Stone
Hazardous
Came across this thread at SM by Spidey and thought it was extremely interesting...
This thread is strictly for entertainment purposes. I do not use or condone the use of illegal drugs. I have not performed these syntheses, nor will I consider doing so.
BOLDENONE CYPIONATE (fast acting EQ)
Step 1: 1-Test cyp is brominated in the 4 position with 2,4,4,6-tetrabromocyclohexa-2,5-dione in ether with catalytic HCl. The product is 4-bromo-1-testosterone cypionate. There are other methods to achieve this bromination as well but this one should work very cleanly with a minimum of side reactions.
Step 2: the bromide is eliminated to give the 4,5-double bond by stirring the above product in DBU for 10 to 20 minutes. The overall yield of bold cyp should be around 75 to 80%
METHANDROSTENOLONE (dbol)
Step 1: The bold cyp from above is stirred in boiling benzene with ethylene glycol and catalytic acid. A Dean-Stark trap should be used to remove water as it is formed. This protects the 3-one as an ethylene ketal.
Step 2: The above protected bold cyp is stirred in boiling methanol/water with NaOH to remove the cyp ester.
Step 3: The 17-OH is oxidized to a ketone with any of a variety of chromium VI reagents.
Step 4: The above 17-one is reacted with methyl magnesium iodide. The reaction is quenched with water and acid. Heating the mixture with the water and acid will remove the ethylene ketal as well, leaving you with methandrostenolone.
METHENOLONE CYPIONATE (Primobolin, although real primo is the enanthate, not the cypionate, I expect little difference in function.
Step 1: 1-Test cyp is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with liquid bromine. The product is 2-bromo-1-methyl-DHT.
Step 2: The bromine is eliminated to give back the 1,2-double bond by stirring with DBU as in the synthesis of bold cyp. The product is methenolone cypionate.
MESTEROLONE (proviron)
1-Test base is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with water to afford mesterolone in a single step.
OXANDROLONE (Anavar)
Step 1: Starting with 1-test base, the 3-one is protected as the ethylene ketal as in the above synthesis of methandrostenolone.
Step 2: The 17-OH is oxidized to a 17-one with chomium VI reagent.
step 3: The 17-methyl is attached with methyl magnesium iodide and the crude reaction mixture is treated with water and acid to quench the reaction and remove the ketal protecting group. The product is 17-methyl-1-test.
Step 4: the 17-methy-1-test is treated with ozone in methanol and then NaOH is added. This allows the purification of the intermediate by recrystallization of the sodium salt. The result is that the double bond is cleaved to give a carboxyolic acid (salt) on one side and an aldehyde on the other. The salt is dissolved in water and acidified to pH=4. NaBH4 is added to reduce the intermediate aldehyde. The resulting alcohol will spontaniously close with the carboxylic acid to give the desired lactone ring. The product is oxandrolone.
OXYMETHYLONE (Anadrol)
17-methyl-1-test from above is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with N-formylmorpholine to give oxymethylone as the product.
DROMOSTANOLONE propionate (Masterone)
Step 1: 1-test base is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with methyl iodide to install the 2-methyl group.
Step 2: the dromostanolone resulting from step 1 is esterified with propanoyl chloride and pyridine to afford the product, masterone.
Of course, since we all know that 1-test is bunk and isn't a REAL steroid to begin with, non of the derivatives above are REAL steroids either, LOL.
STENBOLONE
1-Test base is treated with metachloroperbenzoic acid (MCPBA) to make an epoxide from the 1,2-double bond.
The above epoxide is treated with dimethyl lithium cuprate (installs 2-methyl by opening eopxide ring) followed by acid and heat (to eliminate the 1-OH formed in the previous step and regenerate 1,2-double bond). The product is 2-methyl-1-test (stenbolone).
STANOZOLOL (winstrol)
1 step from oxymethylone prepared in original post.
Oxymethylone is treated with hydrazine to form the pyrazine ring. Voila! Winny.
TEST FROM CHOLESTEROL
Cholesterol is treated with CrO3, acid, and heat to cleave the 17-alkyl chain and turn it into a 17-one. This will simultaniously oxidize the 3-OH to a 3-one and isomerize the double bond into conjugation. The product is 4-androstendione.
Reduction with LiAlH4 will reduce both carbonyls to give 4-androstendiol. Oxidation of the allylic 3-OH with MnO2 affords testosterone.
Now go to work fellas...
This thread is strictly for entertainment purposes. I do not use or condone the use of illegal drugs. I have not performed these syntheses, nor will I consider doing so.
BOLDENONE CYPIONATE (fast acting EQ)
Step 1: 1-Test cyp is brominated in the 4 position with 2,4,4,6-tetrabromocyclohexa-2,5-dione in ether with catalytic HCl. The product is 4-bromo-1-testosterone cypionate. There are other methods to achieve this bromination as well but this one should work very cleanly with a minimum of side reactions.
Step 2: the bromide is eliminated to give the 4,5-double bond by stirring the above product in DBU for 10 to 20 minutes. The overall yield of bold cyp should be around 75 to 80%
METHANDROSTENOLONE (dbol)
Step 1: The bold cyp from above is stirred in boiling benzene with ethylene glycol and catalytic acid. A Dean-Stark trap should be used to remove water as it is formed. This protects the 3-one as an ethylene ketal.
Step 2: The above protected bold cyp is stirred in boiling methanol/water with NaOH to remove the cyp ester.
Step 3: The 17-OH is oxidized to a ketone with any of a variety of chromium VI reagents.
Step 4: The above 17-one is reacted with methyl magnesium iodide. The reaction is quenched with water and acid. Heating the mixture with the water and acid will remove the ethylene ketal as well, leaving you with methandrostenolone.
METHENOLONE CYPIONATE (Primobolin, although real primo is the enanthate, not the cypionate, I expect little difference in function.
Step 1: 1-Test cyp is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with liquid bromine. The product is 2-bromo-1-methyl-DHT.
Step 2: The bromine is eliminated to give back the 1,2-double bond by stirring with DBU as in the synthesis of bold cyp. The product is methenolone cypionate.
MESTEROLONE (proviron)
1-Test base is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with water to afford mesterolone in a single step.
OXANDROLONE (Anavar)
Step 1: Starting with 1-test base, the 3-one is protected as the ethylene ketal as in the above synthesis of methandrostenolone.
Step 2: The 17-OH is oxidized to a 17-one with chomium VI reagent.
step 3: The 17-methyl is attached with methyl magnesium iodide and the crude reaction mixture is treated with water and acid to quench the reaction and remove the ketal protecting group. The product is 17-methyl-1-test.
Step 4: the 17-methy-1-test is treated with ozone in methanol and then NaOH is added. This allows the purification of the intermediate by recrystallization of the sodium salt. The result is that the double bond is cleaved to give a carboxyolic acid (salt) on one side and an aldehyde on the other. The salt is dissolved in water and acidified to pH=4. NaBH4 is added to reduce the intermediate aldehyde. The resulting alcohol will spontaniously close with the carboxylic acid to give the desired lactone ring. The product is oxandrolone.
OXYMETHYLONE (Anadrol)
17-methyl-1-test from above is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with N-formylmorpholine to give oxymethylone as the product.
DROMOSTANOLONE propionate (Masterone)
Step 1: 1-test base is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with methyl iodide to install the 2-methyl group.
Step 2: the dromostanolone resulting from step 1 is esterified with propanoyl chloride and pyridine to afford the product, masterone.
Of course, since we all know that 1-test is bunk and isn't a REAL steroid to begin with, non of the derivatives above are REAL steroids either, LOL.
STENBOLONE
1-Test base is treated with metachloroperbenzoic acid (MCPBA) to make an epoxide from the 1,2-double bond.
The above epoxide is treated with dimethyl lithium cuprate (installs 2-methyl by opening eopxide ring) followed by acid and heat (to eliminate the 1-OH formed in the previous step and regenerate 1,2-double bond). The product is 2-methyl-1-test (stenbolone).
STANOZOLOL (winstrol)
1 step from oxymethylone prepared in original post.
Oxymethylone is treated with hydrazine to form the pyrazine ring. Voila! Winny.
TEST FROM CHOLESTEROL
Cholesterol is treated with CrO3, acid, and heat to cleave the 17-alkyl chain and turn it into a 17-one. This will simultaniously oxidize the 3-OH to a 3-one and isomerize the double bond into conjugation. The product is 4-androstendione.
Reduction with LiAlH4 will reduce both carbonyls to give 4-androstendiol. Oxidation of the allylic 3-OH with MnO2 affords testosterone.
Now go to work fellas...
