A possible way to increase SHBG.

Billegitimate

New member
Low SHBG isn't my issue, but I've read many guys on here lament their low SHBG levels and say there's not much they can do.

I just came across this: Dietary isoflavones affect sex hormo... [J Clin Endocrinol Metab. 2000] - PubMed - NCBI

Now, in the past I would have told all people to avoid soy products due to Testosterone lowering effects, and estrogen effects. But, if you're injection your T, then it's not going to hurt it, and what I've now read about phytoestrogens claims that they bind to the estrogen receptors, but don't activate them to the same extent estrogen does!

So perhaps it would be possible to ingest this soy milk (yuck!) and get high plasma concentrations of they soy isoflavones and not have that produce an estrogen issue. Perhaps the isoflavones are binding to the estrogen receptor sites, leaving the excess E in the blood. If that's the case, part of the body's response would be to ramp up SHBG to try to bind the excess. But you wouldn't have the sides of high estrogen because the receptor sites were being occupied yet not fully activated by the isoflavones instead.

Of course, I'm not an expert on these things, nor do I play one on TV. :)

Which reminds me of a quick story. If you came here for the SHBG discussion, you can stop now, or continue and perhaps get a chuckle. I was getting dental work done the other day, and they had a television playing. I don't watch television, but the damn things are hard to turn away from when it's just sitting there in your field of view and your total involvement is just trying to keep your mouth open. Well, suddenly the dentist pulled the tools out of my mouth and asked me if I was okay. I was, and he then said "You just seemed really agitated by something." I pointed to the TV. F'ing Dr. Oz.

So, moral of the story. Dr. Oz is way more annoying than having dental work done.
 
What are you talking about?
Why on earth would someone care to increase their SHBG?
Theres no negative of low SHBG, if you consider an increase in Bio Avail. T a negative effect there is no reason to look for a way to increase SHBG.
 
the only reason i can think of that someone would want to raise shbg is because estrogen binds to it also and people with low shbg are more prone to problems cause by free estrogen in their systems. Either way, i have no idea what this post was about lol.
 
It's funny, while I was researching SHGB I came across a forum dedicated to preventing hair loss. These folks were all about raising SHBG to "mop up excess testosterone" and keeping harmful IGF-1 in check by reducing protein intake :rolleyes:
 
There are many individuals who have very low SHBG, and they appear to be non-responders to TRT. A quick search through the forums will find people talking about their very low SHBG, and how TRT does nothing for their libido, or anything for that matter, even though they have great total and free T. Several have expressed the pattern that very low SHBG sometimes results in someone not feeling as if they're on TRT at all.

Couple of examples:
http://www.steroidology.com/forum/testosterone-replacement-therapy/667137-8-months-trt-no-improvement.html

http://www.steroidology.com/forum/testosterone-replacement-therapy/642613-latest-blood-work-18-months-testosterone-replacement-therapy-trt-no-effect-low-shbg.html

It doesn't seem unreasonable to think that SHBG, like many of our bodily functions, occur at a sweet spot, and that too much or too little has consequences.
 
How low an shbg are u talking about?
If they have very low shbg then they would have pretty decent bio avail t.
 
I've had a TT of 256 ng/dl with 22 SHBG when not on TRT and my bio avail. T was in mid range. Doc told me I'm fine and was leaning away from precribing me TRT. TRT worked for me.
 
Regular administration of androgens lowers SHBG - sometime too low.It can be an issue for trt guys.
So the isoflavones in soy may potentially help.
 
My SHBG has always been low, I'm talking bottom of the range 15(will check units of measurement) which is bottom of the range and usually fluctuates by a few points up or down. TRT has worked for me great... But yes I have heard many reports of guys with low SHBG being non-responders to TRT which makes no sense to me whatsoever so I would liek to know the science behind that. Another thing I noticed is that without turning this into an argument as I am split on this, is that some people report they get nothing out of long-estered test for TRT and only respond to Test Propionate... Strange considering the only difference is the fat solubility of the ester.

It's funny, while I was researching SHGB I came across a forum dedicated to preventing hair loss. These folks were all about raising SHBG to "mop up excess testosterone" and keeping harmful IGF-1 in check by reducing protein intake :rolleyes:

:Pat:
 
Weird. This thread caught me buy surprise cause I am the opposite. My shbg was 48 and E was 128 when I started TRT. I learned quickly that lower SHBG made my libido increase. Well I am sure there are other factors as well. My current protocol keeps shbg around 25 and E around 35 and I feel like I am 18 years old. I am triple that age. I take a pretty aggressive AI protocol. Screw hair, shave your head.
 
Using clomid is one thing but Tamoxifen is not really a safe pharmaceutical. Its directly linked to bladder cancer if u google it on wikipedia. We dont know the long term effects of nolvadex in men.
 
Using clomid is one thing but Tamoxifen is not really a safe pharmaceutical. Its directly linked to bladder cancer if u google it on wikipedia. We dont know the long term effects of nolvadex in men.

Perhaps... but we do know the long-term effects of hypogonadism. It is no way to live life.
 
True. Just saying no one knows squat about its use in TRT let alone have an endo presctibe it as a means to manage SHBG.
 
SHBG modulates the amount of free androgens in the body so the only way to increase it is to also increase estrogen because that's a sign that too much test/andro is available for aromatization.
I think its interesting that Nolva, as a traditional anti-e, has the ability to increase SHBG - probably due to its estrogenic behaviour in the liver (same place that most SHBG production occurs).

Also, thyroid production has a significant impact on SHBG levels - something to be aware of.
 
So what would be the harm in trying nolvadex in addition to anastrozole on TRT? What effects beyond possibly raising SHBG would it have?
My free T ratio is over 6%, so my SHBG level must be in the cellar... but it isn't causing me any problem that I'm aware of. Should I even do anything
 
I would only try this if you are not responding the TRT despite trying everything else AND have low SHBG. So if you are in Newtohrt's situation for example.
 
What grabs my curiosity more is not so much what will raise your SHBG, but why TRT is not as effective for a lot of people with low SHBG (for me, I have low SHBG and it is not a problem)...
 
I have low SHBG and its true - I am pretty much a non-responder to TRT

There are many individuals who have very low SHBG, and they appear to be non-responders to TRT. A quick search through the forums will find people talking about their very low SHBG, and how TRT does nothing for their libido, or anything for that matter, even though they have great total and free T. Several have expressed the pattern that very low SHBG sometimes results in someone not feeling as if they're on TRT at all.

Couple of examples:
http://www.steroidology.com/forum/testosterone-replacement-therapy/667137-8-months-trt-no-improvement.html

http://www.steroidology.com/forum/testosterone-replacement-therapy/642613-latest-blood-work-18-months-testosterone-replacement-therapy-trt-no-effect-low-shbg.html

It doesn't seem unreasonable to think that SHBG, like many of our bodily functions, occur at a sweet spot, and that too much or too little has consequences.

I have been on TRT for 3 years and I have low (below the bottom end of the range) SHBG. TRT gives me a bit more energy, but that is it - I have no libido, still have ED, and I get no help with building muscle or loosing fat or any of the other expected TRT benefits. The sad part is that many doctors do not even know this and they think that the lower the SHBG the better. Trust me, its not.
 
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