Rucker
New member
Dear Ology,
We are here to prove Liver Juice is the best supplement for preventing liver toxicity from oral steroids.
I would like to give away a bottle of Liver Juice to someone about to start a cycle and willing to have alanine transaminase (ALT) and aspartate transaminase (AST) liver enzymes tested during their cycle.
You need to:
- Be planning to use a methylated steroid
- Have used the same methylated steroid in the past
- Have had alanine transaminase (ALT) and aspartate transaminase (AST) tested during your past cycle of this methylated steroid.
The point of this research is to show that using Liver Juice before and during a cycle reduces steroid induced cholestasis. Cholestasis is the primary toxic effect caused from 17 alpha alkylated (17aa) steroids.
After a formal review of the most current scientific literature on milk thistle, it appears milk thistle has specific protective effects against anabolic/androgenic steroid induced liver toxicity.(14-19)
Use of methylated steroids (17aa) cause the liver to slow bile acid production, and create a bile acid insufficiency. If the liver gets clogged up enough a condition develops known as cholestasis. (11-19)
Luckily this liver condition is reversible. If you have suffered toxic effects from steroids (or other drugs) you can still improve the condition of your liver by improving bile acid levels. (14-20)
Studies have shown that milk thistle can reverse the decrease of bile acid production even during the use of methylated (17aa) steroids. So when steroids are in the liver inhibiting production of the beneficial bile acids and slowing bile acid outflow, milk thistle helps increase production of beneficial bile acids while enhancing the export of built up toxins (and methylated steroids) from the liver. (14-20)
Milk Thistle – Suffers from Poor Delivery
What’s most damaging to milk thistles reputation is that 90% of the milk thistle products on the market have very poor absorption at only about 8%. Our Liver Juice has up to 80% absorption efficiency due to the Liqua-Vade delivery system.(1-10)
Check out the comparison below -
We plan to prove how effective our Liver Juice is by gatherings data from actual steroid users. We will greatly appreciate your cooperation as will the entire community!
Please post up here if you are interested.
Jim Benvie,
Primordial Performance Marketing
Questions?
Phone – 1-800-568-2924
Email - info@primordialperformance.com
Visit - Primordial Performance
References-
1. Self-emulsifying drug delivery systems: Strategy for improving oral delivery of poorly soluble drugs.
Jing-ling et al.
Current Drug Therapy, 2007 Vol. 2, No. 1
2. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system.
Wei Wu et al.
European Journal of Pharmaceuticals and Biopharm. 63(3) (2006) 288-294
3. Formulation and biopharmaceutical evaluation of silymarin of SMEDDS
Woo et al.
Arch Pharm Res Vol 30, No 1, 82-89, 2007
4. Pharmacokinetics of silybin following oral administration of silipide in patients with extrahepatic biliary obstruction.
Schandalik R. et al.
Drugs Exp Clin Res. 1994;20(1):37-42.
5. Pharmacokinetic studies with silymarin in human serum and bile.
Lorenz D, et al.
Methods Find Exp Clin Pharmacol. 1984 Oct;6(10):655-61.
6. The solubility and bioequivalence of silymarin preparations
Schulz HU, et al
Arzneimittelforschung. 1995 Jan;45(1):61-4.
7. [Preparation of silybin-phospholipid complex and its bioavailability in rats][Article in Chinese]
Xiao YY, et al.
Yao Xue Xue Bao. 2005 Jul;40(7):611-7.
8. A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
Kidd P, et al.
Altern Med Rev. 2005 Sep;10(3):193-203.
9. Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects.
Barzaghi N, et al.
Eur J Drug Metab Pharmacokinet. 1990 Oct-Dec;15(4):333-8.
10. Silymarin: A review of pharmacological aspects and bioavailability enhancement approaches.
Nitin Dixit et al.
Indian J Pharmacol. 2007, Vol. 3 Issue 4, 172-179
11. Anabolic steroids and cholestasis
Nusinovici V.
Med Chir Dig. 1974;3(3):167-71.
12. Cholestasis due to anabolic steroids
Horký J, et al.
Cesk Gastroenterol Vyz. 1973 Dec;27(8):548-50.
13. Drug-induced cholestasis.
Velayudham LS, et al.
Expert Opin Drug Saf. 2003 May;2(3):287-304.
14. Beneficial drugs for liver diseases.
Muriel P, et al.
J Appl Toxicol. 2008 Mar;28(2):93-103. Review.
15. Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication.
Crocenzi FA, Roma MG.
Curr Med Chem. 2006;13(9):1055-74. Review.
16. Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP.
Crocenzi FA, et al.
Biochem Pharmacol. 2005 Apr 1;69(7):1113-20.
17. Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets.
Crocenzi FA, et al.
Hepatology. 2001 Aug;34(2):329-39.
18. Tauro alpha-muricholate is as effective as tauro beta-muricholate and tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat.
Kitani K, et al.
Hepatology. 1994 Apr;19(4):1007-12.
19. Tauro beta-muricholate is as effective as tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat.
Kanai S, et al.
Life Sci. 1990;47(26):2421-8.
20. Hepatoprotective effects of silymarin in androgenic-anabolic steroid-induced liver damage
Radovanovi D et al.
Med Pregl. 2003;56 Suppl 1:79-83.
