Testosterone deficiency impairs the response to phophodiesterase-5 inhibitors in patients with erectile dysfunction.
In hypogonadal men, testosterone replacement was associated with enhanced sexual function in patients who failed initial treatment with Sildenafil or Tadalafil.
The most widely accepted cut-off below which hypogonadism is diagnosed is a serum testosterone level <300 ng/dL (10.4 nmol/L).
Combination therapy is safe and could be beneficial for men with low testosterone who failed monotherapy.
