JimiThing
Moderator
IGF-1 LR3
So more and more I have been delving into the world of peptides. I have run several cycles of what I refer to as GH peptide stacks. Stacks that induce GH production; for example Sermorelin and GHRP2 & Mod GRF 1-29 and Ipamorelin. I have been very pleased with the results. I found the stacks to be very comparable to a low dose HGH run except you have got to pin a ton to achieve these results. I also ran TB500 for an injured shoulder and was more than pleased with it. In fact Id say TB500 is an astounding compound and I went from a skeptic to an avid advocate for its use in aiding in injury healing and recovery.
Now lately I have been looking into IGF as my next peptide I want to experiment with. As with all peptides before I run them I did extensive research on the peptide and also corresponded with many who have experience, both good and bad, with it as well. I decided with this one I would share the results of my research as well as my opinions on the peptide and how I personally am going to incorporate it for my own personal use.
First I wanted to look at IGF itself and see exactly what it does, what it would or could do for me. IGF is essentially the foundation for growth in humans. IGF stands for Insulin-Like Growth Factor. It is a peptide, that is it is a series of amino acids connected by covalent bonds. It is also a hormone. Its molecular structure is very similar to Insulin itself. It is at its highest levels during puberty and exerts anabolic effects throughout your entire life. It has a parallel relationship with growth hormone. That is the higher the levels of GH, the higher the levels of IGF. It is largely believe that the anabolic effects of GH itself can be directly attributed to the increase in IGF.
So far as you can see IGF sounds pretty great. Its an anabolic hormone largely responsible for anabolism and muscle growth within the body. More IGF= more muscle is basically what it would seem it comes down to. In theory that is pretty much the case, however in reality just like all things there are some limiting factors to IGF exerting its anabolic effects. IGF levels themselves are regulated by things like blood sugar levels, Insulin levels, Estrogen levels and much more within the body. Also IGF, in order for it to exert its effects, needs to have viable available receptors to bind to within the body. IGF receptors are located throughout the body and concentrated in muscle tissue and also in the gastro intestinal tract as well.
The next issue with IGF is not with true IGF itself but with the IGF we would as bodybuilders purchase and try to use to induce muscle growth. It seems simple, put together this amino acid chain bound with covalent bonds, inject it, and your good to go. Unfortunately that isn’t the reality. Some peptides can’t just be chemically synthesized like that. They need to be recombinantly synthesized, which means they are actually synthesized from a human DNA source. They also need to be properly folded. Folding a peptide is essentially ensuring the peptide assumes its native shape. You see in the process of synthesizing a peptide its actual molecular shape can be changed or altered. Many factors such as heat for example, can alter the original form or shape of the peptide. In order for the peptide to be biologically active in the body its original native shape must be reassumed. So what does that all mean? Well it means if you don’t get IGF that is recombinantly synthesized and properly folded you would essentially be injecting a form of IGF, yes, but that form would be totally useless and inactive within the body. It would be unable to bind to the IGF receptors necessary for it to illicit its effects. Quite often it seems to me this is the case with IGF that is sold, purchased and used by many bodybulders. I personally think that’s why some get and use IGF and say it does absolutely nothing. Because they are getting IGF that has not been properly manufactured to be biologically active in the human body so the reality is they are correct, it isn’t doing anything. I also think this explains the huge variation in IGF pricing throughout the peptide community. In my research looking at the process required to manufacture true biologically active IGF there is no way much of the IGF being sold is manufactured properly to be biologically active within the body. Proper manufacture is an expensive and time consuming procedure. Basically what you have is a bit of a scam based on lying by omission. You see yes much of what is being sold is in fact IGF, and they aren’t lying by calling it IGF, its just that it is useless IGF. With IGF it seems to me you do in fact to a large degree get what you pay for. The bottom line is you have to research and be sure the IGF you are buying is properly manufactured to be biologically active otherwise you are wasting your time and your money no matter how cheap the peptide is being sold for.
So based on the above information it becomes clear to me that you have to do some things to ensure one you do not limit IGFs ability to exert its effects in the body, and two you need to make sure you get true biologically active IGF.
Some things you can do to not limit IGFs effectiveness are eating a clean diet. Blood sugar spikes can have an adverse effect on IGF being able to illicit its effects. While diet is always important it becomes more important when a poor diet can render the compounds you are taking for muscle growth less effective. Also you want to make sure you maintain proper estrogen levels while using IGF. You see estrogen is necessary for IGF not only to be produced in the body, but to be effective in the body as well. This means don’t crush your e2 levels with an AI when using IGF. Now Im not saying let them run rampant, but manage them. You want estrogen to be present when using IGF. Also of note adequate protein intake is required for proper IGF production within the body but again this also applies to its ability to exert its effects when exogenously being induced into the body as well, meaning make sure to get adequate amounts of protein in the diet.
As far as number two you need to do your homework. You need to make sure the IGF you are getting is properly manufactured to biologically active. Do not fall for literary illusions such as as IGF is definitely 100% pure IGF because that may simply be a smoke screen. It is entirely possible for something to be 100% pure IGF, but if it wasn’t properly synthesized and folded it doesn’t matter at all, it wont do anything. For the record RUI is one of the few I have seen flat out say their IGF is recombinantly synthesized and properly folded. This explains to me their price difference when compared to some other IGF sources and now I see that they have even dropped their pricing making their IGF more affordable. The thing is this, it doesn’t matter how cheap the IGF you get is, if it isn’t made right it wont do anything. Its not like under dosed gear where you could simply take more. I use Rui for most of my ancillaries and peptides anyway but when it comes to my IGF run I will definitely be using them as I know it is IGF that will work.
OK so I know what to do and what not to do to make IGF most effective. I know what to look for when buying IGF to make sure it will actually do something. Now its time to put the plan together. IGF-1LR3, which is the IGF I will be using, has a very long active life. It doesn’t need to be site injected. It will spread systemically throughout the body attaching to IGF receptors. For this simple fact I will be injecting it just once a day, sub Q, in my abdomen. Dosing seems to range anywhere from 30-150mcg/day. I am going to settle in at around 100mcg/day. Much like many peptides you need to run this what some would consider long term. I plan on doing a 3 month run and taking it from there. Ill be logging my IGF run here and I am going to be starting it at the end of my AAS cycle. I figure this might be a great time to see if it can assist in gains retention through pct etc and see what it can do on its own, separate from all other compounds. I hope this little write up helped out some people. Its just the research information I picked up and how I formulated my IGF plan. Keep an eye out for my log and more info on IGF and what it actually can or cant do if you use real IGF and use it properly. I am truly hopeful it does what some people say it does. Either way I will let you guys know.
JimiThing
So more and more I have been delving into the world of peptides. I have run several cycles of what I refer to as GH peptide stacks. Stacks that induce GH production; for example Sermorelin and GHRP2 & Mod GRF 1-29 and Ipamorelin. I have been very pleased with the results. I found the stacks to be very comparable to a low dose HGH run except you have got to pin a ton to achieve these results. I also ran TB500 for an injured shoulder and was more than pleased with it. In fact Id say TB500 is an astounding compound and I went from a skeptic to an avid advocate for its use in aiding in injury healing and recovery.
Now lately I have been looking into IGF as my next peptide I want to experiment with. As with all peptides before I run them I did extensive research on the peptide and also corresponded with many who have experience, both good and bad, with it as well. I decided with this one I would share the results of my research as well as my opinions on the peptide and how I personally am going to incorporate it for my own personal use.
First I wanted to look at IGF itself and see exactly what it does, what it would or could do for me. IGF is essentially the foundation for growth in humans. IGF stands for Insulin-Like Growth Factor. It is a peptide, that is it is a series of amino acids connected by covalent bonds. It is also a hormone. Its molecular structure is very similar to Insulin itself. It is at its highest levels during puberty and exerts anabolic effects throughout your entire life. It has a parallel relationship with growth hormone. That is the higher the levels of GH, the higher the levels of IGF. It is largely believe that the anabolic effects of GH itself can be directly attributed to the increase in IGF.
So far as you can see IGF sounds pretty great. Its an anabolic hormone largely responsible for anabolism and muscle growth within the body. More IGF= more muscle is basically what it would seem it comes down to. In theory that is pretty much the case, however in reality just like all things there are some limiting factors to IGF exerting its anabolic effects. IGF levels themselves are regulated by things like blood sugar levels, Insulin levels, Estrogen levels and much more within the body. Also IGF, in order for it to exert its effects, needs to have viable available receptors to bind to within the body. IGF receptors are located throughout the body and concentrated in muscle tissue and also in the gastro intestinal tract as well.
The next issue with IGF is not with true IGF itself but with the IGF we would as bodybuilders purchase and try to use to induce muscle growth. It seems simple, put together this amino acid chain bound with covalent bonds, inject it, and your good to go. Unfortunately that isn’t the reality. Some peptides can’t just be chemically synthesized like that. They need to be recombinantly synthesized, which means they are actually synthesized from a human DNA source. They also need to be properly folded. Folding a peptide is essentially ensuring the peptide assumes its native shape. You see in the process of synthesizing a peptide its actual molecular shape can be changed or altered. Many factors such as heat for example, can alter the original form or shape of the peptide. In order for the peptide to be biologically active in the body its original native shape must be reassumed. So what does that all mean? Well it means if you don’t get IGF that is recombinantly synthesized and properly folded you would essentially be injecting a form of IGF, yes, but that form would be totally useless and inactive within the body. It would be unable to bind to the IGF receptors necessary for it to illicit its effects. Quite often it seems to me this is the case with IGF that is sold, purchased and used by many bodybulders. I personally think that’s why some get and use IGF and say it does absolutely nothing. Because they are getting IGF that has not been properly manufactured to be biologically active in the human body so the reality is they are correct, it isn’t doing anything. I also think this explains the huge variation in IGF pricing throughout the peptide community. In my research looking at the process required to manufacture true biologically active IGF there is no way much of the IGF being sold is manufactured properly to be biologically active within the body. Proper manufacture is an expensive and time consuming procedure. Basically what you have is a bit of a scam based on lying by omission. You see yes much of what is being sold is in fact IGF, and they aren’t lying by calling it IGF, its just that it is useless IGF. With IGF it seems to me you do in fact to a large degree get what you pay for. The bottom line is you have to research and be sure the IGF you are buying is properly manufactured to be biologically active otherwise you are wasting your time and your money no matter how cheap the peptide is being sold for.
So based on the above information it becomes clear to me that you have to do some things to ensure one you do not limit IGFs ability to exert its effects in the body, and two you need to make sure you get true biologically active IGF.
Some things you can do to not limit IGFs effectiveness are eating a clean diet. Blood sugar spikes can have an adverse effect on IGF being able to illicit its effects. While diet is always important it becomes more important when a poor diet can render the compounds you are taking for muscle growth less effective. Also you want to make sure you maintain proper estrogen levels while using IGF. You see estrogen is necessary for IGF not only to be produced in the body, but to be effective in the body as well. This means don’t crush your e2 levels with an AI when using IGF. Now Im not saying let them run rampant, but manage them. You want estrogen to be present when using IGF. Also of note adequate protein intake is required for proper IGF production within the body but again this also applies to its ability to exert its effects when exogenously being induced into the body as well, meaning make sure to get adequate amounts of protein in the diet.
As far as number two you need to do your homework. You need to make sure the IGF you are getting is properly manufactured to biologically active. Do not fall for literary illusions such as as IGF is definitely 100% pure IGF because that may simply be a smoke screen. It is entirely possible for something to be 100% pure IGF, but if it wasn’t properly synthesized and folded it doesn’t matter at all, it wont do anything. For the record RUI is one of the few I have seen flat out say their IGF is recombinantly synthesized and properly folded. This explains to me their price difference when compared to some other IGF sources and now I see that they have even dropped their pricing making their IGF more affordable. The thing is this, it doesn’t matter how cheap the IGF you get is, if it isn’t made right it wont do anything. Its not like under dosed gear where you could simply take more. I use Rui for most of my ancillaries and peptides anyway but when it comes to my IGF run I will definitely be using them as I know it is IGF that will work.
OK so I know what to do and what not to do to make IGF most effective. I know what to look for when buying IGF to make sure it will actually do something. Now its time to put the plan together. IGF-1LR3, which is the IGF I will be using, has a very long active life. It doesn’t need to be site injected. It will spread systemically throughout the body attaching to IGF receptors. For this simple fact I will be injecting it just once a day, sub Q, in my abdomen. Dosing seems to range anywhere from 30-150mcg/day. I am going to settle in at around 100mcg/day. Much like many peptides you need to run this what some would consider long term. I plan on doing a 3 month run and taking it from there. Ill be logging my IGF run here and I am going to be starting it at the end of my AAS cycle. I figure this might be a great time to see if it can assist in gains retention through pct etc and see what it can do on its own, separate from all other compounds. I hope this little write up helped out some people. Its just the research information I picked up and how I formulated my IGF plan. Keep an eye out for my log and more info on IGF and what it actually can or cant do if you use real IGF and use it properly. I am truly hopeful it does what some people say it does. Either way I will let you guys know.
JimiThing
