Pupil2Prodigy
Onologylearning
Alcohol exacerbates liver stress during oral cycles, but what else should be avoided with aas use of all kinds?
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Factors to Avoid While Cycling?
- Thread starter Pupil2Prodigy
- Start date
In Brief: Tamoxifen and SSRI Interactions
Use of a selective serotonin reuptake inhibitor (SSRI) is common in women taking tamoxifen (Nolvadex, and others) for breast cancer, both to treat depression and to decrease hot flashes. However, tamoxifen must be metabolized by CYP2D6 to become pharmacologically fully active (MJ Higgins et al. J Natl Compr Canc Netw 2009; 7:203), and the SSRIs fluoxetine (Prozac, and others) and paroxetine (Paxil, and others) are strong inhibitors of CYP2D6. Sertraline (Zoloft, and others) inhibits CYP2D6 to a lesser extent. Citalopram (Celexa, and others) and escitalopram (Lexapro), the 2 other SSRIs approved for treatment of depression, are only weak inhibitors of CYP2D6.
Two observational studies presented at a recent meeting of the American Society of Clinical Oncology (45th annual meeting, May 29-June 2, 2009, Orlando, FL abstracts CRA508, CRA509) examined the effect of strong inhibitors of CYP2D6 on the success rate of tamoxifen in preventing recurrence of breast cancer. One found that women who took fluoxetine, paroxetine or sertraline (or bupropion, duloxetine, terbinafine, quinidine or long-term diphenhydramine) with tamoxifen had a higher 2-year recurrence rate (13.9% vs. 7.5%). The other study found no association between cancer recurrence and use of a CYP2D6 inhibitor.
There is no good evidence that any one SSRI is more effective than any other for treatment of depression. For women who are taking tamoxifen and need to begin treatment with an SSRI to treat depression, citalopram or escitalopram might be the safest choice (Treat Guidel Med Lett 2006; 4:35). Use of an SSRI to treat hot flashes in women taking tamoxifen should probably be reconsidered.
In Brief: Tamoxifen and SSRI Interactions | The Medical Letter, Inc.
Not really an interaction with AAS, but since a great deal of AAS users use nolva for post cycle therapy (pct) I figured its worth mentioning.
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Pupil2Prodigy
Onologylearning
There probably are a good deal more that we're unaware of which I'm sure other, more knowledgeable posters can share with us. My cousin, who knows I just started my cycle, is a pharmacist and has given me a few things to watch out for for possible interactions.
Here's another one, anti-coagulation and anti-diabetic medicines and AAS directly:
Abstract
Drug-drug interactions, or interference between drugs and other treatments, depend on many factors and are therefore difficult to predict. However, a number are clearly established in the case of anabolic-androgenic steroids. The beneficial interactions between anabolic steroids and radiotherapy or cytostatic drugs respectively are of therapeutic value. Adjuvant treatment with anabolic compounds in patients undergoing radiation and/or cytostatic therapy is beneficial because it can prevent or reduce depression of erythropoiesis, granulopoiesis and thrombopoiesis. It also diminishes protein catabolism, supports recovery, improves the general condition of the patient and minimizes radiation sickness. Potentially adverse interactions with anabolic steroids must be expected in the case of oral anticoagulants and antidiabetic drugs, since sensitivity to each of the latter is increased. This makes it particularly advisable to monitor patients receiving either oral anticoagulants or antidiabetic treatment concurrently with anabolic drugs.
Interactions of anabolic steroids. [Wien Med Wochenschr. 1993] - PubMed - NCBI
he's warned me about smoking and either clomid or anastrozole, forgot which one for sure. I'll read up and try to post another study if I find something.
Pupil2Prodigy
Onologylearning
keep me posted thanks
Methodology
I am banned!
Haha, creatine, my body can't really handle it on its own, let alone on cycle, even excess vitamins can do a number on your liver. Nitric oxide isn't recommended, as it can greatly increase your blood pressure, but it doesn't mean you can't use it, I would just stay away from 1MR/Jack3d, like the really powerful stuff, or the ones that have like 100 ingredients that don't need to be in there. I take Optimum Nutrition AmiN.O. Energy, all it is, is BCAAs and caffeine, no "extreme" vasodilators or excessive unknown caffeine content or caffeine alternatives. And you definitely have to stay away from vaginas, those things will literally suck the testosterone out of your body.
Pupil2Prodigy
Onologylearning
all good information lols
I have a horrible addiction to caffeine, I should drop it for aas?
soldier74
avi changes as i do
Hmm...can't agree w/ ya on staying away from pussy bro. More like can't get enough!
No problem brother. I've read that certain cycles or AAS can increase BP dramatically and caffeine use also temporarily raises BP so that's something to watch out for. Keep a very close eye on your blood pressure and have it checked regularly if you're taking as much caffeine as you make it sound like.
soldier74
avi changes as i do
STRESS. Keep coffee consumption to 2 or less cups a day.
Pupil2Prodigy
Onologylearning
I'm seriously addicted, I drink a 2 liter of mountain dew everyday lol
324mg/Day
Pupil2Prodigy
Onologylearning
3 days off and my energy level returns to normal lol, I'll have to make it happen
I'm not saying you have to cut it out completely, just monitor your consumption and adjust accordingly. Start off by having your BP checked. See if its even high to begin with as some ppl tolerate caffeine better than other (don't know the physiological reason for it unfortunately). But I have an aunt who can drink a half cup of coffee or half a soda and she feels like she's having an anxiety attack or nervous breakdown from her BP skyrocketing. Another aunt and my brother and sister drink AT LEAST 5 cups of coffee a day and their BP is completely normal. We need to pay greater attention to it since AAS use, and ancillaries, can raise our BP. I know either JM750 or 49er have a thread going in right now about BP, a few ideas were tossed around to lower it naturally, may not be a bad idea to check that thread out if you got the time
Pupil2Prodigy
Onologylearning
Hell I didn't know that, a lot of compounding factors aye?
Sworder
New member
In the early breast cancer clinical trial, the most common side effects seen with ARIMIDEX include hot flashes, joint symptoms (including arthritis and arthralgia), weakness, mood changes, pain, back pain, sore throat, nausea and vomiting, rash, depression, high blood pressure, osteoporosis, fractures, swelling of arms/legs, insomnia, and headache
^^^^ right from the Arimidex website. My point is every chemical we put in our bodies, has some sort of antagonist or protagonist effect on the body, a ying to the yang if you will. Since we're exogenously raising our test levels among other things and using medications and research chemicals, we all should do proper research, bloodwork, check ups, etc to make sure we're not doing more harm than good and that we can live with the results of our choices. We're using these things to better ourselves physically and mentally in the gym and life in general often times without truly understanding what else they're doing to our body behind the scenes. I've come to love this forum for the most part, minus the trolls of course, and have learned a lot from many members. I'd hate to hear a horror story from anyone on here bc they didn't have the proper information to make an informed decision. We are a community and we should look after each other as such!
hardtarget
Pumpin Up!!
Don't eat junk food while cycling. Make sure you eat healthy food that will keep you anabolic.
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