Relationship between high E2 and blood calcium

[lolque1658]

My E2 had been 261 (range 7-42) when I knew something was wrong and had to get tested. My calcium has also been high @ 11.5 (range 8.6-10.3)

I know theres a relationship between E2, bones and calcium. I don't know if the high E2 is probably the cause of my high calcium. Everything started around the same time, I've been feeling bad for a couple months but its getting better. I dropped the e2 100 points last 2 weeks to 160 and will get another blood next week...

I just need reassurance because I'm worried the high calcium could be something else.. I've been super depressed/anxious past 2 months but Im sure is the e2 cause before I felt perfect. I have a doctor but i don't want to go through multiple tests and what not, not fun plus I'm going on vacation in 2 weeks.

 

[Megatron28]

What are you running? I assume you are on cycle right now.

What is your calcium normally when not on cycle?

I wouldn't panic. Get your E2 under control and see if that brings everything else in line.

 

[JimiThing]

There is a direct correlation between e2 and calcium. Thats why low e2 and even certain serms can cause bone mineral density issues. d bet you'll find getting e2 in line also brings calcium in line as well however you are right to be concerned. You can lower e2 relatively quickly and calcium levels will soon follow so its not like its gonna take long to see if that relationship is the cause.

 

[DreDay187]

There is a direct correlation between e2 and calcium. Thats why low e2 and even certain serms can cause bone mineral density issues. d bet you'll find getting e2 in line also brings calcium in line as well however you are right to be concerned. You can lower e2 relatively quickly and calcium levels will soon follow so its not like its gonna take long to see if that relationship is the cause.

Estrogen is needed for bone density isn't it? Higher E2 would help more than low E2 as there's more E2 to bind to ER in the bone no? Or is too high E2 as bad for home as low e2?

 

[JimiThing]

Estrogen is needed for bone density isn't it? Higher E2 would help more than low E2 as there's more E2 to bind to ER in the bone no? Or is too high E2 as bad for home as low e2?

No your right - High e2 would help. That was my line of thought. He has high e2 and high calcium..coincidence..prob not. Estrogen aids in absorption of calcium (in the intestine) resulting in higher calcium levels.

 

[DreDay187]

No your right - High e2 would help. That was my line of thought. He has high e2 and high calcium..coincidence..prob not. Estrogen aids in absorption of calcium (in the intestine) resulting in higher calcium levels.

Got it. Thanks!

 

[Black Beard]

What are your vitamin D levels? You need vitamin D and vitamin K for proper calcium absorption and metabolism. Vitamin D increases absorption, Vitamin K increases bone deposition. Vitamin D creates Osteocalcin, but you need Vitamin K to carboxylate it so it can do it's job.






Edit: Just learned that estrogen increases vitamin D metabolism and that's the mechanism by which it affects calcium. (As stated by Jimi)

http://www.ncbi.nlm.nih.gov/pubmed/6255005

 

[lolque1658]

What are your vitamin D levels? You need vitamin D and vitamin K for proper calcium absorption and metabolism. Vitamin D increases absorption, Vitamin K increases bone deposition. Vitamin D creates Osteocalcin, but you need Vitamin K to carboxylate it so it can do it's job.






Edit: Just learned that estrogen increases vitamin D metabolism and that's the mechanism by which it affects calcium. (As stated by Jimi)

Effect of estrogen on calcium absorp... [J Clin Endocrinol Metab. 1980] - PubMed - NCBI

I was supplementing with vitD but stopped

I haven't had them tested. Im going for bloods next week so I can add the test

 

[Black Beard]

Just keep the level over 50 ng/ml and under 100 ng/ml

 

[addy]

What are your vitamin D levels? You need vitamin D and vitamin K for proper calcium absorption and metabolism. Vitamin D increases absorption, Vitamin K increases bone deposition. Vitamin D creates Osteocalcin, but you need Vitamin K to carboxylate it so it can do it's job.






Edit: Just learned that estrogen increases vitamin D metabolism and that's the mechanism by which it affects calcium. (As stated by Jimi)

Effect of estrogen on calcium absorp... [J Clin Endocrinol Metab. 1980] - PubMed - NCBI

does this mean high e2 =high vit D??