according to this it wouldn't make a difference:
Absorption
Supplements need to be absorbed to be effective. Minerals can be chelated with amino acids to significantly increase absorption, but this expensive process is commonly avoided by most brands. If a tablet does not dissolve properly, it can upset your stomach and its nutrients will not be absorbed. Most supplements are densely compressed, up to 350 psi (pounds per square inch) in order to get as many ingredients as possible into one tablet. Unfortunately, your stomach cannot dissolve these highly compressed tablets entirely, so a majority of most supplements are excreted, depriving you of the promised nutritional benefits.