steroids and creatinine high

[mirello]

hello guys, I did blood tests all ok, except the creatinine

creatinine min. 60 - max 1.30 my result is 1.80

should I be concerned? I have a kidney problem? I have to suspend use of steroids?

I am very worried I'm afraid, what happens to my kidneys?

p.s. I've never used creatine

 

[Megatron28]

Yes, that is a sign of a potential problem with your kidneys if they are not clearing out creatinine. Are you taking any blood preasure medication? I know lisinopril can increase that some, but usually not that much. How much water are you drinking daily. And what compounds are you running?

 

[mirello]

I only used test E for 14 weeks

 

[mirello]

I only used test E for 14 weeks, the test E, may be the cause?

 

[mirello]

hello guys

between test E, and anavar , which of these two is more harmful to the kidneys ?

 

[halfwit]

hello guys

between test E, and anavar , which of these two is more harmful to the kidneys ?

They're both metabolized by the liver, but if I had to guess - I'd say the var being an oral is slightly worse on the renal system. 1.8 isn't something I'd freak out about; you were likely dehydrated and as a blood test is just a snap-shot in time, you're probably fine. I'd make sure to increase your water intake and see how you do in a few weeks.

Of course I'm not a doctor, and my advice should not be considered a replacement of such from a trained physician.

My .02c

 

[mirello]

I have heard that anavar is an oral low toxicity, and that is not a danger to the kidneys, is this true?

 

[Megatron28]

I have heard that anavar is an oral low toxicity, and that is not a danger to the kidneys, is this true?

Anavar is processed by the liver.

 

[mirello]

then, in principle, only use test E, however, is less harmful to the kidneys and liver , compared to anavar, is this correct?

 

[Megatron28]

then, in principle, only use test E, however, is less harmful to the kidneys and liver , compared to anavar, is this correct?

I don't understand. Can you please rephrase the question.

 

[alexh1]

it is because its an injectable they are always less harmful then orals?
if thats what you meant by the question?

 

[ksvc]

AAS seem to effect the kidneys negatively. Look up FSGS in bodybuilders. In summary, long term use of AAS is implicated in kidney dysfunction that can eventually result in kidney failure.

You need a repeat draw, though.

 

[Megatron28]

AAS seem to effect the kidneys negatively. Look up FSGS in bodybuilders. In summary, long term use of AAS is implicated in kidney dysfunction that can eventually result in kidney failure.

You need a repeat draw, though.

Not all AAS is the same.

 

[ksvc]

Not all AAS is the same.

The authors implied that nephrotoxicity could be a result of androgenic stimulation, so if that were the case, AAS can be considered somewhat equivalent. There are obviously other factors to consider; for instance, high protein diets consumed by bodybuilders tend to increase GFR.

The data at this point is merely correlational and the mechanisms putative. Future work should shed more light on this

 

[Megatron28]

Can you post the study? Lets read it.

 

[ksvc]

J Am Soc Nephrol. 2010 Jan;21(1):163-72. doi: 10.1681/ASN.2009040450. Epub 2009 Nov 16.
Development of focal segmental glomerulosclerosis after anabolic steroid abuse.
Herlitz LC1, Markowitz GS, Farris AB, Schwimmer JA, Stokes MB, Kunis C, Colvin RB, D'Agati VD.
Author information
Abstract

Anabolic steroid abuse adversely affects the endocrine system, blood lipids, and the liver, but renal injury has not been described. We identified an association of focal segmental glomerulosclerosis (FSGS) and proteinuria in a cohort of 10 bodybuilders (six white and four Hispanic; mean body mass index 34.7) after long-term abuse of anabolic steroids. The clinical presentation included proteinuria (mean 10.1 g/d; range 1.3 to 26.3 g/d) and renal insufficiency (mean serum creatinine 3.0 mg/dl; range 1.3 to 7.8 mg/dl); three (30%) patients presented with nephrotic syndrome. Renal biopsy revealed FSGS in nine patients, four of whom also had glomerulomegaly, and glomerulomegaly alone in one patient. Three biopsies revealed collapsing lesions of FSGS, four had perihilar lesions, and seven showed > or =40% tubular atrophy and interstitial fibrosis. Among eight patients with mean follow-up of 2.2 yr, one progressed to ESRD, the other seven received renin-angiotensin system blockade, and one also received corticosteroids. All seven patients discontinued anabolic steroids, leading to weight loss, stabilization or improvement in serum creatinine, and a reduction in proteinuria. One patient resumed anabolic steroid abuse and suffered relapse of proteinuria and renal insufficiency. We hypothesize that secondary FSGS results from a combination of postadaptive glomerular changes driven by increased lean body mass and potential direct nephrotoxic effects of anabolic steroids. Because of the expected rise in serum creatinine as a result of increased muscle mass in bodybuilders, this complication is likely underrecognized.

full text: ncbi.nlm.nih.gov/pmc/articles/PMC2799287/

 

[Megatron28]

Does it say what they were running? Tren? Test? Orals? Like you said, what about protein consumption? Where's the identification of cause and effect?

 

[Mrrippedzilla]

Does it say what they were running? Tren? Test? Orals? Like you said, what about protein consumption? Where's the identification of cause and effect?

Its a pretty poor study with no cause and effect, here's a table of what the guys were using/protein intake, etc:

PubMed Central, Table 1.: J Am Soc Nephrol. Jan 2010; 21(1): 163?172. doi:*10.1681/ASN.2009040450

Alot of the patients supplemented with creatine (some over 10g per day) and had very high protein diets (one had over 500g protein per day).

The only thing I can conclude from the study is that FSGS is caused by weight gain, which isn't a suprise, and not by the AAS use per se.
Its more a case of AAS use along with other factors > weight gain > FSGS.

 

[ksvc]

There's a table in the full text that outlines (albeit incompletely) what each of the 10 subjects took.

I never said there was a cause and effect - I said that AAS were implicated in renal dysfunction in bodybuilders via hypothetical mechanisms involving the androgen receptor. There's still a lot to be fleshed out in terms of the research and the study has its limitations (small, uncontrolled sample size). My point to the OP was that it's not unreasonable, based on what is known on the subject, to think AAS could have an effect on renal values. Being aware of that could help him get his health back, if indeed there was a problem.