hgp.gob.ec/index.html/uptodate/contents/UTD.htm?9/1/9240?source=see_link
"Reduction — Aldosterone, like cortisol, is reduced predominantly by a hepatic delta-4, 3-ketosteroid reductase, and a 3 alpha-hydroxysteroid dehydrogenase ( figure 1 ). The cytosolic delta-4-reductase also has 5 beta-hydroxysteroid reductase activity, so that the major ********* product is 3 alpha, 5-beta-tetrahydroaldosterone. This metabolite, in the form of tetrahydroaldosterone glucuronide, accounts for 35 to 40 percent of the aldosterone metabolites in urine [ 64 ]. A 21-deoxy form of tetrahydroaldosterone is further reduced to the 20-alpha-hydroxy form [ 65 ]. The 20-alpha-hydroxyl group can condense with the hydroxyl of the C18 hemiacetal to form an aldosterone metabolite with bicyclic acetal rings [ 66 ]."
Seems to me that aldactone could be used to prevent androgenic side effects in areas that aren't high in 3 alpha-hydroxysteroid dehydrogenase. Just like DHT, aldactone does not survive long in muscle tissue. So gentleman, have your cake and eat it too.
"Reduction — Aldosterone, like cortisol, is reduced predominantly by a hepatic delta-4, 3-ketosteroid reductase, and a 3 alpha-hydroxysteroid dehydrogenase ( figure 1 ). The cytosolic delta-4-reductase also has 5 beta-hydroxysteroid reductase activity, so that the major ********* product is 3 alpha, 5-beta-tetrahydroaldosterone. This metabolite, in the form of tetrahydroaldosterone glucuronide, accounts for 35 to 40 percent of the aldosterone metabolites in urine [ 64 ]. A 21-deoxy form of tetrahydroaldosterone is further reduced to the 20-alpha-hydroxy form [ 65 ]. The 20-alpha-hydroxyl group can condense with the hydroxyl of the C18 hemiacetal to form an aldosterone metabolite with bicyclic acetal rings [ 66 ]."
Seems to me that aldactone could be used to prevent androgenic side effects in areas that aren't high in 3 alpha-hydroxysteroid dehydrogenase. Just like DHT, aldactone does not survive long in muscle tissue. So gentleman, have your cake and eat it too.
