Why is testosterone replacement therapy (TRT) so much higher than natural production?

[miller98b]

I am curious about the argument that people with higher body fat aromitize testosterone more. I aromotize more than anyone I know and I have always been an ectomorph. Never over 10% BF. Does body fat really have something to do with it? I am also curious about dosage for people with a very high metabolism. These may also mostly be ectomorphic body styles. I don't mean to high jack your thread, but I think I am within the discussion parameters. With Antibiotics, it takes me 300% normal of a dose to achieve blood serums levels of the average person takig 1/3 my dose. Is exogenus testosterone somehow metabolized faster with different metabolic rates? Ectomorphs vs endopmorphs?

Yeah, I'm an endomorph with 26.67% BF at 6'3 and 275 pounds. My E2 levels were recently at 80 on a normal scale of 10-40. The theory that bigger guys with more body fat aromatize (sp?) more seems acurate. From my research, the enzyme that causes aromitization is stored in fat cells and the more fat you have, especially in the belly area, the more you need an Aromatase inhibitor (AI). So if you are looking for practical evidence....I'm one.

 

[methos]

And I am the opposite. LOL Before testosterone replacement therapy (TRT) my Total E was 128 and SHBG 65.
I must have had something else going on.

 

[THE-DET-OAK]

I am curious about the argument that people with higher body fat aromitize testosterone more. I aromotize more than anyone I know and I have always been an ectomorph. Never over 10% BF. Does body fat really have something to do with it? I am also curious about dosage for people with a very high metabolism. These may also mostly be ectomorphic body styles. I don't mean to high jack your thread, but I think I am within the discussion parameters. With Antibiotics, it takes me 300% normal of a dose to achieve blood serums levels of the average person takig 1/3 my dose. Is exogenus testosterone somehow metabolized faster with different metabolic rates? Ectomorphs vs endopmorphs?

Yes, a higher bodyfat will increase your chances of aromatizing. This is because the aromatase enzyme hangs out in dense lipid cells (fat cells). So the more fat cells you have, there is a good chance you have more aromatase enzymes.

This does not mean that someone with low body fat can not have a high rate of aroma. There are many other reasons someone can aromatize too much, for instance:

Poor Methylation
Malabsorption (especially zinc)
Age
Diet
Etc