There's no set age when one would HAVE to come off. I do however think there will be a point in time where running large cycles with multiple compounds might be too much for the body to handle, but that is going to vary from one individual to the next. There are actually a ton of benefits from steroid usage especially when one starts to get a bit older and test levels start to naturally decline. A friend of mines father is in his 60s, he runs GH and is on TRT, and I have never seen a more healthy looking, fit, positive, older man in my life, the guy looks ten year younger than he actually is and is in fantastic shape. Its a personally choice in the end though, as is everything else in life.