I was taking it 4x a day. Once when I woke up, once before my workout in the morning, once post-workout and once after dinner. The only supplement from those days that I really still stand by is creatine, but I don't know if the newer forms of arginine are really potent NO boosters at all or not. The big problem is that the supplement industry is able to market just about anything and can make all sorts of claims as long as they put on a disclaimer and their product doesn't actually do anything medically viable lol. It's when they have a product that can replace actual medicine is when Big Brother steps in (read: Primordial Performance) and raids them. It's sad really.