Daniel_IMT_Staff
New member
Estrogen is typically looked down upon and seen as a female sex hormone, it is very important for men as well and needs to be balanced accordingly. Estrogen in men is mainly converted via androstenedione or testosterone via an enzyme called aromatase. There are three different types of estrogen but the ones we concern ourselves with is estradiol. The main concerns in regards to estrogen pertain to gynecomastia, water retention, lipid profile, blood pressure, hematocrit, libido, hGH & IGF-1, endogenous testosterone production, neurotransmitters(emotions) and the list can go on.
Lipids
Estrogen will have an inhibitory effect on the oxidation of low density lipoprotein (LDL or bad cholesterol.) So what does that mean? The more estrogen the better it is for my lipids? No not necessarily, but bringing your estrogen too low for a long period of time will have a negative effect on your lipid profile. Having a little extra estrogen is much better than having too little. When we talk about lipids it is important to understand what were are really talking about. It is mainly focused on cardio vascular disease which rates high on the national scale of health problems. It is one of the most preventable diseases which are ignored for far too long. If you pose the question of why obese men with high estrogen often suffer from cardiovascular disease it is because of hypertension, diabetes (insulin levels) and an excess of totally lipids circulating. As we will be discussing later, when using an aromatase inhibitor (AI) to decrease estrogen it is common that it is the Aromatase inhibitor (AI) is blamed for the bad lipid panel when in reality it is a result too low estrogen.
Growth Hormone
Another key role that estrogen plays which is often overlooked is precious hGH production and the consequential IGF-1 increase. Prolactin plays a large role in the regulation of hGH also. Anything that can be done to increase endogenous hGH production should never be overlooked and having too low estrogen will consequentially strangle hGH production. Many other SERMs that attach to specific estrogen receptors in the brain do not express the same effects that estrogen does which can also decrease hGH, tamoxifen is known for this.
Water Retention
Estrogen will effect subcutaneous water retention or bloat. Estradiol will regulate arginine vasopressin which is a hormone which increases water retention and constricts blood vessels. Too much bloat is bad and will result in higher blood pressure as well due to the constricted blood vessels. Labs are always going to be the best indication on what your estrogen is. What you can do as well to control for if your estrogen levels are going up or down is by using a body fat caliper. The subcutaneous water retention will show up as ***8220;body fat***8221; on a caliper and instead of getting weekly labs done for your estrogen using a caliper can be a good indication of its rise and fall. This should never be used as a precise measurement, but I have found it to be useful when my estrogen levels have been way off and tracking its progression whether it is going too low or still rising/no change.
Obesity and cardiovascular disease
Obesity and cardiovascular disease
Antioxidant Protection of LDL by Physiological Concentrations of 17***946;-Estradiol
Antioxidant Protection of LDL by Physiological Concentrations of 17?-Estradiol
Estrogen Regulation of Growth Hormone Action
Estrogen Regulation of Growth Hormone Action
Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone
Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone
Effects of Sex and Age on the 24-Hour Profile of Growth Hormone Secretion in Man: Importance of Endogenous Estradiol Concentrations
Effects of Sex and Age on the 24-Hour Profile of Growth Hormone Secretion in Man: Importance of Endogenous Estradiol Concentrations
Estrogen receptor alpha is involved in the estrogenic regulation of arginine vasopressin immunoreactivity in the supraoptic and paraventricular nuclei of ovariectomized rats.
Estrogen receptor alpha is involved in the est... [Neurosci Lett. 2010] - PubMed - NCBI
Effect of ovarian sex steroids on osmoregulation and vasopressin secretion in the rat
Effect of ovarian sex steroids on osmoregulation and vasopressin secretion in the rat
Lipids
Estrogen will have an inhibitory effect on the oxidation of low density lipoprotein (LDL or bad cholesterol.) So what does that mean? The more estrogen the better it is for my lipids? No not necessarily, but bringing your estrogen too low for a long period of time will have a negative effect on your lipid profile. Having a little extra estrogen is much better than having too little. When we talk about lipids it is important to understand what were are really talking about. It is mainly focused on cardio vascular disease which rates high on the national scale of health problems. It is one of the most preventable diseases which are ignored for far too long. If you pose the question of why obese men with high estrogen often suffer from cardiovascular disease it is because of hypertension, diabetes (insulin levels) and an excess of totally lipids circulating. As we will be discussing later, when using an aromatase inhibitor (AI) to decrease estrogen it is common that it is the Aromatase inhibitor (AI) is blamed for the bad lipid panel when in reality it is a result too low estrogen.
Growth Hormone
Another key role that estrogen plays which is often overlooked is precious hGH production and the consequential IGF-1 increase. Prolactin plays a large role in the regulation of hGH also. Anything that can be done to increase endogenous hGH production should never be overlooked and having too low estrogen will consequentially strangle hGH production. Many other SERMs that attach to specific estrogen receptors in the brain do not express the same effects that estrogen does which can also decrease hGH, tamoxifen is known for this.
Water Retention
Estrogen will effect subcutaneous water retention or bloat. Estradiol will regulate arginine vasopressin which is a hormone which increases water retention and constricts blood vessels. Too much bloat is bad and will result in higher blood pressure as well due to the constricted blood vessels. Labs are always going to be the best indication on what your estrogen is. What you can do as well to control for if your estrogen levels are going up or down is by using a body fat caliper. The subcutaneous water retention will show up as ***8220;body fat***8221; on a caliper and instead of getting weekly labs done for your estrogen using a caliper can be a good indication of its rise and fall. This should never be used as a precise measurement, but I have found it to be useful when my estrogen levels have been way off and tracking its progression whether it is going too low or still rising/no change.
Obesity and cardiovascular disease
Obesity and cardiovascular disease
Antioxidant Protection of LDL by Physiological Concentrations of 17***946;-Estradiol
Antioxidant Protection of LDL by Physiological Concentrations of 17?-Estradiol
Estrogen Regulation of Growth Hormone Action
Estrogen Regulation of Growth Hormone Action
Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone
Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone
Effects of Sex and Age on the 24-Hour Profile of Growth Hormone Secretion in Man: Importance of Endogenous Estradiol Concentrations
Effects of Sex and Age on the 24-Hour Profile of Growth Hormone Secretion in Man: Importance of Endogenous Estradiol Concentrations
Estrogen receptor alpha is involved in the estrogenic regulation of arginine vasopressin immunoreactivity in the supraoptic and paraventricular nuclei of ovariectomized rats.
Estrogen receptor alpha is involved in the est... [Neurosci Lett. 2010] - PubMed - NCBI
Effect of ovarian sex steroids on osmoregulation and vasopressin secretion in the rat
Effect of ovarian sex steroids on osmoregulation and vasopressin secretion in the rat
