cybrsage
New member
Tesofensine...no, I did not miss a T there as the fourth letter...this is NOT a testosterone increasing drug. What is it then, why should you care? It is a weight loss drug. A VERY potent one. How potent? TWICE as powerful as the current prescription drugs on the market! But I have jumped to the end of the story already. Lets start at the beginning.
Under development by NeuroSearch, a Danish pharmaceutical company, tesofensine is a serotonin-noradrenaline-dopamine reuptake inhibitor. It was originally in development for the treatment of neurological disorders such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). It failed miserably at doing anything for PD and AD, but the scientists noticed that everyone who used Tesofensine lost weight - a LOT of weight. So they reclassified the drug and started trials all ove again. Yes, they had to start at the beginning again even though they alredy did some human trials, but that is because they changed the purpose of the drug.
Trials on mice were done and they mice all lost weight, except those on the plecebo, they did not. They made mice fat using DIO. What is DIO? It literally stands for Diet Induced Obesity. They overfed the mice using a super high fat diet and, naturally, the mice became fat. They then used tesofensine on some of the mice and noticed they stopped eating as much as the other mice. They then injected the mice with something that made them feel hungry after being injected, to force them to eat as much as the other mice, and they went back up to the same weight as the other mice.
What does this tell us? Tesofensine makes you lose weight because it makes you eat less food each time you eat and eat less often. We all know that the difference between your goes-insa and goes-outsa causes your weight to increase or decrease (more in than out, weight increases...more out than in, weight decreases). This can be done by decreasing the in, increasing the out, or a combination of the two.
They then did human trials. Wait, what? HUMAN trials already? Yes. They were allowed to move quickly since they already used this stuff on humans before and no one got sick or died.
They found that people said they felt satiated sooner while eating, and felt satiated longer after eating. There is a lot of science that goes on to explain how this most likely works, and you can find it in my source links at the end if you are so inclinded to read up on it.
There is more to it than hunger control, though. The studies found that energy expendiature was increased as well; the basal metabolic rate went up. They know this because the mice became accustomed to the hunger control. In other words, some of the mice got used to feeling like they were not hungry and decided to increase the amount they ate anyway. But even when that happened, the subjects on tesofensine still remained at a lower weight than the plecebo group even though their food intake was back up to where it was before. This started at 14 weeks of use and continued forever. The interesting thing is that they did NOT see this in the human trials. Go figure, humans and mice are different.
What about side effects? Great question. There are none. Well, not quite true, there is one. Heart rate increased by about 7bps at about 3 months of use but did not increase any more after that. It also had the same side effects as the plecebo had - dry mouth, headaches, etc. The stuff you read about on the back of every single over the counter drug you buy. So only a slight increase in heart rate, which is still just a small increase. This is amazing, considering the currently accepted precription drugs for weight loss have tons of side effects.
161 (79%) participants completed a 24 week study. The mean weight loss produced by diet and placebo was 2.0% (SE 0.60). Tesofensine 0.25 mg, 0.5 mg, and 1.0 mg and diet induced a mean weight loss of 4.5% (0.87), 9.2% (0.91), and 10.6% (0.84), respectively, greater than diet and placebo (p<0.0001). After 24 weeks, tesofensine 0.25 mg and 0.5 mg showed no significant increases in systolic or diastolic blood pressure compared with placebo, whereas heart rate was increased by 7.4 beats per min in the tesofensine 0.5 mg group (p=0.0001).
Tesofensine is ready for Phase III trials, which will test its use on unhealthy people, people on other drugs, verify previous results, etc. After that, it will appear on the market for consumption.
I LOVE this stuff! I know you guys will to! Just make sure you only take it during a cut since it will decimate your appetite. It would be AMAZING to run in combination with GW50, which will boost your endurance.
References
Tesofensine Anti-Obesity Medication - Drug Development Technology
https://www.nature.com/articles/npp201016
https://www.ncbi.nlm.nih.gov/pubmed/18950853?dopt=Abstract&holding=npg
Under development by NeuroSearch, a Danish pharmaceutical company, tesofensine is a serotonin-noradrenaline-dopamine reuptake inhibitor. It was originally in development for the treatment of neurological disorders such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). It failed miserably at doing anything for PD and AD, but the scientists noticed that everyone who used Tesofensine lost weight - a LOT of weight. So they reclassified the drug and started trials all ove again. Yes, they had to start at the beginning again even though they alredy did some human trials, but that is because they changed the purpose of the drug.
Trials on mice were done and they mice all lost weight, except those on the plecebo, they did not. They made mice fat using DIO. What is DIO? It literally stands for Diet Induced Obesity. They overfed the mice using a super high fat diet and, naturally, the mice became fat. They then used tesofensine on some of the mice and noticed they stopped eating as much as the other mice. They then injected the mice with something that made them feel hungry after being injected, to force them to eat as much as the other mice, and they went back up to the same weight as the other mice.
What does this tell us? Tesofensine makes you lose weight because it makes you eat less food each time you eat and eat less often. We all know that the difference between your goes-insa and goes-outsa causes your weight to increase or decrease (more in than out, weight increases...more out than in, weight decreases). This can be done by decreasing the in, increasing the out, or a combination of the two.
They then did human trials. Wait, what? HUMAN trials already? Yes. They were allowed to move quickly since they already used this stuff on humans before and no one got sick or died.
They found that people said they felt satiated sooner while eating, and felt satiated longer after eating. There is a lot of science that goes on to explain how this most likely works, and you can find it in my source links at the end if you are so inclinded to read up on it.
There is more to it than hunger control, though. The studies found that energy expendiature was increased as well; the basal metabolic rate went up. They know this because the mice became accustomed to the hunger control. In other words, some of the mice got used to feeling like they were not hungry and decided to increase the amount they ate anyway. But even when that happened, the subjects on tesofensine still remained at a lower weight than the plecebo group even though their food intake was back up to where it was before. This started at 14 weeks of use and continued forever. The interesting thing is that they did NOT see this in the human trials. Go figure, humans and mice are different.
What about side effects? Great question. There are none. Well, not quite true, there is one. Heart rate increased by about 7bps at about 3 months of use but did not increase any more after that. It also had the same side effects as the plecebo had - dry mouth, headaches, etc. The stuff you read about on the back of every single over the counter drug you buy. So only a slight increase in heart rate, which is still just a small increase. This is amazing, considering the currently accepted precription drugs for weight loss have tons of side effects.
161 (79%) participants completed a 24 week study. The mean weight loss produced by diet and placebo was 2.0% (SE 0.60). Tesofensine 0.25 mg, 0.5 mg, and 1.0 mg and diet induced a mean weight loss of 4.5% (0.87), 9.2% (0.91), and 10.6% (0.84), respectively, greater than diet and placebo (p<0.0001). After 24 weeks, tesofensine 0.25 mg and 0.5 mg showed no significant increases in systolic or diastolic blood pressure compared with placebo, whereas heart rate was increased by 7.4 beats per min in the tesofensine 0.5 mg group (p=0.0001).
Tesofensine is ready for Phase III trials, which will test its use on unhealthy people, people on other drugs, verify previous results, etc. After that, it will appear on the market for consumption.
I LOVE this stuff! I know you guys will to! Just make sure you only take it during a cut since it will decimate your appetite. It would be AMAZING to run in combination with GW50, which will boost your endurance.
References
Tesofensine Anti-Obesity Medication - Drug Development Technology
https://www.nature.com/articles/npp201016
https://www.ncbi.nlm.nih.gov/pubmed/18950853?dopt=Abstract&holding=npg
