Damn straight, listen to your body though. I only generally take friday off when im on cycle. I hit my legs twice a week and everything else once.
If I need an extra day or two or three off Ill take them, but I know my body and I dont feel I need much time off when I cycle. I dont subscribe to the extreme over training hype, when you are on crank you kind of have to over train to get the full benefit.
Always listen to your body!