a limited amount of hands on knowledge and I appreciate the input. Maybe a monday/Thursday combo?

 

[STAUNCHED427]

Majority of doctors have no clue what they are doing with TRT. A lot won't prescribe an AI and monitor estradiol, injection frequency too far apart etc. In saying that, there are some doctors who are up to date with TRT.

When talking to your doc about it, don't push it, just suggest things, for example. "Hey doc, I was doing a little bit of research online and came across a lot of people having success by splitting their dose up from 1x weekly to 2x weekly, they find they are able to take less adex because it controls their estrogen by causing less spikes in hormone levels, what are your thoughts on it?" Reason being is a lot of docs will take it as your trying to tell them how it is, which is true, but so is what your saying in this case.

I personally do it Sunday AM/Wednesday PM so roughly ~82 hours between each shot. I do 100mg Test E but may be switching to Exemestane (Aromasin) as my AI over Anastrozol (aka Adex/Arimidex) again taking it 2x weekly with each shot.

And on the side, before anyone pulls out the Stane needs to be dosed ED bullshit, you must remember that yes the half life is very short, BUT, aromasin is a suicidal inhibitor unlike letro/adex, so whilst yes it may be out of your system quickly you must remember it permanently binds and deactivates aromatase so regardless of half-life the aromatase has to be produced before levels climb up again. A lot of people don't seem to realise this. It is not a direct receptor mediated drug. There is a study that proved 25mg Aromasin lowers estrogen and starts to climb again by day 3, I'll try find it. And if you think Stane can't crash your e2, I am living proof amongst others THAT IT CAN.

 

[Alpin]

Majority of doctors have no clue what they are doing with TRT. A lot won't prescribe an AI and monitor estradiol, injection frequency too far apart etc. In saying that, there are some doctors who are up to date with TRT.

When talking to your doc about it, don't push it, just suggest things, for example. "Hey doc, I was doing a little bit of research online and came across a lot of people having success by splitting their dose up from 1x weekly to 2x weekly, they find they are able to take less adex because it controls their estrogen by causing less spikes in hormone levels, what are your thoughts on it?" Reason being is a lot of docs will take it as your trying to tell them how it is, which is true, but so is what your saying in this case.

I personally do it Sunday AM/Wednesday PM so roughly ~82 hours between each shot. I do 100mg Test E but may be switching to Exemestane (Aromasin) as my AI over Anastrozol (aka Adex/Arimidex) again taking it 2x weekly with each shot.

And on the side, before anyone pulls out the Stane needs to be dosed ED bullshit, you must remember that yes the half life is very short, BUT, aromasin is a suicidal inhibitor unlike letro/adex, so whilst yes it may be out of your system quickly you must remember it permanently binds and deactivates aromatase so regardless of half-life the aromatase has to be produced before levels climb up again. A lot of people don't seem to realise this. It is not a direct receptor mediated drug. There is a study that proved 25mg Aromasin lowers estrogen and starts to climb again by day 3, I'll try find it. And if you think Stane can't crash your e2, I am living proof amongst others THAT IT CAN.

After how many hours do you fell the Test kicking in?
You take the adex at same time as shot ?
Maybe it's ok to take the adex 4 hours or so after shot ???
To keep from crashing estradiol. Because on that third day from last shot your estradiol would be lower.

 

[STAUNCHED427]

I don't really feel the Test kick in... I know others do feel something, but this is the whole point of 2x weekly injects, to avoid an e2 and test rollercoast.

Taking the adex with the shot, it gets absorbed so an hour, then it inactivates aromatase, thereby estrogen slowly starts lowering but the injection is already starting to climb. My theory anyway, it does work for me. Although I have a mate who said he felt better taking the adex 24 hours post shot whilst on a 250mg cruise. Trial and error plays a big role in dialling in TRT.

 

[Alpin]

I don't really feel the Test kick in... I know others do feel something, but this is the whole point of 2x weekly injects, to avoid an e2 and test rollercoast.

Taking the adex with the shot, it gets absorbed so an hour, then it inactivates aromatase, thereby estrogen slowly starts lowering but the injection is already starting to climb. My theory anyway, it does work for me. Although I have a mate who said he felt better taking the adex 24 hours post shot whilst on a 250mg cruise. Trial and error plays a big role in dialling in TRT.

Was he on a E7D cruise of 250 mg when he took the adex day before?

 

[STAUNCHED427]

No this was injecting 2x weekly.

 

[bigben66]

I'm on 1000mg/4ml every 4 weeks of Test Undecanoate, which obviously equates to 250mg/week...

I have found that 0.5mg Adex E5D works for me... I tried to go as low as 0.25mg but my pill splitter was just turning the tablets into powder... so I just spread the days out a bit more and stuck to half a tablet.

I do wonder why UGL's never think to make tablets in smaller dosages - after all they supply BB'ers for this sole purpose, whereas the Pharmaceutical 1mg tablet is fine for it's intended purpose...

 

[bigben66]

Just reading through this thread... and considering docs in the US are massively more educated on TRT than the docs here in the UK...

I am amazed that more US docs aren't trialling Testosterone Undecanoate - I used to pin Sustanon 2 x weekly, now I am on Nebido (brand name for undecanoate) I only have to pin every 4 weeks. I know some guys in the UK are on 6 or even 8 weekly injections...

It certainly seems the way forward for me, and I know Austinite is a huge fan of this delivery protocol.

 

[TRTnooby]

Nebido is not approved here unfortunately.

 

[Megatron28]

Nebido is not approved here unfortunately.

Actually, I think it was recently approved in the US. But it is insanely expensive.

 

[bigben66]

I heard it was expensive, something like 5 x more expensive than the Sustanon... which is why I'm puzzled that they've made the transition to it...

 

[Ll5073]

The Bayer Nebido website doesn't show its available in the US yet