I have tried several protocols over the years, but currently my total T is around 1000 and free T is 250 give or take a bit with E2 in the 20s. I tried going a lot lower, with the theory that if you have low SHBG, you need a lower total T and free T to feel good, so for awhile my total T was around 600. The only difference I could feel was that I seemed to have lower energy and got more sore after workouts. In other words, no benefits.
Also, my dad was a non-responder, or more accurately a low responder to just about any drug you can think of and I seem to have inherited that trait. I go to the dentist and they have to give me twice as much Novocaine as expected to have it work. Pain pills of any kind are the same way, as are decongestants and pretty much any drug that was ever prescribed to be for any reason. They all seem to have a very reduced effect on me, to the point where in many cases they don't seem to work at all, at least on normal doses. I have no idea why.