Plateletpheresis elevating bilirubin?

Mprtz

New member
It might be a long shot that I get a definitive answer for this, but here goes:

I donate platelets to help manage my hematocrit on TRT (see other threads on this). This typically lowers my HCT 2 or 3 percent.
I do the platelet donation between whole blood donations as needed.

Late last year, I went in for platelets donation. I think the in-office HCT test was 47 or so.

10 days later I did a private blood test. HCT was surprisingly high at 51, and bilirubin was somewhat elevated (1.5 0.0-1.2)

16 days later I went in for a whole blood donation, the in-office HCT test was 49.

A few weeks later, another blood test showed it down to 45.

Did another platelet donation yesterday, and today noticed that my urine was more yellow than usual.

Ok, bear with me - this is what I think may be happening:

Bilirubin is the yellow breakdown of dead blood cells. Since plateletpheresis attempts to return almost all red blood cells to the body, the observed drop in HCT has to mean that some red blood cells are being destroyed (hemolysis).
This could explain the elevated bilirubin levels as the liver works to clear the blood of dead red blood cells, and also that the HCT drop due to plateletpheresis doesn't seem to be instantaneous, but seems to be a gradual process.

Is there a hematologist in the house?
 
If your worried about Bilirubin being elevated go to the tanning salon. New born babies have elevated bilirubin all the time they just put the baby under a sun lamp.
 
If your worried about Bilirubin being elevated go to the tanning salon. New born babies have elevated bilirubin all the time they just put the baby under a sun lamp.

I've read about phototherapy for infants, but I don't think it is effective for adults. I'm not really worried about the slightly elevated levels (though I will be watching and re-test), but would like to understand the cause. I ain't a heavy drinker.
 
I think you are on to the right path. I would personally stop donating for a while, and retest...if it is normal, then your theory would seem to be right. However, it it's still abnormal...you might have something to worry about.
 
I think you are on to the right path. I would personally stop donating for a while, and retest...if it is normal, then your theory would seem to be right. However, it it's still abnormal...you might have something to worry about.

Thanks, I did some more searching and read about oxidative stress in apheresis and hemolysis induced hyperbilirubinemia and it still makes a lot of sense to me but nothing putting it all together.

I'm not really too concerned about the slightly elevated bilirubin - it's nowhere near jaundice levels. I just would like to understand where it comes from since my other liver values (ALT, AST) are fine.

I agree I need to wait and re-test. I may even test before and after to test my theory...
 
I was kind of hoping halfwit - lord of platelet apheresis, who has fix-a-flat for blood and can fill a bag with platelets in mere minutes - would comment on this thread...
 
I forgot to mention that the foam of your urine is what you want to look at....if it's yellow, it indicates a high likelihood for bilirubin.
 
Last edited:
Back
Top