One last question...
Why should my goal be to not take any Aromatase inhibitor (AI) at all?
Just curious about the reasons behind that thinking...
I took this for the other thread posted by Cashout.
First, I am a big believer in not using an Aromatase inhibitor (AI) if that is at all possible while on HRT.
With that said, it requires a little differnt approach to HRT than what I've seen around here over the past few years. That may be a function of the people designing the protocols. Regardless, I know non-AI HRT can be tricky but it can be done and I fiddled around with it for a while when I was on HRT so I know it takes some doing.
I am very estrogen sensitive. So it was a big step for me to move off of an Aromatase inhibitor (AI) while I was on HRT.
So here is what I learned and why I suggest not using an Aromatase inhibitor (AI) if you can avoid it.
First, Aromatase inhibitor (AI) use over long term, which HRT is, will skew lipid profiles. That is not good for us guys in the 40+ crowd. That increases our risk for cardiovascular issues.
Next, they seem to have an impact on connective tissue and joints. I have talked with many of you who have expressed issues with joints and convective tissue after significant time using AIs. I, myself, experienced the very same things and I've never had connective tissue or joint problems in my life. After 5 months of using an Aromatase inhibitor (AI) I did.
Lastly, long term Aromatase inhibitor (AI) use also contributes to a reduction in naturally produced GH. There is research that indicates that to be plausible and I experienced it first had as have some of you all.
So, what do we do to avoid using an AI?
Well, I think the most important thing to do is taper your test dosages up very very slowly and monitor the blood changes including estrogen.
I, like a lot of guys on here, started my HRT with a 200 mg per week of test cyp dosage. Many of you guys are 200 mgs every 5 days.
What starts to happen on these type of dosage is we see significant peeks in total test in the 30-48 after injections that are well beyond normal physiological ranges. It would happened to me. I take my weekly 200 mg shot and BANG my levels would rocket up to 2000+ ng/dl and fall back to 1000 ng/dl over the course of the week. By drawing my blood work throughout the week and watching it, my estrogen would spike shortly after my test peeked and it too would drop back down to over the course of the week until my next weekly injection. So, being estrogen sensitive, I started to have issues. I assumed like many of us, "Hey, I need an AI!" So, I got on one and things got better. Sure after 5 months my joints were starting to hurt and my lipids were shifting but my estrogen was staying near 20 so I was all good.
Then I started to think. If I eliminate the test peeks that were cause the estrogen issues, I could quite the Aromatase inhibitor (AI) and my joints might feel better. So, I started injecting smaller dosages more frequently. First on a 2 day a week schedule, then on a 3 day a week schedule. Guess what? It worked. My total test number peeks got smoother and smoother and my estrogen started to drop into the low single digits so I started to taper out the Aromatase inhibitor (AI) altogether. As i did that my estrogen returned to a comfortable level of 24 and and it stayed fairly stable there even though I was still using 200 mgs over the course of 7 days. I eliminated the peeks and the problem.
So, what took me months and months of trial and error to fix could have been handled on the front end if I had spread my injections out over multiple smaller applications during the week.
Of course, 3-4 injects during the week could actually present significant pains in the butt - really. So, that is why I switched to pinning with insulin needles. If I needed to, I could pin 25 mg of test cyp every day with an insulin pin and never have any discomfort at all.
So, there is my 2 cents on AIs. For long term HRT guys, I think we should work toward the goal of not using an Aromatase inhibitor (AI) if at all possible. I've mentioned how I worked toward that objective.
I know some will always need Aromatase inhibitor (AI) and that is fine, but I'd suggest try to go without or as little as possible. No need to put another drug in the body when some proper protocol management techniques can eliminate the need for it.