Unless you are at your genetic limit, then no. However it will effect you mentally. You don't feel you are getting the most out of your training/dieting when you are off which can lead some people to make poor decisions when using steroids. Usually resulting in bad side effects.
I also gained 120 lb natty. The experience of putting on the weight yourself will give you a good foundation for diet and training, and make you appreciate what steroids can really do for you.
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