It all comes down to you.
As far as a true Aromatase inhibitor (AI) is concerned, No, Arimedex HD that you can buy on the shelf is not the same.
With that said, I've used it every time I've done a cycle, I take one every morning, and start it at the beginning of my cycle. There are only 28 caps per bottle, so out of 2 bottles you get 8 weeks worth,..from there I will run the last 4 weeks with nothing, then when I start my post cycle therapy (pct) I feel like I'm in a good spot.
With that said, I'm not gyno prone, and to date have yet to see any estro-related issues.
Definitely have the real-deal as far as your post cycle therapy (pct) goes.
Bottom line, I'm really happy with Arimedex HD, especially since it's an OTC product.