Ineffectiveness of human chorionic gonadotropin in weight reduction: a double-blind study.
Stein MR, Julis RE, Peck CC, Hinshaw W, Sawicki JE, Deller JJ Jr.
Our investigation was designed to retest the hypothesis of the efficacy of human chorionic gonadotropin (HCG) on weight reduction in obese women in a clinic setting. We sought to duplicate the Asher-Harper study (1973) which had found that the combination of 500 cal diet and Human Chorionic Gonadotropin (HCG) had a statistically significant benefit over the diet and placebo combination as evidenced by greater weight loss and decrease in hunger. Fifty-one women between the ages of 18 and 60 participated in our 32-day prospective, randomized, double-blind comparison of Human Chorionic Gonadotropin (HCG) versus placebo. Each patient was given the same diet (the one prescribed in the Asher-Harper study), was weighed daily Monday through Saturday and was counselled by one of the investigators who administered the injections. Laboratory studies were performed at the time of initial physical examinations and at the end of the study. Twenty of 25 in the Human Chorionic Gonadotropin (HCG) and 21 of 26 patients in the placebo groups completed 28 injections. There was no statistically significant difference in the means of the two groups in number of injections received, weight loss, percent of weight loss, hip and waist circumference, weight loss per injections, or in hunger ratings. Human Chorionic Gonadotropin (HCG) does not appear to enhance the effectiveness of a rigidly imposed regimen for weight reduction.
PMID: 786001 [PubMed - indexed for MEDLINE]
Human Chorionic Gonadotropin (HCG) Treatment of Obesity
Kaup R. Shetty, MD; Ronald K. Kalkhoff, MD
Arch Intern Med. 1977;137(2):151-155.
Abstract
After a nine-day control period, six hospitalized obese women were placed on 500 calorie diets and were given 125 IU of human chorionic gonadotropin (HCG) intramuscularly daily for 30 days. Another five obese women received injections of diluent only and consumed identical diets for the same period. Mean weight loss in the HCG-treated group was nearly identical to that achieved by women given the placebo. Reduction of triceps skinfold thickness or circumferential body measurements of the chest, waist, hips, and thighs were not different. Patterns of change of a variety of plasma and urine substrates, electrolytes, and hormones were similar in the two groups and consistent with semistarvation and weight loss. These results indicate that Human Chorionic Gonadotropin (HCG) has no effects on chemical and hormonal parameters measured and offers no advantage over calorie restriction in promoting weight loss.
(Arch Intern Med 137:151-155, 1977)
The effect of human chorionic gonadotropin (HCG) in the treatment of obesity by means of the Simeons therapy: a criteria-based meta-analysis.
Lijesen GK, Theeuwen I, Assendelft WJ, Van Der Wal G.
Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands.
1. A meta-analysis was conducted to assess if there is scientific ground for the use of human chorionic gonadotropin (HCG) as adjunctive therapy in the treatment of obesity. 2. Published papers relating to eight controlled and 16 uncontrolled trials that measured the effect of Human Chorionic Gonadotropin (HCG) in the treatment of obesity were traced by computer-aided search and citation tracking. 3. The trials were scored for the quality of the methods (based on four main categories: study population, interventions, measurement of effect, and data presentation and analysis) and the main conclusion of author(s) with regard to weight-loss, fat-redistribution, hunger, and feeling of well-being. 4. Methodological scores ranged from 16 to 73 points (maximum score 100), suggesting that most studies were of poor methodological quality. Of the 12 studies scoring 50 or more points, one reported that Human Chorionic Gonadotropin (HCG) was a useful adjunct. The studies scoring 50 or more points were all controlled. 5. We conclude that there is no scientific evidence that Human Chorionic Gonadotropin (HCG) is effective in the treatment of obesity; it does not bring about weight-loss of fat-redistribution, nor does it reduce hunger or induce a feeling of well-being.
Publication Types:
Meta-Analysis
PMID: 8527285 [PubMed - indexed for MEDLINE]
PMCID: PMC1365103
Chorionic gonadotropin in weight control. A double-blind crossover study.
Young RL, Fuchs RJ, Woltjen MJ.
Two hundred two patients participated in a double-blind random cross-over study of the effectiveness of human chorionic gonadotropin (HCG) vs placebo in a wieght reduction program. Serial measurements were made of weight, skin-fold thickness, dropout rates, reasons for dropping out, and patient subjective response. There was no statistically significant difference between those receiving Human Chorionic Gonadotropin (HCG) vs placebo during any phase of this study (P greater than .1).
PMID: 792477 [PubMed - indexed for MEDLINE]
__________________