Fatigue/depression/low Libido And Pseudo Gyno - Full Blood Panel Inside [25 Y/o Male]


New member
Hi, I'm a 25 year old male and I've been having issues with fatigue, libido and general depression/anxiety for the last few months. My background is fully natural up to November 2017 when I quit competing in drug tested powerlifting, so I thought I'd try a low dose aromasin/exemestane by itself for physique improvements (I was using 3.125mg ED for one month and then bumped it to 6.25mg ED for another month). I realized my stupidity in using an AI on its own without prior use of hormones/steroids so I stopped (and I was also getting side effects such as poor sleep and fatigue, basically everything associated with crashed estrogen). I did look good visually but that was only due to the transient water shedding.

I felt really good prior to taking aromasin like an idiot. My blood work before taking anything (exemestane is the only hormonal thing I have ever taken and it was for two months at the above dose) was:

Total Testosterone: 28.9 nmol/L [ref 8-29]

Estradiol: 99 pmol/L [ref 0-160]

TSH: 1.4 mIU/L [ref 0.2-4]

Free T3: 4.1 pmol/L [ref 3.5-6.5]

My blood work from last week (3 months after full cessation of aromasin/anything hormonal):

Total Testosterone: 32.8 nmol/L [ref 8-29]

Free Testosterone: 573 pmol/L [ref 175-700]

Estradiol: 80 pmol/L [0-160]

Prolactin: 8 ug/L ref [0-15]

SHBG: 54 nmol/L [ref 10-55]

FSH: 4 IU/L [ref 1-18]

LH: 8 IU/L [ref 1-9]

Albumin: 42 g/L [ref 33-48]

IGF-1: 203 ug/L [ref 105-316]

eGFR: 65 mL/min/1.7 [ref >=60]

TSH: 0.12 mIU/L [ref 0.2-4]

Free T3: 4.7 pmol/L [ ref 3.5-6.5]

Free T4: 16.6 pmol/L [ref 10.0-25.0]

Creatinine: 131 umol/L [ref 50-120]

1. I've bolded what I think might be an issue. All other basic blood work came back fine. I am suspecting that my bout of aromasin will take longer for my HPG/HPA/HPT axes to recover (not to mention time for my poor aromatase enzyme to regenerate itself), but it looks like I have low total E2 for my age and possibly low free E2? Since my total E2 is low-moderate and my SHBG is high, in theory my free E2 would be really low right according to this statement:
"High SHBG Men (not on HRT): High SHBG will naturally push down free estradiol levels. So a man with low medium estradiol could end up with overly low free estradiol levels due to so much of his estradiol pool being bound up."

2. Do you see any other possible issues? I also think that my prolactin could benefit from being lowered a tad so I would like to give cabergoline a try. I have legit Dostinex on its way, I'm thinking of trying it at 0.125mg twice a week to start and see how it goes. I've used mucuna pruriens (from Inhibit P, contains 180mg l-dopa) and based on that I feel like I'd benefit from a dopamine agonist at very low - low doses for off-label depression treatment. I also realize that my I'm borderline hyperthyroid based on my TSH but my free T4/T3 are in range so my endo wasn't concerned but he did reduce my dosage of thyroid meds to 100mcg levothyroxine + 10mcg lioothyronine.

3. Also, I seem to have perpetual pseudo gyno in that I have fatty tissue/a visually large amount of fat in my chest despite having my E2 and prolactin in check. Would a SERM help at all or cause more damage than worth?

4.One last thing, I wasn't able to get my DHT or DHEA-S measured for some reason. Do you think taking a T boosting supplement like cordyceps and shilajit would be beneficial in bringing my e2 back up?

Thank you for your generous time!
It takes time for estrogen to come back. Not only did you fuck up on taking that ai you took 3 time what you should. Try letrozole next time it is very good for what you were taking it for with out the complete shut down. FSH is low and that is the root of the problem with your estrogen. The creatinie is a problem too. Hcg may help get you going again.
I don't understand the issues here, or the advice. Most people would kill for bloodwork like that. Your test is super high. LH is high even in the high test environment. SHBG is high too, but that should probably be expected with test above the normal range. Estrogen is smack in the middle of the range, as is prolactin. Thyroid looks fine.

So, other than the creatinine I don't see a problem - and the creatinine is probably just eating too much protein or protein like supps.

DPR why do you think aromasin at 3mg /day is 3x too much? I wouldn't take it just on its own, but that doesn't seem like a high dose. And why would letro be better in this situation?

What does FSH have to do with estrogen?

How would HCG help if testosterone is already high and outside of normal range?

I'm not trying to be argumentative, just trying to learn. I'm clueless on those things.