"
Avodart
.2 DURATION
A. SINGLE DOSE:
1. PLASMA DIHYDROTESTOSTERONE REDUCTIONS, ORAL: 3 to 8 weeks (healthy subjects) (Olsson Gisleskog et al, 1998).
a. Time of sustained decreases in plasma 5-alpha-dihydrotestosterone (DHT) levels after single oral doses of 1 to 40 mg in healthy subjects; duration of DHT suppression was dose-related.
2.3.5 HALF-LIFE
2.3.5.1 PARENT COMPOUND
A. ELIMINATION HALF-LIFE: up to 5 weeks (Olsson Gisleskog et al, 1999; (Prod Info Avodart(TM), 2004).
A. MECHANISM OF ACTION
1. Dutasteride is a dual 5-alpha-reductase inhibitor indicated for the treatment of benign prostatic hyperplasia (BPH) (Anon, 2001; Olsson Gisleskog et al, 1998). The 5-alpha-reductase enzyme is responsible for converting testosterone to 5-alpha-dihydrotestosterone (DHT), which is considered primarily responsible for signs/symptoms of BPH (Olsson Gisleskog et al, 1998; Makridakis et al, 2000). Two isozymes of 5-alpha-reductase are present in humans, type 1 (mainly in Liver and skin) and type 2 (predominant form in the prostate) (Olsson Gisleskog et al, 1999; Olsson Gisleskog et al, 1998).
2. Enzymologic studies have demonstrated that Dutasteride is an irreversible competitive inhibitor of 5-alpha-reductase types 1 and 2, which results in significant reductions in circulating DHT levels (Olsson Gisleskog et al, 1998; Olsson Gisleskog et al, 1999a). Data from animal studies have suggested that Dutasteride is more potent than finasteride, a selective and irreversible 5-alpha-reductase type 2 inhibitor; greater falls in DHT concentrations were observed with Dutasteride (Olsson Gisleskog et al, 1998; Olsson Gisleskog et al, 1999).
3. In healthy subjects (Olsson Gisleskog et al, 1998), Dutasteride in single oral doses of 1 milligram (mg) or higher reduced DHT concentrations by 70 to 95%, with levels remaining decreased for 3 to 8 weeks; the degree and duration of DHT suppression were dose-related. After oral finasteride 5 mg, DHT levels were suppressed by approximately 80%, and the duration of suppression was shorter (1 to 2 weeks). This study indicated that the potency of Dutasteride was about 3-fold that of finasteride for inhibition of 5-alpha-reductase type 2. Near-full blockade of both isozymes occurred with Dutasteride 10 mg or greater."
"Avodart® (Dutasteride)
Avodart is used to treat urinary symptoms of Enlarging Prostate. Prostate growth is caused by a hormone in the blood called dihydrotestosterone (DHT). Avodart lowers DHT production in the body, leading to shrinkage of the enlarged prostate in most men. Just as your prostate became large over a long period of time, reducing the size of your prostate and improving your symptoms will take time. While some men have fewer problems and symptoms after 3 months of treatment with Avodart, a treatment period of at least 6 months is usually necessary to see if Avodart will work for you. Studies have shown that treatment with Avodart for 2 years reduces the risk of complete blockage of urine flow (acute urinary retention) and/or the need for surgery for benign prostatic hyperplasia.
there probably won't be much info on it and hairloss treatment as it will be buried in clinical trial data.
It is only approved for benign prostatic hypertrophy treatment by the FDA as GSK didn't pursue the label claim and or application for hairloss as it would only be a $500 million dollar a year product.
But if you find the right doc he will prescribe it for hariloss (the off label claim) as it is reported to have less sexual sides or interference with function as Proscar etc. Shame they didn't pursue it.
