GOOD reason to use T3 in your bulkers....

[Drveejay11]

http://cs.portlandpress.com/cs/104/cs1040007.htm

Key words: glucose utilization, hyperinsulinaemic clamp, hyperthyroidism, hypothyroidism, insulin responsiveness.

Abbreviations: T3, 3,3´,5-tri-iodothyronine; T4, thyroxine.

Correspondence: Dr J. Grizard (e-mail grizard@clermont.inra.fr).

We have examined insulin action on glucose metabolism in six hypothyroid patients before and after regular thyroid hormone treatment, and in six healthy volunteers before and after transient induction of moderate hyperthyroidism. Insulin was infused under euglycaemic and eukalaemic clamps. An appropriate amino acid infusion was used to blunt insulin-induced decreases in amino acid levels. Glucose kinetics were assessed using a primed continuous infusion of [6,6-2H2]glucose. The results showed that basal plasma insulin and glucose levels (i.e. before infusion) were similar in each case. Despite similar insulin infusion rates, the plateau value of insulin was lower after thyroid treatment in both hypothyroid patients and healthy volunteers. The rate of exogenous glucose needed to maintain plasma glucose at a steady-state level was increased by thyroid hormone in hypothyroid patients (P<0.05), but not in healthy volunteers. Thyroid treatment resulted in a significant increase in basal glucose disposal in both groups (P<0.05). Insulin, in conjunction with glucose and amino acids, significantly stimulated glucose disposal (P<0.05) under all conditions. The incremental increase in glucose disposal after infusion tended to be higher following thyroid hormone treatment, but this was not statistically significant. However, the ratio of the incremental increase in glucose disposal to the increase in plasma insulin was significantly improved after thyroid hormone treatment in hypothyroid patients (P<0.05). It was also increased in healthy volunteers, but not significantly. We conclude that thyroid hormones improve the ability of insulin to stimulate glucose disposal related to insulinaemia. This phenomenon may be highly sensitive, because it was only apparent at low thyroid hormone levels.


Received 11 June 2002; accepted 10 October 2002


The Biochemical Society and the Medical Research Society © 2003


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[argent]

Good read. Fairly jargon-ridden. but still a good read. I have a question though. T-3 added for bulking seems to be a very positive thing. Most everyone I've spoke with says 12.5 mcg is a good dose for bulking use. Now for what duration of use would 12.5 mcg become suppresive?

 

[Drveejay11]

I think anywhere up to 25 mcg is relatively safe with respect to recovery for periods up to 10 weeks!!! I have yet to read any studies that illustrate Thyroid down regulation at suck low doses AND I have never read ONE abstract relaying that your Thyroid has difficulties recovering whatsoever at low doses! However....I'd rather err on the side of caution and ASSUME that after 8-10 weeks....a break would be indicated!

 

[Mudge]

How long should breaks be? I'm sure this is somewhat individual but what is our interweb rule of thumb, time on = time off or do we go by the claims that we "all bounce back after a 'few' weeks"?

 

[Drveejay11]

You are ALWAYS safer taking MORE time OFF

Even with T3.....time on should equal time off (just to be safe)

 

[argent]

I've read that the HPTA becomes suppressed at around 12-14 days during a cycle. Is there any set duration for t3?

 

[Mudge]

I'd also like to know, who takes it all at once vs two doses?

 

[tyhigs]

I have a different interpretation of that study than the rest of you guys. I read that it is hardly effective for people with normal thyroid levels, and it is only effective for those with hypothyroidism.

" However, the ratio of the incremental increase in glucose disposal to the increase in plasma insulin was significantly improved after thyroid hormone treatment in hypothyroid patients (P<0.05). It was also increased in healthy volunteers, but not significantly. We conclude that thyroid hormones improve the ability of insulin to stimulate glucose disposal related to insulinaemia. This phenomenon may be highly sensitive, because it was only apparent at low thyroid hormone levels.
"

 

[mr.zone]

I have a different interpretation of that study than the rest of you guys. I read that it is hardly effective for people with normal thyroid levels, and it is only effective for those with hypothyroidism.

" However, the ratio of the incremental increase in glucose disposal to the increase in plasma insulin was significantly improved after thyroid hormone treatment in hypothyroid patients (P<0.05). It was also increased in healthy volunteers, but not significantly. We conclude that thyroid hormones improve the ability of insulin to stimulate glucose disposal related to insulinaemia. This phenomenon may be highly sensitive, because it was only apparent at low thyroid hormone levels.
"

Thats because the study dosen't point out that when taking high levels of exogenous AS, it can put you in a hypothyroid state. I think that DRveejay was assumeing you already new that.