For myself down regulation of thyroid only starts when I get above 6iu doses, bu thats why you run t4 with your GH to normalize the down regulation. Taking it EOD or 3xweek is fine if your bulking as it is meant to be ran at same IU per week split into 3 doses which in turn will yield a higher down regulation of thyroid as well as insulin sensitivity issues. Hence the running of T4 and insulin to accommodate this. You will also hold alot more water compared to running lower doses over 7 days.
For the average GH user they would benefit a lot more from 4iu per day 7 days a week and even 5 on 2 off if money is an issue.
Here are some protocols by Gavin Kane, what you are talking about is protocol 3
First recommended use is for people looking for overall health, boosted immune system, fat loss, and general sense of well being. You will also notice small increases in lean muscle mass, as well as healthier skin, hair, etc. For people looking to use hGH for this reason, I recommend 2iu per day take first thing in the morning for no less than 6 month cycles, preferably full time use. You will not need to worry about insulin insensitivity issues or down-regulation of your thyroid.
Second recommended use is for people looking to lose the maximum amount of fat while gaining the most lean mass possible. This type of cycle is great for endomorphs or anyone who generally has a hard time staying lean while bulking. For this type of use, I recommend 4-6iu per day, ½ taken in the morning 30 minutes before breakfast, and the other half dose taken immediately post workout.
The third recommend use of hGH is for athletes off season looking to gain the maximum amount of mass possible. You will gain a lot of lean mass, but also have a lot of water retention due to the dosing schedule. For this type of growth hormone cycle, you will take your weekly hGH dose and split it into three shots taken post workout. For example, a bodybuilder who normally does 4iu per day on a normal schedule, which is 28iu per week, you will take 10iu 3x per week post workout only. When using hGH in this manner you may experience increased insulin sensitivity and it is highly recommended you use exogenous insulin with your hGH. This timing schedule forces the maximum conversion to IGF-1 in the muscle as well as generates hyperplasia. You will have amazing recovery abilities, quick increases in lean mass and can cycle the use on and off in conjunction with your steroid cycles.
The fourth and final method of hGH is for competitors looking to lose the maximum amount of fat, or for any athlete looking to lean up. For this type of use, I recommend taking 4-6iu first thing in the morning on an empty stomach, about ½ hour before doing a morning session of cardio, or before your first morning meal. You will create an optimal environment for burning fat all day long. You will want to use t3/t4 in conjunction with this cycle to further aid in fat loss, as well as the down-regulation of thyroid output.