LAB RESULTS BACK - Docs/Vets please read!!!

[J steel]

OK fellas, here are some of my results, please read through and check out my questions at the end.

On my Comprehensive Metabolic Panel, two values were elevated:
UREA NITROGEN was 27 mg/DL, reference range is 7-25
BUN / CREATININE RATIO was 1.6 mg/DL, ref range is 0.5-1.4

My Lipid Panel turned out excellent:
CHOLESTEROL, TOTAL was 118 mg/DL, ref range is <200
HDL CHOLESTEROL was 47 mg/DL, ref range is >/=40
CHOLESTEROL/HDL RATIO was 2.5, ref range is <5.0
LDL CHOL, CALCULATED was 64 mg/DL, ref range is <130
TRIGLYCERIDES was 34mg/DL, ref range is <150

My Test levels turned out excellent as well:
TOTAL TESTOSTERONE was 1077 ng/DL, ref range is 260-1000
TESTOSTERONE, %, FREE was 1.7 percent, ref range is 1.0-2.7
TESTOSTERONE, FREE was 188.1 pg/ML, ref range is 50.0-210.0

OK, so here are my questions guys, I appreciate your input.

1) The doc thinks the two elevated kidney values could be due to the use of creatine as well as the fact that I had to fast before my blood was taken as was required for some of the tests. He said dehydration could have caused them to be high. Does this sound right to you other docs out there? I am going to drop the creatine and get retested in two weeks, and will not be fasting this time around. My doc wasn’t too concerned, but he just wants to make sure we can identify what caused the abnormal values.

2) I am shocked at my cholesterol values………so was my doc! Its not that I eat bad, I always have a pretty clean diet. However, I did run 1mg of Liquidex ED during my last cycle, for about 10 weeks, followed by 2.5mg of Femera ED for the remaining couple of weeks (ran out of Ldex) and into post cycle therapy (pct). I was so nervous to get this test done because I had heard Ldex and Femera can totally screw up your lipid panel. I did run Nolva ED from the start as well, could this have helped to keep them stable? Docs/Vets….what do you think?? I was going to run Aromasin with my next cycle to be safer, but with these results, I wonder if I should just run the Ldex or Femera again with the Nolva. What do you guys think??

3) I had to hold back giggling like a little girl when the doc told me my test levels!! I have been off since mid July, and did not get this blood work done till a month after my post cycle therapy (pct). I’m just very happy with my recovery……..barely lost weight, if any at all. I used HCG followed by Clomid/Nolva. Only another month to go till I start my winter bulker………I can’t wait!

SORRY FOR THE EXTREMELY LONG POST…………..THANKS FOR READING AND I APPRECIATE ANY INPUT!!!!

 

[snake]

I had high kidney values a few months back when I got my blood work done. scared the shit out of me. I think I took some bad Winstrol (winny). Or what I mean is that my Winstrol (winny) got infected cause I did not have clean enough habbits. any ways my levels came down the next time I was tested, thank god cause you do not want to mess with your kidneys. Hope it all works out.
peace

 

[DrJMW]

The slightly elevated BUN and creatinine could easily be due to dehydration. Now that you have a baseline. you can monitor your kidney function. BTW, it is possible to have normal lipid profile, high-normal testosterone levels and otherwise normal function. Just remember to keep your eye on everything.

 

[J steel]

DrJMW, I was hoping I'd hear from you.

Glad to see you agree the elevated BUN/creatinine is most likely due to dehydration at the time of the test. Like I said, I will get a retest done while fully hydrated just to make sure levels go down.

I'm a little confused as to what you were implying by saying it is possible to have normal lipid profile, high-normal testosterone levels and otherwise normal function...........were you saying that contrary to what some may think, it is possible for someone who uses steroids to have all of the above, and overall good health? I hope my reactions didn't make it seem that I did not believe this..........I am just relieved to see that I am playing this game the right way, so yea, I'm a little excited.

Whats your opinion on choosing aromasin, as opposed to ldex or femera. Is is still worth it to go the safer route?

 

[DTOX]

Holy jesus...

Test levels over 1000 and the cholesterol levels of a vegetarian marathon runner!!!

I can't even explain how envious I am.

 

[DrJMW]

It is possible to have high Testos levels and be healthy. Just remember that everybody is different. Blood testing is the key to see how the body reacts to various levels of AAS. If you are doing 1g of Anabolic Androgenic Steroids (AAS) weekly and your lipid profile looks like hell, then you need to lower your Anabolic Androgenic Steroids (AAS) dosing to the point where the blood tests are normal. It is as simple as that--Maximal Effective Dose.

 

[DADAWG]

Holy jesus...

Test levels over 1000 and the cholesterol levels of a vegetarian marathon runner!!!

I can't even explain how envious I am.

bro im 5-9 and pushin 300 pounds and i eat more than some third world countries , my highest cholesterol reading ever was 150 , i was on a heavy cycle then and by the next time i had it checked off cycle it was back to 130 , some people for whatever reason arent prone to high cholesterol .

 

[hhajdo]

2) I am shocked at my cholesterol values………so was my doc! Its not that I eat bad, I always have a pretty clean diet. However, I did run 1mg of Liquidex ED during my last cycle, for about 10 weeks, followed by 2.5mg of Femera ED for the remaining couple of weeks (ran out of Ldex) and into post cycle therapy (pct). I was so nervous to get this test done because I had heard Ldex and Femera can totally screw up your lipid panel. I did run Nolva ED from the start as well, could this have helped to keep them stable? Docs/Vets….what do you think?? I was going to run Aromasin with my next cycle to be safer, but with these results, I wonder if I should just run the Ldex or Femera again with the Nolva. What do you guys think??

Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S. Related Articles, Links


Pharmacology and pharmacokinetics of the newer generation aromatase inhibitors.

Buzdar AU.

Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA. abuzdar@mdanderson.org

The newer generation aromatase inhibitors (AIs) as a class show efficacy and tolerability benefits over previously established treatments in postmenopausal women with advanced breast cancer. At clinically administered doses, the plasma half-lives of anastrozole (1 mg once daily), letrozole (2.5 mg once daily), and exemestane (25 mg once daily) are 41-48 h, 2-4 days, and 27 h, respectively. Time to steady-state plasma levels is 7 days for both anastrozole and exemestane and 60 days for letrozole. Androgenic side effects have only been reported with exemestane. Anastrozole treatment has no impact on plasma lipid levels, whereas both letrozole and exemestane have an unfavorable effect. From indirect comparisons, anastrozole shows the highest degree of selectivity compared with letrozole and exemestane, in terms of a lack of effect on adrenosteroidogenesis. To date, there are no data suggesting any major differences in clinical efficacy between the newer generation AIs anastrozole and letrozole. Based on the observed pharmacological profiles, however, it cannot be assumed that the AIs will display the same tolerability and safety profiles when given for extended periods of time in the adjuvant setting. The effects of anastrozole, letrozole, and exemestane are being investigated in the adjuvant setting, and these data will elucidate the possible long-term consequences of the pharmacological effects reported after short-term exposure.

-----------------------------

Cancer. 2002 Nov 1;95(9):2006-16. Related Articles, Links


An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane.

Buzdar AU, Robertson JF, Eiermann W, Nabholtz JM.

Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. abuzdar@mdanderson.org

BACKGROUND: The newer generation, nonsteroidal aromatase inhibitors (AIs) anastrozole and letrozole have shown superior efficacy compared with tamoxifen as first-line treatments and compared with megestrol acetate as second-line therapy in postmenopausal women with advanced breast carcinoma. In an open-label, Phase II trial, it was reported that exemestane showed numerical superiority compared with tamoxifen for objective response and clinical benefit. Because these agents ultimately may be administered for periods of up to 5 years in the adjuvant setting, it is of increasing importance to assess their tolerability and pharmacologic profiles. METHODS: In the absence of data from direct clinical comparisons, the published literature was reviewed for the clinical pharmacology, pharmacokinetic characteristics, and selectivity profiles of anastrozole, letrozole, and exemestane. RESULTS: At clinically administered doses, the plasma half-lives of anastrozole (1 mg once daily), letrozole (2.5 mg once daily), and exemestane (25 mg once daily) were 41-48 hours, 2-4 days, and 27 hours, respectively. The time to steady-state plasma levels was 7 days for both anastrozole and exemestane and 60 days for letrozole. Androgenic side effects have been reported only with exemestane. Anastrozole treatment had no impact on plasma lipid levels, whereas both letrozole and exemestane had an unfavorable effect on plasma lipid levels. In indirect comparisons, anastrozole showed the highest degree of selectivity compared with letrozole and exemestane in terms of a lack of effect on adrenosteroidogenesis. CONCLUSIONS: All three AIs demonstrated clinical efficacy over preexisting treatments. However, there were differences in terms of pharmacokinetics and effects on lipid levels and adrenosteroidogenesis. The long-term clinical significance of these differences remains to be elucidated. Copyright 2002 American Cancer Society.


http://www.steroidology.com/forum/showthread.php?s=&threadid=6472

 

[J steel]

well this just confused the shit out of me

all along i have read that ldex and femera affect cholesterol negatively, while exemestane has no effect.

am i reading this wrong or is it saying that ldex is preferrable instead??

 

[hhajdo]

You're not reading it wrong.