mass rookie
New member
whats the difference in taking tab form or injecting it ? is it good for increasing your appetite,could you take while on a cycle to bulk up ?
b-12 whats it good for
- Thread starter mass rookie
- Start date
StoneColdNTO
Administrator
pullinbig said:
We all might want to re-think that..........
Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study.
Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T.
Department of Internal Medicine, Division of Hematology, Adnan Menderes University Medical School, Aydin, Turkey. zahitb@yahoo.com
BACKGROUND: Cobalamin (vitamin B12) deficiency, the most common cause of megaloblastic anemia, is treated with intramuscular (IM) cobalamin. It has been suggested by some investigators that oral (p.o.) cobalamin treatment may be as effective in the treatment of this condition, with the advantages of ease of administration and lower cost. OBJECTIVE: This study assessed the effects and cost of p.o. versus i.m. cobalamin treatment in patients with megaloblastic anemia due to cobalamin deficiency. METHODS: This was a 90-day, prospective, randomized, open-label study conducted at the Division of Hematology, Department of Internal Medicine, Adnan Menderes University Research and Practice Hospital (Aydin, Turkey). Patients aged > or =16 years with megaloblastic anemia due to cobalamin deficiency were randomized to receive 1000-microg cobalamin p.o. once daily for 10 days (p.o. group) or 1000-microg cobalamin i.m. once daily for 10 days (i.m. group). After 10 days, both treatments were administered once a week for 4 weeks, and after that, once a month for life. Patients were assessed for the presence of reticulocytosis between treatment days 5 and 10 until it was detected. Therapeutic effectiveness was assessed by measuring hematologic parameters on days 0, 10, 30, and 90 and serum vitamin B12 concentration on days 0 and 90. The Mini-Mental State Examination was used before and after the B12 therapy for cognitive function assessment and 125-Hz diapozone was used for vibration threshold testing. Neurologic sensory assessment, including soft-touch and pinprick examinations, was used to identify neuropathy at baseline and study end. Tolerability was assessed using laboratory tests and patient interview. Cost was assessed using the cost of the study drug and of the injection. RESULTS: Sixty patients completed the study 26 in the p.o. group (16 men, 10 women; mean [SD] age, 60 [15] years) and 34 in the i.m. group (17 men, 17 women; mean [SD] age, 64 [10] years). Reticulocytosis was observed in all patients. In the p.o. group, at days 30 and 90, all hematologic parameters changed significantly versus day 0 (mean hemoglobin levels increased [both P<0.001]; mean corpuscular volume decreased [both P<0.001]; mean white blood cell count increased [day 30, P<0.01; day 90, P<0.001]; and mean platelet count increased [both P<0.001]). The mean serum vitamin B12 concentration increased significantly from day 0 to 90 (P<0.001). These hematologic parameters and the recovery patterns were similar between the 2 groups. Neurologic findings included sensitive peripheral neuropathy in 9 patients (15.0%), alteration of cognitive function (loss of memory, impaired concentration) in 7 patients (11.7%), and loss of sense of vibration in 5 patients (8.3%). Neurologic improvement was detected in 7 of 9 patients (77.8%) in the p.o. group and 9 of 12 patients (75.0%) in the i.m. group at day 30. CONCLUSIONS: In this study of patients with megaloblastic anemia due to cobalamin deficiency, p.o. cobalamin treatment was as effective as i.m. cobalamin treatment. P.o. treatment also was better tolerated and less expensive compared with IM treatment. However, because of the small sample size and the short term of this study, further long-term studies are needed to determine the efficacy of p.o. cobalamin treatment.
"It has been suggested by some investigators that oral (p.o.) cobalamin treatment may be as effective in the treatment of this condition, with the advantages of ease of administration and lower cost".
as soon I read this sentence it was over for this study. when was this study conducted? i can get sterile b12 50ml 2mg/ml for 60 bucks. at 1mg/d thats .6 cents a day. cheap enough.
in order for B12 to be effective as a pharmacological agent high serum concentrtations must be obtained and this is just not possible orally.
there are many different types of anemia. the one listed her is most commonly caused by a b12 deficiancy in the diet. very simple to treat. b12 is used for many body functions ranging from insulin reguation to emotional well being. many of these conditions are far more severe than anmeia and require IM administration get blood serum levels up.
the reason some folks become deffient is because they cannot absorb b12 in the normal manner. absorbtion is a complex process and if one thing is out of whack a deficency occurs. it takes years for this to maifest because of the bodys ability to reabsorb b12 from bile. very little b12 is lost thru urination, most water soluable vitamins are pass this way. this is where b12 differs from other water soluable vitamins.
now this is not to say that oral adminstration does not have its place but it is more effective if taken IM. b12 is used for a wide range of treating a variety of ailments. this study focused on one. big deal and they didnt have the gonads to say "it definately was as effective". Hmmmm....... anyway if you wana take b12 orally and miss out on a big part of the benefits by all means have at it. kinda like taken methyl test (not m1t) orally when you could be doin cyp IM and gettin great results.
i'd be glad to pull up the studies if you like but we all have pc's here so search away guys.
as soon I read this sentence it was over for this study. when was this study conducted? i can get sterile b12 50ml 2mg/ml for 60 bucks. at 1mg/d thats .6 cents a day. cheap enough.
in order for B12 to be effective as a pharmacological agent high serum concentrtations must be obtained and this is just not possible orally.
there are many different types of anemia. the one listed her is most commonly caused by a b12 deficiancy in the diet. very simple to treat. b12 is used for many body functions ranging from insulin reguation to emotional well being. many of these conditions are far more severe than anmeia and require IM administration get blood serum levels up.
the reason some folks become deffient is because they cannot absorb b12 in the normal manner. absorbtion is a complex process and if one thing is out of whack a deficency occurs. it takes years for this to maifest because of the bodys ability to reabsorb b12 from bile. very little b12 is lost thru urination, most water soluable vitamins are pass this way. this is where b12 differs from other water soluable vitamins.
now this is not to say that oral adminstration does not have its place but it is more effective if taken IM. b12 is used for a wide range of treating a variety of ailments. this study focused on one. big deal and they didnt have the gonads to say "it definately was as effective". Hmmmm....... anyway if you wana take b12 orally and miss out on a big part of the benefits by all means have at it. kinda like taken methyl test (not m1t) orally when you could be doin cyp IM and gettin great results.
i'd be glad to pull up the studies if you like but we all have pc's here so search away guys.
Last edited:
StoneColdNTO
Administrator
pullinbig said:
Looks like when I copied this from a post by Ulter, I forgot a line........
Clin Ther. 2003 Dec;25(12):3124-34.
Frosty said:
it is........brain fart. i'll use my mulligan on that one if i may. b12 differs from all other water soluable vits as it is not passed thru urination (well just a trace) it is excreted in the bile and reabsorbed. sounds nasty but true. very odd but beneficial vitamin.
Last edited:
