ive been taking v12 in the morning and pre workout. Honestly from what I hear, and just from personal experience i like it this way, because it gives a rush of ATP which as you know is the energy provided for anabolism and catabolism as well as muscle contraction(as well as calcium, that is one reason while calcium is so important). Also it seems very important to drink enough water that way it can break down the large molecules in the creatine and convert them into more ATP. If you have ever noticed while taking creatine that whenever you go from not drinking much water in the day to drinking a shitload you always get a mad energy rush, even if it is 2-3 hours after you dose yourself. It may just be because the creatine in v12 is of a different chemical structure than just plain creatine monohydrate, but I get the best results drinking it about 45 min before workout. There is a lot of talk however about saturation, and how after taking creatine for 3 weeks it is not as necessary to take it 7 days a week maybe more like 5, but I figure why even take the chance.