Testosterone decay & blood levels - excel sheet

[buffg]

Hi All,

Im plannign my next cycle with Sustanon (previously only did test e) and wanted to see how the stability of blood levels compared with e and other single esthers so I put together an excel sheet to the best of my ability that uses the basic decay formula to try to determine blood levels throughout a cycle of both sust and single esther tests (also for post cycle therapy (pct) planning, when to start)

Please use it as you wish and leave any feedback so I can adjust to hopefully make it more accurate.

One big point here is I assume in the model that basically on the day of injection all that test is immediately available, i suppose there is some time before the test is absorbed but according to this website: (Medibolics), its not long.

The excel file is available for download here:
<Removed from public download, PM me if you want the file...>

change only numbers in blue, all black numbers are calculated.

Hope this helps someone, if you have any questions or feedback leave a reply.

 

[couch]

You misunderstand. Because of esters/depots, the test is not immediately available after inject.

 

[buffg]

Ok so if i have a half-life of 9 days its not simply following exponential growth and decay formula (N(t) = N0e^-lt)? So if you have test with hl of 9 days at T=0 you have say 250 mg available, and at t=4.5 you have 125 mg available?

What about the info on that medibolics link? it seems to indicate that basically after ~1 day its at peak levels then "dissolves" from there...

 

[Moppy1]

Dude, just inject 2x a week with enanthate and cypinate esters and your levels will be essentially constant, and then you don't have to worry about that half-life shit.....

 

[buffg]

Dude, just inject 2x a week with enanthate and cypinate esters and your levels will be essentially constant, and then you don't have to worry about that half-life shit.....

yea... that makes sense, no need to over analyze it i suppose...

 

[Moppy1]

All good

 

[couch]

Ok so if i have a half-life of 9 days its not simply following exponential growth and decay formula (N(t) = N0e^-lt)? So if you have test with hl of 9 days at T=0 you have say 250 mg available, and at t=4.5 you have 125 mg available?

What about the info on that medibolics link? it seems to indicate that basically after ~1 day its at peak levels then "dissolves" from there...

So this part is tricky. For a half-life of 10 days, we know that at 10 days, we have half our total dose. So assuming 100mg, we have;

day 10: 50
day 20: 25
day 30: 12.5

and so on. But the ramp up is not clear, and I have not been able to find good explanations of bioavailability. The easy way to cheat this would be to say it's linear, but what happens in the case that I hit 600mg of cyp? For the sake of argument, let's say it has a hl of 10 days. Does this mean on day 5 I've got 150mg available, day 10 I've got 300mg available, and so on? My experience tells me this is not the way it works.

Anyways, what I'm getting at is the ramp down is easy to plot. The ramp up is trickier.

Moppy is correct that it's easier to just work with long esters, pin regularly, and so on. The problem is when you start mixing esters. So in my case, next blast will include:

TNE
tren ace
tren e
sust
var (or maybe adrol, don't know)
halo

I'd like to be able to plot these things out myself because I've got competitions I want to plan blood levels for. I think the work you're doing is important, but I haven't found a lot of resources for figuring these curves out.

 

[noway55]

you are right, testosterone doesn't live forever. blood concentrations of test e are good to know, but what you really care about is how much test is released per day.

something i posted on another forum.

okay, so after doing a bit of thinking about this it occured to me that we're really chasing after the wrong thing here. knowing the amount of the compound in your blood is good to know, but what we really care about in terms of managing sides/seeing how long it takes to kick in is how much testosterone is being released by the esters daily

I did a little bit of tinkering and here are some graphs

again, assuming a weekly dose of 500mg test e and a half life of 7 days

ED

in reality this isn't a straight line, but when you do the calculation with days as the time scale it turns out like this. you'd see some slight bumps if i did everything in terms of hours, but you get the idea. the fluctuation here is on an hourly timescale, not daily..pretty much equal amounts released daily
EOD

E3D

E4D

keep in mind this isn't adjusted for the fact that test e isn't 100% test and the ester weighs a little, but that's not really that important...your typical dosing 2x a week will bring you somewhere between E3D and E4D

tbh this is a lot less drastic, in the most extreme case the variation of daily test released is only 20 mg...no biggie at all. But if you want as stable blood levels as you can get, pin ED or EOD. this also explains to me why test e and c take so long to kick in, the weekly dosages go roughly like this if you dose it E3D:

week 1: 150mg
week 2: 340mg
week 3: 415mg
week 4: 450mg
week 5: 485mg
week 6: 490 mg
...
(Note: if you assume a half life of enanthate as 10 rather than 7 then these numbers are lower and it takes a bit longer to work up to the higher dose)
it actually tends to hover around 490 rather than 500, interesting...guessing the little but under 500 gets accounted for at the end once you stop pinning or stop blasting

these graphs right here are key, the other ones are good but these are better. they were actually really insightful for me...what's really cool is that you can get realllly stable blood levels because of the long half life by pinning compounds with enanthate esters ED or EOD... you'd have to pin acetates or props multiple times daily to get this kind of stability. if you suffer with sides from things like tren a maybe you should try pinning tren e instead with the same frequency

this doesn't account for bioavability or other facts, its based purely on half life. however, i think those types of things would only have slight effects, and that all the above info is still useful

another thing - when people say something like test e reaches peak blood concentration after one day, it doesn't really matter because it's still attached to the ester. i guess technically that applies to the test concentration as well, but thats just because drugs decompose following exponential decay. since anything decaying exponential is always decreasing, the rate of test being released by any shot is always decreasing

 

[couch]

How are you plotting the "up" line? It looks like you're assuming the ramp up is linear.

 

[noway55]

there is no ramp up, it's a bunch of discrete points connected together with a line for your viewing pleasure

 

[noway55]

okay, a less smart ass reply:

the data available for half lives is in days, most people pin on a timescale of days so the daily amount of ester released per day is what we care about

i made the graph that used decay formulas with days as the timescale

adding more points doesn't make sense because it's graphing discrete data i can put points in every .5 days instead of every day, but that artificially inflates the total amount of test released per day (there'd be a point between days, where does that go? )

you can make the graph become more continuous by making the timescale in hours, then you could get more points that make sense. however this is overkill because the half life data would not be very reliable in terms of hours, and most people are not pinning themselves multiple times a day, so knowing how much test is released per hour isn't really worth knowing

you could be even more extreme and make the time scale in seconds, but you'd pretty much have to connected to an iv drip to care, and good luck with reliable half life time

 

[buffg]

Just to chime back in here, i agree with noway's take on things. After a bit more research (great article here Testosterone Ester Report), ive reasoned that it still follows the growth / decay formula, kind of like this: if you start with 250mg (going back to our 10 day hl example) by day 5 you have 125 left "depo'd", so what happened to the other half? Im guessing it got absorbed, but not linearly, also following logarithmic decay (or growth). So:

Day Remaining absorbed (or metabolized per day) (for lack of better terms)
1.....250............0
2.....231.52.......18.48
3.....214.41.......17.11
4.....198.57.......15.84
... and so on


And as you inject another 250 mg dose you have a larger "depot" and the breakdown continues to release test... I updated the excel sheet if youre curious. The graph looks the same though.

Again i agree just take a long esther like enth 2x / week and dont worry about it but its just because im curious and enjoying the research and thinking into it so i thought id share it...

 

[juced_porkchop]

I also rec 2X a week with cyp or teste to aviod hassle or worry.

 

[buffg]

I also rec 2X a week with cyp or teste to aviod hassle or worry.

2x

Yea, no doubt thats the way to go, just having fun trying to understand it a bit better and having fun playing around with it...