Any research on receptors?
- Thread starter yomama
- Start date
StoneColdNTO
Administrator
That whole receptor down regulation theory is pure BULLSHIT. so all the assumptions you just made are also incorrect.
mostly this "downregulation" is nothing more than SHBG increase due to chronically elevated steroid levels.
The more "constant" the levels of the drug the sooner the plateau comes ie sustanon causes sooner plateaus than suspension and injectables sooner than orals other things being the same (ie same substance).
Regular change of substances helps to avoid this.
The more "constant" the levels of the drug the sooner the plateau comes ie sustanon causes sooner plateaus than suspension and injectables sooner than orals other things being the same (ie same substance).
Regular change of substances helps to avoid this.
magnusson187
New member
Gtrack said:
slin helps too
Steroid receptor regulation by ligands (AAS) isn't really very well understood, and there are conflicting studies based on the time frame of the study, ann whether or not exercise was incorporated into the experiment. Here is a brief excerpt from a piece I wrote on the topic for readers at my home board:
http://www.cuttingedgemuscle.com/Forum/art_showarticle.php?id=8
Q: Often times you hear people talking about taking a break from taking steroids so their receptors can clean out otherwise their gains will come to a halt. Is there any truth to this?
A: Receptors are continually being degraded and remanufactured in cells, so they never really clog up and require cleaning. I think this is a sort of fanciful way of talking about receptor upregulation/downregulation, which is a complex topic. “Do gains slow because receptors downregulate (decrease in number and/or sensitivity) during a cycle?” is probably a more accurate way of posing the question. There are conflicting data in this regard. Short-term in vitro and in vivo studies generally show that androgens upregulate the androgen receptor (AR) in skeletal muscle. For example, in humans given 15 mg of oxandrolone daily for 5 days, the skeletal muscle AR density nearly doubled (13). When exposed to testosterone in vitro, skeletal muscle AR expression increased significantly (14).
In longer-term studies the picture is somewhat different. One study looked at AR expression in androgen treated sedentary rats vs nontreated exercised rats over 8 weeks. The androgen treated rats showed a decrease in the number of receptors, whereas the exercise trained rats showed an increase. (15) Unfortunately, the authors failed to address the question of interest to bodybuilders, and that would be the combined effects of exercise and androgen use on skeletal muscle AR regulation.
In long term studies in humans we get yet a different picture. In work conducted by Sheffield-Moore et. al., (16) older men were supplemented with testosterone so as to bring their testosterone levels into the mid to high physiological range. Androgen receptor expression had more than doubled after one month of treatment, yet by 6 months had returned to baseline. If this downregulation occurs when supraphysiological doses of testosterone are used, it could very well explain why gains tend to slow during a long cycle.
So, unfortunately the data are equivocal. The definitive experiment of combining supraphysiological Anabolic Androgenic Steroids (AAS) with resistance training and looking at AR regulation does not appear to have been carried out yet. Would exercise combined with Anabolic Androgenic Steroids (AAS) maintain increased AR expression, or would the addition of exercise serve to offset the Anabolic Androgenic Steroids (AAS) induced AR downregulation observed in the study by Bricout et al? Do the extremely high doses of Anabolic Androgenic Steroids (AAS) used by bodybuilders lead to more or less downregulation ( or even upregulation ) compared to what was seen by Sheffield-Moore et al? These are just a couple of questions that require further research, and could lead to answers on why exercise combined with Anabolic Androgenic Steroids (AAS) use is so much more productive than simply using steroids alone when it comes to building muscle mass.
http://www.cuttingedgemuscle.com/Forum/art_showarticle.php?id=8
Q: Often times you hear people talking about taking a break from taking steroids so their receptors can clean out otherwise their gains will come to a halt. Is there any truth to this?
A: Receptors are continually being degraded and remanufactured in cells, so they never really clog up and require cleaning. I think this is a sort of fanciful way of talking about receptor upregulation/downregulation, which is a complex topic. “Do gains slow because receptors downregulate (decrease in number and/or sensitivity) during a cycle?” is probably a more accurate way of posing the question. There are conflicting data in this regard. Short-term in vitro and in vivo studies generally show that androgens upregulate the androgen receptor (AR) in skeletal muscle. For example, in humans given 15 mg of oxandrolone daily for 5 days, the skeletal muscle AR density nearly doubled (13). When exposed to testosterone in vitro, skeletal muscle AR expression increased significantly (14).
In longer-term studies the picture is somewhat different. One study looked at AR expression in androgen treated sedentary rats vs nontreated exercised rats over 8 weeks. The androgen treated rats showed a decrease in the number of receptors, whereas the exercise trained rats showed an increase. (15) Unfortunately, the authors failed to address the question of interest to bodybuilders, and that would be the combined effects of exercise and androgen use on skeletal muscle AR regulation.
In long term studies in humans we get yet a different picture. In work conducted by Sheffield-Moore et. al., (16) older men were supplemented with testosterone so as to bring their testosterone levels into the mid to high physiological range. Androgen receptor expression had more than doubled after one month of treatment, yet by 6 months had returned to baseline. If this downregulation occurs when supraphysiological doses of testosterone are used, it could very well explain why gains tend to slow during a long cycle.
So, unfortunately the data are equivocal. The definitive experiment of combining supraphysiological Anabolic Androgenic Steroids (AAS) with resistance training and looking at AR regulation does not appear to have been carried out yet. Would exercise combined with Anabolic Androgenic Steroids (AAS) maintain increased AR expression, or would the addition of exercise serve to offset the Anabolic Androgenic Steroids (AAS) induced AR downregulation observed in the study by Bricout et al? Do the extremely high doses of Anabolic Androgenic Steroids (AAS) used by bodybuilders lead to more or less downregulation ( or even upregulation ) compared to what was seen by Sheffield-Moore et al? These are just a couple of questions that require further research, and could lead to answers on why exercise combined with Anabolic Androgenic Steroids (AAS) use is so much more productive than simply using steroids alone when it comes to building muscle mass.
simpllyhuge
New member
its would be neato if they could come out with supper conndensed quality calorie mrp's or pills so you could hit 7000 caolories a day easy.
bleachcola
New member
OMEGA said:on a side note:
NANDI is a genius, and nice person
Agreed. This man and the staff at CEM taught me everything I know. It's okay that he's a smoker too
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