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CJC-1295 is a tetra bond substituted analog of CJC-1288 (GHRH with 44-amino acids bond) with 15 aminos removed, leaving a total of 29 amino acids, and bound to DAC which is also known as Drug Affinity Complex, and CJC-1295 is often referred to as GHRH with Drug Affinity Complex which allows it to bind to albumin in plasma resulting in the preventing degradation.
In CJC-1295 DAC, the manipulation of growth hormone is with a D-Ala at the 2-position, a glutamine (Gln) at the 8-position, an Ala at the 15-position, and a leucine (Leu) at the 27-position.D-Ala, Gln, Ala, and position 2 creates a much
more stable peptide with the substitution at position 2 site to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to increase biological action, and position 27 to prevent methionine oxidation. By utilising the Drug Affinity Complex technology to GRF, the peptide selectively clings to circulating albumin after subcutaneous injection, thus prolonging its half-life. (Professor Filimanov)
As you may notice it’s basically Semorelin with 15 amino acids removed. This was because semorelin degrades too rapidly to really make it a logical cost worthy option.
So researchers bonded it with an attached 3-maleimidopropionic acid orMPA unit, this results in binding to albumin after an exogenous injection into blood plasma, and creates a far longer half life, this is the DAC aka drug affinity complex I made reference to earlier.
The mechanism, by which it works, is through GHRH, or growth hormone releasing hormone. In the average healthy human body, large amounts of growth hormone are stored in the pituitary gland which is located below the HPTA. The cells within the pituitary gland release growth hormone in response to the signaling by the GHRH (Growth Hormone Releasing Hormone). Next the peptide Ghrelin is a GHRP or GHRH memetic, is then inhibited from secreting these stores by Somatostatin. GHRH and Ghrelin act on different areas of somatotropes. GHRP and Ghrelin increase the number of somatotropes releasing GH but not the amount of GH secreted by each actual cell. A consistent research from studies confirmed repeatedly in that GHRH is effective at jump starting GH secretion and longer acting analogs do raise the overall success.
GHRH affects both the number of secreting cells and even more the amount that they are essentially able to secrete. GHRH and Ghrelin are released in specific patterns that vary depending on what the individual in the process is doing, or has been doing post training. Something to note is CJC-1295 DAC has been proven to stimulate slow wave sleep, and this is the period of sleep when most of your body’s recovering takes place on muscles, tissues, cartilage etc. Now most people will make sufficient GH in their own pituitary gland, but not everyone can release it in the amounts needed due to medical conditions, which from a medicinal point CJC-1295 DAC can be crucial for health.
Read the rest here
Needtogetaas CJC-1295 DAC Profile « Need To Build Muscle Inc. Official Blog
In CJC-1295 DAC, the manipulation of growth hormone is with a D-Ala at the 2-position, a glutamine (Gln) at the 8-position, an Ala at the 15-position, and a leucine (Leu) at the 27-position.D-Ala, Gln, Ala, and position 2 creates a much
more stable peptide with the substitution at position 2 site to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to increase biological action, and position 27 to prevent methionine oxidation. By utilising the Drug Affinity Complex technology to GRF, the peptide selectively clings to circulating albumin after subcutaneous injection, thus prolonging its half-life. (Professor Filimanov)
As you may notice it’s basically Semorelin with 15 amino acids removed. This was because semorelin degrades too rapidly to really make it a logical cost worthy option.
So researchers bonded it with an attached 3-maleimidopropionic acid orMPA unit, this results in binding to albumin after an exogenous injection into blood plasma, and creates a far longer half life, this is the DAC aka drug affinity complex I made reference to earlier.
The mechanism, by which it works, is through GHRH, or growth hormone releasing hormone. In the average healthy human body, large amounts of growth hormone are stored in the pituitary gland which is located below the HPTA. The cells within the pituitary gland release growth hormone in response to the signaling by the GHRH (Growth Hormone Releasing Hormone). Next the peptide Ghrelin is a GHRP or GHRH memetic, is then inhibited from secreting these stores by Somatostatin. GHRH and Ghrelin act on different areas of somatotropes. GHRP and Ghrelin increase the number of somatotropes releasing GH but not the amount of GH secreted by each actual cell. A consistent research from studies confirmed repeatedly in that GHRH is effective at jump starting GH secretion and longer acting analogs do raise the overall success.
GHRH affects both the number of secreting cells and even more the amount that they are essentially able to secrete. GHRH and Ghrelin are released in specific patterns that vary depending on what the individual in the process is doing, or has been doing post training. Something to note is CJC-1295 DAC has been proven to stimulate slow wave sleep, and this is the period of sleep when most of your body’s recovering takes place on muscles, tissues, cartilage etc. Now most people will make sufficient GH in their own pituitary gland, but not everyone can release it in the amounts needed due to medical conditions, which from a medicinal point CJC-1295 DAC can be crucial for health.
Read the rest here
Needtogetaas CJC-1295 DAC Profile « Need To Build Muscle Inc. Official Blog
