I went to the popular "mens clinic" in honolulu after hearing their radio ads. My testosterone was 380 at the time and they were quick to sign me up with all "benefits" I'd receive. I bought in. The first month and a half was great; my second injection of testosterone, mixed with grape seed oil (so it absorbs slower into the muscle) I noticed greater mental clarity. My stamina improved as well in workouts and recovery time was quicker. At the month and a half mark, I started having transient (random/traveling) joint pain in my wrists and shoulders. Polyarthritic symptoms; osteo and rheumatoid. I would literally wake in the middle of the night screaming in pain, wrist, shoulder or fingers inflamed. The doctor denied any knowledge of a relationship with the testosterone (side effects). After a couple visits to different doctors, one finally, hooked me up with an endocrinologist. She told me 3% of men have these symptoms. She said, "It is the medicine (testosterone replacement therapy) that is causing it. If you continue to use it, you will continue with these effects, your testicles will shrink and atrophy-to the point if you stop the therapy they won't grow back. Your penis will shrink also, and your liver will ultimately pay the price." I've been off the therapy for about 2 months and the pain has shifted to my knees, ankles and the lateral aspects of my feet. The pain isn't as sever and it is diminishing with time. I saw the endocrinologist the other day and she said I still have the residual effects and it should be gone within the next 3 months. Oh yeah, my PSA went from 3.6 to 4.6 during the therapy, but the doctor at the mens clinic said "PSA really isn't a good marker," so with his encouragement, I stayed with the program. I had ED during this little adventure too. I read an article which said if your testosterone is below 300 you might consider it. My advice-investigate the pro's and con's. The boys at the clinic said everything positive to keep my $$$$, and even when I told them what the endocrinologist said, they still tried to keep me on the testosterone. Get info from the endocrinologist and other folks who aren't in it for the buck.