It is not unlike myostatin inhibitors. There were countless companies on the internet claiming orally active myostatin inhibitor, which was complete bunk. But there was a time when people in the BB community latched on to this and were suggesting positive effects from myostatin inhibitors. With respect to the IGF-1 story, the actual science here is pretty complex, and what everyone overlooked was verifying the biologic activity, and that IGF-1 is structually almost identical to insulin, and all human grade insulin that works is recombinant. No way to chemically synthesize insulin, as it has 3 disulfide bonds that have to be generated in a biologic organism, so it is folded correctly to interact with the receptor. IGF-1 is absolutely the same as insulin in this respect, with the same 3 disulfide bonds. There are 100s of studies in the older scientific literature on properly producing insulin so it is folded and active. Before recombinant technology, insulin was derived from animal sources (bovine pancreas). Peptide companies are making inactive IGF-1......
