<h1>DIGIBIND</h1><p> DIGIBIND, Digoxin Immune Fab (Ovine), is a sterile lyophilized powder of antigen binding
fragments (Fab) derived from specific antidigoxin antibodies raised in sheep. Production of
antibodies specific for digoxin involves conjugation of digoxin as a hapten to human albumin.
Sheep are immunized with this material to produce antibodies specific for the antigenic
determinants of the digoxin molecule. The antibody is then papain-digested and digoxin-specific
Fab fragments of the antibody are isolated and purified by affinity chromatography. These
antibody fragments have a molecular weight of approximately 46,200.
Each vial, which will bind approximately 0.5 mg of digoxin (or digitoxin), contains 38 mg of
digoxin-specific Fab fragments derived from sheep plus 75 mg of sorbitol as a stabilizer and
28 mg of sodium chloride. The vial contains no preservatives.
DIGIBIND is administered by intravenous injection after reconstitution with Sterile Water for
Injection (4 mL per vial).</p>
fragments (Fab) derived from specific antidigoxin antibodies raised in sheep. Production of
antibodies specific for digoxin involves conjugation of digoxin as a hapten to human albumin.
Sheep are immunized with this material to produce antibodies specific for the antigenic
determinants of the digoxin molecule. The antibody is then papain-digested and digoxin-specific
Fab fragments of the antibody are isolated and purified by affinity chromatography. These
antibody fragments have a molecular weight of approximately 46,200.
Each vial, which will bind approximately 0.5 mg of digoxin (or digitoxin), contains 38 mg of
digoxin-specific Fab fragments derived from sheep plus 75 mg of sorbitol as a stabilizer and
28 mg of sodium chloride. The vial contains no preservatives.
DIGIBIND is administered by intravenous injection after reconstitution with Sterile Water for
Injection (4 mL per vial).</p>
