GAKIC INDEPENDENT STUDY
High-intensity dynamic human muscle performance enhanced by a metabolic intervention (top)
STEVENS, B. R., M. D. GODFREY, T. W. KAMINSKI, and R. W. BRAITH
Med. Sci. Sports Exerc., Vol. 32, No. 12, 2000, pp. 2102-2108
Purpose
The purpose of this study was to quantify the effects of a metabolic treatment on human muscle dynamic performance (strength, work, and fatigue) measured under conditions of acute, exhaustive high-intensity anaerobic isokinetic exercise.
Methods
Unilateral prefatigue and postfatigue peak torque and work values were measured in the quadriceps femoris of 13 subjects using a computer-controlled isokinetic dynamometer, over a 23-d interval. The two experimental treatments were: 1) a glycine and L-arginine salt of [alpha]-ketoisocaproic acid calcium ("GAKIC"); and 2) isocaloric sucrose (control). Based on a randomized double-blind cross-over repeated measures design, measurements were made before and during an exhaustive anaerobic fatigue protocol to calculate a F atigue R esistance I ndex (FRI = [peri-exhaustion torque] / [baseline peak torque]), as well as total work.
Results
The FRI and total work for each of the exhaustion sets measured at 0, 5, and 15 min after oral GAKIC treatment were greater than values obtained for isocaloric control treatment (P < 0.02). GAKIC treatment increased the mean resistance to fatigue (FRI) up to 28% over isocaloric control. Overall gain in total muscle work attributable to GAKIC was 10.5 +/- 0.8% greater than control, sustained for at least 15 min. After 24 h, both GAKIC and control concentric forces returned to the same absolute values (P > 0.05): mean FRI = 0.42 +/- 0.05 and mean total work = 4600 +/- 280 J. There were no significant differences attributable to random order of testing.
Conclusions
Compared with isocaloric carbohydrate, oral GAKIC treatment increased muscle torque and work sustained during intense acute anaerobic dynamic exercise; additionally, it increased overall muscle performance by delaying muscle fatigue during the early phases of anaerobic dynamic exercise.
Interpretations by ZAP
The interesting part to me as an exercise scientist was that it is possible to reduce metabolic acidosis, ammonia levels, not to mention a host of other metabolic and enzymatic pathways and have that show a noticeable effect on muscle torque and delays in fatigue. The real important part was the possible use of this science to affect performance in sports. Think of how important this can be for a sporting event such a 200 M dash in track and field. By delaying that fatigue that may result after the first 100 M, one could improve their time and potentially break records that may have not been able to have been broken without the supplement.