From my research (reading members post) and advice from Ology members, start out the Prami at .25 ED and work up from there as needed.
I'm up to .50 ED but I split it up - .25 AM / .25 PM
Made me sick as hell when I first started taking it. Now it's no problem but it took a few weeks to get there...
Most I've ever taken is 1ml ED and no more issues...
I'm on Hormone Replacement Therapy (HRT) so I never take Letro, sorry!