Proviron & Tren (benefits)

.Vision.

Euro-Pharmacies
So, the discussion has came about many times over in regards to depression,aggression and/or anxiety,or other sides when on cycle/blast when utilizing Trenbolone, or at times other compounds!

Let's discuses Tren and one compound that can help assist with side effects that can be unbearable for most,especially anxiety..So lets talk about this shall we?



Please allow me to illustrate one of shrouded and seldom discussed Drugs in the whole anabolic circuit, with one of the most underrated/pronounced effects ever, that somehow has failed to be discussed upon the masses...

"Proviron" Mesterolone


Most of you that have ever took the breakfast of champions "Methandrostenolone", That's right, I'm talking about Dbol. What's the most apparent and conspicuous effects that takes place while taking Dbol? If you were about to say the "sense of well-being" than your correct. One of the most profound and desirable effects that we can have during a cycle..Now, how about after a cycle? Or for longer duration's? But we all know that many of us practice moderation with harsh orals,or I would hope,But, have no concerns with elevated toxicity here!

One of the greatest characteristics about Proviron that has been shrouded and seldomly discussed is it's "Antidepressant" properties. With this being said, when it was first developed it was widely utilized in treatments for Bi-polar,OCD and Anxiety. As we know that depression is basically a chemical imbalance that comes about through the "Signaling" issues between receptors. Proviron improves the quality of the "channels" that the cells use to communicate and interact. Thus, a similar effect with Dbol where it drastically improves the sense of well being in users. Much like Antidepressants, SSRI (Selective serotonin re-uptake inhibitor, and/or,SNRI (Serotonin-nor-epinephrinere-uptake inhibitor)

What I'm about to share is a double blind study that clearly shows undoubtedly astonishing results in the patients! An other great reason to consider this compound.
Why proviron is underestimated, the world may never know

Tren is the compound that's well known for having a love hate relationship with most users. Most will deem it a necessary evil. But, in fact it doesn't have to be classified as evil after all.

Allow me to intro some clinical studies that have been conducted with a compound most commonly known as Proviron-trade name (Mesterolone).This agent posses some amazing characteristics with Antidepressant properties, as well Anti-anxiety.
It works by also metabolizing and being recognized through the endocrine as (other) a neurosteroid,effectively functioning as a so-called proneurosteroid (testosterone is also recognized as one).. These steroids synthesized in the brain (Proviron especially) and have effects on brain function,In addition to their actions on neuronal membrane receptors,improving the quality of the channels that cells use to communicate and interact.


Proviron/or Masteron and Tren (Masteron can be utilized due to it's targeting similarities)
Proviron(mesterolone) will exert inhibitory actions on neurotransmission, acting as potent positive allosteric modulator of the GABA receptor (This is crucial concerning Tren-Insomnia as healthly function levels ofGABA will produce a stable sleep state/environment for rest) and possess, in no particular order, antidepressant,stress-reducing, feeling warm/fuzzy/rewarding,pro-social, anti-aggressive(huge consider tren sides),pro-sexual,sedative/pro-sleep,cognitive-memory improvement..The list goes on!

(Where does this apply with Tren? It can aid all the way around with individuals how are sensitive or not.From the social aspect,overwhelming sense of anxiety,lack of sleep,basically everything stated above that may apply with the usage of tren and the onset of its unwanted side)

In addition to this information, an individual can also utilized masteron (Drostanolonein) in conjunction with Proviron, running both concurrent may yield a great synergenic effect,each compound will compliment one an other.

Further more Proviron is a DHT derivative. DHT compounds assist with hardening of the physique, lack of water retention,increased sex drive..Hardening of the physique and lack of water retention go hand in hand. Proviron assists with this, The body recognizes proviron as a DHT,This causes a direct hardening affect on the muscle tissue (Like mast posses,but mast is much more stronger IMO) The increase in hardness comes from a reduction in free estrogen levels, because proviron has the ability to 'latch-on' to the estrogen binding enzymes,It competes so to speak for its position,it does this aggressively, thus decreasing water retention. Also the the lack of aromatization and the fact that the drug is prototypical androgen, causes a significant shift in the body’s estrogen/testosteroneratio.As proviron's atomic structure it is incapable of forming estrogen. It also has properties with AR's.. Increasing the AR expression, proviron/DHT uptake to further increase AR expression, repeating this process over and over ...
This allows other AAS compounds to appear to be amplified with there effects,assisting the compounds - (What does this mean?) It can be a master key so to speak, having multiple functions - It binds aggressively to the AR's and SHBG, thus it can/may increase the activity of other STEROIDS in the system) - This is an added bonus!

Learn more about Proviron here - PSL


Functions concerning the neurotransmitter/receptor and how it works:Below is a image illustrating the neurotransmitter/receptor and how it functions, also I will include some real actual studies conducted with proven results expressing the benefits of this compound (proviron)
Keep in mind that these doses may seem extreme,its been proven time and time again that such significant dosages are not needed to yield the effect. Merely a daily intake of 50-100 will suffice for almost anyone!

main-qimg-c1b39c3a7cbe266c827cf21bc88ce7e8


Citation
Database: PsycINFO
[ Journal Article ]
A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men.
Vogel, William; Klaiber, Edward L.; Broverman, Donald M.
Journal of Clinical Psychiatry, Vol 46(1), Jan 1985, 6-8.

Abstract



26 depressed male outpatients were randomly assigned to 14 wks of treatment with either mesterolone or amitriptyline in a double-blind parallel treatment design. Ss completed the Hamilton Rating Scale for Depression and a symptom checklist each week. Findings reveal that the drugs were equally effective in reducing depressive symptoms. Mesterolone produced significantly fewer adverse side effects than amitriptyline and did not produce hypomania or tachycardia, recognized side effects of amitriptyline. (10 ref) (PsycINFO Database Record (c) 2013 APA, all rights reserved)




Methods Find Exp Clin Pharmacol. 1984 Jun;6(6):331-7.
The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study).
Itil TM, Michael ST, Shapiro DM, Itil KZ.

Abstract

Based on computer EEG (CEEG) profiles, in high doses, antidepressant properties of mesterolone, a synthetic androgen, were predicted. In a double-blind placebo controlled study, the clinical effects of 300-450 mg daily mesterolone were investigated in 52 relatively young (age range 26-53 years, mean 42.7 years) male depressed outpatients. During 6 weeks of mesterolone treatment, there was a significant improvement of depressive symptomatology. However, since an improvement was also established during the placebo treatment, no statistically appreciable difference in the therapeutic effects of mesterolone was established compared to placebo. Mesterolone treatment significantly decreased both plasma testosterone and protein bound testosterone levels. Patients with high testosterone levels prior to treatment seem to have had more benefit from mesterolone treatment than patients with low testosterone levels. The degree of improvement weakly correlated to the decrease of testosterone levels during mesterolone treatment.



Information confirming no HTPA shutdown/suppression during PCT

These are some research articles that may justify the use of low/moderate dose Proviron during PCT:


--------------------------------------------------------------------------------------------
AAKVAAG, A., and S. B. STROMME. "The effect of mesterolone administration to normal men on the pituitary-testicular function."Acta endocrinologica 77.2 (1974): 380-386.

ABSTRACT
Mesterolone (1***945;-methyl-5***945;-dihydrotestosterone) has been given to 10 normal men, age 24–27 years, and the effect on the plasma levels of ICSH, FSH and testosterone has been studied.No effect on the plasma levels of ICSH and FSH could be detected. After 4 weeks on 75 mg mesterolone per day a significant (P < 0.01) drop in the mean value for plasma testosterone level was observed, 5.2 to 4.0 ng/ml. After another 4 weeks on 150 mg mesterolone per day a further decrease to 3.5 ng/ml was found.During mesterolone administration the protein binding of testosterone in plasma was significantly reduced, and it appeared that the level of free (non-protein bound) testosterone in diluted plasma remained unchanged, 0.37 and 0.41 ng/ml, before and after mesterolone administration respectively.The results suggest that mesterolone given in doses of 75 and 150 mg/day to normal men does not suppress the pituitary ICSH production or the testicular testosterone production
--------------------------------------------------------------------------------------------

GORDON, R.D., THOMAS, M.J., POYNTING, J.M. and STOCKS, A.E. (1975), Effect of Mesterolone on Plasma L.H., F.S.H. and Testosterone. Andrologia, 7: 287–296. doi: 10.1111/j.1439-0272.1975.tb00942.x

Summary
It has been claimed that orally administered mesterolone, unlike l7a-methyl testo- sterone, does not suppress endogenous gonadotrophins and testesterone. To investi- gate this, both drugs were administered, in turn, to four normal men and plasma te- stosterone, L.H. and F.S.H. were measured serially. Mesterolone administration was associated in all four subjects with significant and similar falls in plasma testosterone, but significant suppression of gonadotrophins took place in only two of them. Any changes which occured were apparent by the end of the first week of therapy. Administration of half the dose of 17a-methyl testosterone to the same four subjects caused significant suppression of testosterone in each and suppression of one or both gonadotrophins in each.
In longer term studies in patients (5-30 months) involving serial measurements at intervals of one to two months, there was evidence of significant suppression of L.H. and F.S.H. by 17a-methyl testosterone, but not by mesterolone, which was clinically a less effective androgen.
--------------------------------------------------------------------------------------------

WANG, C., BURGER, H.G., de KRETSER, D.M., DULMANIS, A., HUDSON, B., KEOGH, E.J. and SUTHERS, M.B. (1974), Effect of Mesterolone on Serum FSH, LH and Plasma Testosterone in Normal Men. Andrologia, 6: 111–117. doi: 10.1111/j.1439-0272.1974.tb01604.x

Summary
To determine whether the claim that mesterolone, an orally active androgen, does not cause suppression of gonadotrophin secretion, two groups of five normal men were treated with 100 and 200 mg. daily respectively for 7 days. Serial measurements of serum FSH, LH and plasma testosterone were made on samples taken at 15 minute intervals over 2 hr both before and during treatment. Modest falls in FSH, LH and testosterone levels were observed in both groups, the percentage suppression being 21% and 18% for FSH, 19% and 15% for LH and 9% and 8% for testosterone at the lower and higher dosage levels respectively.
--------------------------------------------------------------------------------------------


200mg is a far greater dose than I would deploy during PCT (50mgs is ideal). From these studies and other articles we see have read, it's clear that there is almost minimal/no influence on the HTPA, any effect would be absolute minimal and negated by other appropriate compounds used during that period (HCG, Aromasin, Nolvadex and HGH)...



Team PSL supervisor
Vision
 
unfortunately I don't feel any effect from proviron like well being etc, maybe little bit better libido but maybe it was just coincidence as it can change every day... i tried underground lab and also pharma grade personally bought from pharmacy.
 
Masteron is a better option for me. Cheaper too

Var will help as well. Just about any DHT derivative will calm most side effects one may get from Tren.
 
unfortunately I don't feel any effect from proviron like well being etc, maybe little bit better libido but maybe it was just coincidence as it can change every day... i tried underground lab and also pharma grade personally bought from pharmacy.

It's one of those compounds that either works for someone or it doesn't, some people are non-responders at the same time there's others that are very sensitive and reap the benefits at a low or moderate dose.... myself on the other hand at 75 is when I really start to feel the effects when I bump it up to 100 that's when things really really improve...

I have tried many undergrounds and only a selected few really caught my attention, I know within a week if the stuff is dosed properly because I began to get a very warm fuzzy feeling...
 
Masteron is a better option for me. Cheaper too

Var will help as well. Just about any DHT derivative will calm most side effects one may get from Tren.

Exactly...all DHT/DHT derivatives posses neurosteroid targeting properties... some guys swear by mast, other prov, this is one of those discussions that can lean heavy on both sides...
 
I ran Masteron @ 800mg on a recent blast, I have to admit, I felt bloody fantastic on the stuff, I'll be using this on most cycles moving forward...
 
I ran Masteron @ 800mg on a recent blast, I have to admit, I felt bloody fantastic on the stuff, I'll be using this on most cycles moving forward...

I agree man, I feel great on Mast. I'm going to add it in at low dose (200mg/wk) on my next blast to see how it goes. I feel it will be beneficial.
 
I agree man, I feel great on Mast. I'm going to add it in at low dose (200mg/wk) on my next blast to see how it goes. I feel it will be beneficial.

Hmmm, I'm not sure how good the effect will be at that low a dose man.... the general consensus seems to be a starting point of 600mg per week.
 
I agree man, I feel great on Mast. I'm going to add it in at low dose (200mg/wk) on my next blast to see how it goes. I feel it will be beneficial.

At a dose that low....you may as well just run proviron. 200mg won't do anything for body composition, so if you're just looking for the mental benefits then proviron would probably suit you better.
 
I ran Masteron @ 800mg on a recent blast, I have to admit, I felt bloody fantastic on the stuff, I'll be using this on most cycles moving forward...

I love the way it makes me feel as well....now if I could run it without getting covered in cystic acne that would be great. I'm running mast E at 800mg currently and I will say that the acne is substantially less than when I run prop. Could be the fact that I'm pinning 200mg 4x a week keeping my levels nice and stable.
 
I love the way it makes me feel as well....now if I could run it without getting covered in cystic acne that would be great. I'm running mast E at 800mg currently and I will say that the acne is substantially less than when I run prop. Could be the fact that I'm pinning 200mg 4x a week keeping my levels nice and stable.

Brother I will use Accutane and believe it or not there's a protocol that I do that is very effective and it does not raise the liver enzymes... pretty much it's a quick blast with Accutane and then you just slightly treated thereafter and you can virtually run any compound that increases the production of sebum tenfold and have smooth skin..

My scalp looks horrendous when I break out it's rather embarrassing and I get the same ones that you mentioned above but my entire head looks like the moon..

When I run that protocol or I use an antibiotic it clears it right up within days...

Accutane 60,60,40,40,20,20...then 10mgs e3d there after.... I even know a gentleman that would take one 20 a week there after and he had amazing results..

It's ironic because it looks like my tamoxifen protocol...

By the way those are days not weeks
 
At a dose that low....you may as well just run proviron. 200mg won't do anything for body composition, so if you're just looking for the mental benefits then proviron would probably suit you better.

Interesting thoughts. In the original post, Vision states that mast is much stronger than proviron. I'm not looking for serious effects on body composition; mainly thought low dose might provide positive mental benefits, lower free estrogen a bit and bind to some SHBG to increase effectiveness of other compounds.

What dose of proviron would you recommend?
 
I ran Masteron @ 800mg on a recent blast, I have to admit, I felt bloody fantastic on the stuff, I'll be using this on most cycles moving forward...
you felt amazing because of the targeting properties that I mentioned above it truly improves the signaling within your neurotransmitters because as we get older they degrade, you get an approved sense of well-being and cognitive thought process much like some people get from growth.... when you utilize mast at low dosage for the particular subject above the results are outstanding but it's better with a long ester... because the levels will build considerably over time

I agree man, I feel great on Mast. I'm going to add it in at low dose (200mg/wk) on my next blast to see how it goes. I feel it will be beneficial.
Hands down one of the best message bro and a matter of fact if you use this concurrent with proviron you get a great synergetic effect, both of the compounds complementing one another at the same time targeting the same receptors...
 
Interesting thoughts. In the original post, Vision states that mast is much stronger than proviron. I'm not looking for serious effects on body composition; mainly thought low dose might provide positive mental benefits, lower free estrogen a bit and bind to some SHBG to increase effectiveness of other compounds.

What dose of proviron would you recommend?

Brother like I said above you are on the right track with this I like your approach, and your approach can be very beneficial if you're utilizing it as an agent to assist rather than using it for its original properties... and like I mentioned running it concurrently with proviron is absolutely outstanding
 
Brother like I said above you are on the right track with this I like your approach, and your approach can be very beneficial if you're utilizing it as an agent to assist rather than using it for its original properties... and like I mentioned running it concurrently with proviron is absolutely outstanding

So maybe 30mg mast/day and 25mg proviron/day?
 
If you are using a heavy ester, 150-200 ew...and 25-50 proved.. the results are outstanding like literally outstanding, definitely worth writing home about...

But the problem therein lies people expect fireworks, they have a preconceived notion for something outstanding far as body composition is concerned, they can expect some results there but nothing dramatic but it's more of a psychological,mental health/ wellness treatment...

Using the compounds individually does bring good results in most users but like I said concurrently disorderly amazing....

Don't expect magic but rather that side effects are more manageable and tolerable
 
If you are using a heavy ester, 150-200 ew...and 25-50 proved.. the results are outstanding like literally outstanding, definitely worth writing home about...

But the problem therein lies people expect fireworks, they have a preconceived notion for something outstanding far as body composition is concerned, they can expect some results there but nothing dramatic but it's more of a psychological,mental health/ wellness treatment...

Using the compounds individually does bring good results in most users but like I said concurrently disorderly amazing....

Don't expect magic but rather that side effects are more manageable and tolerable

This is exactly what I was intending to use it for. Body composition effects are going to come from the other androgens I'll be using. I had just read some of the lesser known effects of mast and theorized it might be worthwhile to add in at a low dose. Your post just verifies that. I'll give it a shot and report back once it's been long enough to gauge effectiveness.
 
This is exactly what I was intending to use it for. Body composition effects are going to come from the other androgens I'll be using. I had just read some of the lesser known effects of mast and theorized it might be worthwhile to add in at a low dose. Your post just verifies that. I'll give it a shot and report back once it's been long enough to gauge effectiveness.

Brother if you in fact do this and report back to the community you will basically be our very own clinical study right before our own eyes with authentic unbiased feedback...

In fact that would be HUGE if you gave detail on what dosages you do and concerning increases or decreases and other suppressed side effects, vs pro long side effects
 
I ran proviron at 100mg and appear to be a non responder . But I think I will try it once more before I give up on it. I was thinking instead of using it on blast I would try it out on TRT to see if I see/feel it working../?? I dont know yet tho
 
good write up regardless...

what sucks is the amount you need... its expensive
 
Back
Top