One thing to think about is alcohol does make on react differently to it as years go by. I can tell you at 30 the difference on how alcohol affects me than when I was 21 is pretty profound. Mainly in recovery not necessarily while Im drinking it. I would throw out having sex lowering your t levels, thats myth buster stuff. But the alcohol could very well be spiking your E, which is something you may just have a choice, either drink and deal with it or not drink. but like said it should be no different than when you werent on T, testosterone replacement therapy (TRT) is not going to make you act differently while on booze. Other things is maybe try a different wine, or different kind of alcohol such as beer or liquor. You may also be dehydrated.
I used to drink miller lite, but one day it gave me a splitting headache after half a beer, and still does if I drink it, so I dont drink it anymore. This is due to be allergic to certain kinds of yeast. Kind of blew my mind but I looked it up, people can gain or have an allergy on certain beer because of the yeast, and maybe the wine is the same way.