100mg cypionate per week. Anyone know what to expect?
- Thread starter LateStart
- Start date
Entourage_Doc
New member
The reason for taking HCG during TRT is LH (or HCG as its analog) is principally responsible for activating the P450 enzyme which converts Cholesterol into Pregnenolone which not only supports adrenals but all 3 metabolic pathways during treatment.
any dose of testosterone/hcg will suppress lh and fsh
Dr B.
any dose of testosterone/hcg will suppress lh and fsh
Dr B.
My doc avoids hcg due to estrogen. You think it's worth fighting the estro in order to receive the other benefits? Sounds like it is from what you're saying. Every time I think I have a handle on my treatment I learn something and change my mind. 
Thanks to all for helping me keep my head in this every day
Thanks to all for helping me keep my head in this every dayHCG induced estrogen is an internet myth
Thank you!
Entourage_Doc
New member
I always included hcg in therapy. The benefits are just too high to exclude. Listen, most providers that do not practice TRT (family medicine, urology, endo) rely on old research and are pretty well stuck in their ways. TRT tends to be more progressive with new research appearing every day. That is all we do at our practice and thats why we are the best.
As another sponsor said on here, practitioners that do not include hcg are old-school and not well versed in our specialty. I have never had ANY issues with a patient on HCG and the efficacy is more than appropriate.
Dr. B
As another sponsor said on here, practitioners that do not include hcg are old-school and not well versed in our specialty. I have never had ANY issues with a patient on HCG and the efficacy is more than appropriate.
Dr. B
My doc admits that much of trt is just trying to find out what is best for the individual......without putting their health at further risk than it would be without treatment. My nat test was 575 but treatment has improved all aspects of my life, even at my low dose. This stuff is so confusing. Thanks again to everyone who has given comments and advice. You have made me think even more about my treatment and I have faith I will find the right formula for me. I will report back all changes, both for advice and to hopefully help others the way all of you have helped me. Please keep up the good work. There are so many out there that need help
Entourage_Doc
New member
Latestart, very well said. It really is individualized, however most patients do well on the same regime. Everybody's chemistry is different, as the genetics and dna makeup really play factors on the metobolization of the compounds.
Glad to hear you are feeling better, TRT is truly a life changer!
Dr. B
Glad to hear you are feeling better, TRT is truly a life changer!
Dr. B
scorob777
New member
Dr. B, there was some discussion on this site a while ago where Detoak was suggesting that 250 IU of HCG is not enough to be effective. He was suggesting once a week at 500 IU is better than 2x per week at 250 IU.
What are your thoughts on best dosage regime? Are there any blood test markers you look at to raise or lower HCG dose?
Entourage_Doc
New member
It all depends on the patient. In a new patient I want them to start at 250iu weekly to see if this lowest effective dose will provide the results we want. HCG will purposefully help restore testicular function at only 250iu weekly. Now, some patients that have been on TRT for a while with no hcg we can do the same as their immunity should be low enough to produce desired effects. With patients that have been on HCG for long periods of time we will bump them up to 500 and keep them their as this will most likely be the lowest effective dose given immunity.
when it comes to labs, your T markers are already so clouded with the synthetic exogenous testosterone that is merely impossible to see any changes. The best way to determine effective dose is testicular size, once you understand that this has been restored you know the dose is clinically ok.
Dr. B
when it comes to labs, your T markers are already so clouded with the synthetic exogenous testosterone that is merely impossible to see any changes. The best way to determine effective dose is testicular size, once you understand that this has been restored you know the dose is clinically ok.
Dr. B
IMT staff
Official Sponsor
Well there are multiple ways to do it but we have found through trial and error that 500IU is the minimum dosage we like to do at a time if you are only injecting it twice per week.
Larry Lipschultz did a study on this and gave men 200mg of TE per week:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378070/
So basically a dosage of 125 IU QOD or 437 IU's per week still left 25% of the group suppressed. For the 250 IU QOD (875IU per week) dosage it still left 7% of the men suppressed. It wasn't until a dosage of 500 IU QOD did the researchers see a full override of suppression bumping TT levels from baseline, which is 1,750 per week.
So this is why we start at 1,000 a week and go up. Unfortunately testicular volume is a tough gauge, since the leydig cells only make up 10% of the testes.
Hope this helps.
Larry Lipschultz did a study on this and gave men 200mg of TE per week:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378070/
So basically a dosage of 125 IU QOD or 437 IU's per week still left 25% of the group suppressed. For the 250 IU QOD (875IU per week) dosage it still left 7% of the men suppressed. It wasn't until a dosage of 500 IU QOD did the researchers see a full override of suppression bumping TT levels from baseline, which is 1,750 per week.
So this is why we start at 1,000 a week and go up. Unfortunately testicular volume is a tough gauge, since the leydig cells only make up 10% of the testes.
Hope this helps.
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Dreaded Pirate Roberts
Administrator
You will need the HCG for progesterone production down the road . I recommend it from the start. It helps with digestion and helps keep the lead in the pencil.
Mr P
,
Tell me about it old school way we didn't know of hcg, I guess I understand why my nuts are the size of raisins, If I was a gangster I would say " the only thing I have in this world are my raisin balls
" no wonder I'm not a rough bad dude just a saint 
scorob777
New member
Thank you, exactly what I was looking for.
casanovaaa
Senior Member
I wouls stick to what the Doc here has to advice you. hope it gets better brother.
Thank you!
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