Im not completely positive but I think it would be like any other drug. Meaning, that you would have to take it for a long period of time for your body to build up a tolerance to it. I think you would be perfectly ok going from Letro to Arim or Aromasin ( I have done it a few times with different Ai's)
Here is info I found as well:
"molecular oxygen to generate hydroxy groups) they turn insoluble substances into soluble substances.
The smooth E.R. rapidly proliferates to get rid of the toxic substance and so the next time the drug is given, there is more smooth E.R. so it can get rid of the substance more quickly thus more is needed to create the same effect.
The main concern with this and long term drug use is that via the hydroxylation reactions, carcinogenic (cancer causing) byproducts can be formed...
That's something from very old literature, and, as far as I know, only applies to alcohol effects on liver cells. The liver increases production of alcohol dehydrogenase (a mechanism involving the smooth ER), which helps to metabolize the alcohol faster. But that's not truly tolerance as much as more rapid clearance to keep blood concentrations of ethanol lower.
Drug tolerance, where higher doses reaching cells have less effect on the cells, as occurs in the process of addiction, is related to the availability of the receptors for that drug. As has been described above by others, part of the mechanism for tolerance is at the level of receptor availability, such as via a change in the rate of receptor internalization, recycling, or de novo synthesis. There may also be a change in how the signal transduction pathways respond following receptor binding. So, it's certainly not a simple process. Understanding this is not only important for treatment of addiction, but also for preventing tolerance/addiction in patients being treated with drugs for reasons such as pain management."
