Lump devloping by nipple even though estradiol is fine at trough.

[Havasu]

My TRT protocol is as follows:

70mg Test C 2x per week, every 3.5 days

HCG 400iu 2x per week the day before Test shots.

Calcium D-Glucarate 3000mg-4000mg per day for estrogen control


At last check my estradiol had been between 30-36 at trough, and all was well. I stopped checking e2 as regularly as I was, and I had stopped checking my nipples, because e2 was good and the little lumps I had developed when my e2 was high were gone from taking Tamoxifen, 40mg a day.

Last week something brushed up against my left nipple, and I felt something and there was a hard mass behind the nipple stretching towards the outside (pointing towards the armpit), so I had my e2 checked. It was taken Thursday morning, and my next test shot at the time was Thursday night. I just got the result back and it was 27 at trough. That's absolutely fine. So, I'm a little confused. The only thing I can rationalize is that initially my e2 is spiking too high during peak which is causing me to develop the nodules. Does this make sense? If so, what can I do to prevent this? Would arimidex provide more control during peak? I've been trying to avoid arimidex as my TRT doc says it suppresses your natural growth hormone production.

The only other things I'm taking right now are:

Ipamorelin & CJC-1295 w/o DAC - 100mcg each 3x per day

MelanotanII - I've already done my initial loading so I take about 1mg every few days currently.

Tamoxifen - 40mg a day until the nodule is gone.

 

[Megatron28]

Wouldn't hurt to check your peak levels. Could be a prolactin issue as well.

 

[Jimstigator]

Havasu, we have talked before... And I think we are still in similar situations. Nipples super sensitive to estrogen. I'd be curious what your E is at peak. Your doses would put my nips through the roof, even if I felt like my E was being managed.

30+, for me, is high and gives worse agitation. I am still working on it but it's starting to seem like my best bet is keeping TT levels extremely steady (EOD injections? ) so I can find the sweet spot in estrogen. Even that small swing from like 20-30 gets my gyno prone nips itchy/burning. I've been trying some adex but then I just bounce too low followed by too high. Starting today, I am moving to 22mg test cyp EOD (approx 77mg per week) and 50iu hcg daily. While neither of those doses are optimal for other things... I need some nip relief. What's a libido when your titties are lit up around the clock.

-Jim

 

[hiram1st]

I have the same issue painful hard lump flare ups but when I started .5mg of adex e3.5d same as test injection seems to keep everything at good levels. I no longer base symptom ology strictly by E2 level but T:E ratio which tends to keep my E2 below 20 on regular essay.

Doing this no more flare ups, morning wood always and great libido. Now that I started a blast there back and adjusting adex to get T:E ratio lower. I'm also using 30mg of raloxifene. I guess everyone is different and need to find what's works for you .

 

[Beefy Nugz]

I have the same issue painful hard lump flare ups but when I started .5mg of adex e3.5d same as test injection seems to keep everything at good levels. I no longer base symptom ology strictly by E2 level but T:E ratio which tends to keep my E2 below 20 on regular essay...

Doing this no more flare ups, morning wood always and great libido. Now that I started a blast there back and adjusting adex to get T:E ratio lower. I'm also using 30mg of raloxifene. I guess everyone is different and need to find what's works for you .

just out of curiosity, where do you think that puts you on a sensitive essay?

 

[hiram1st]

It was at 9

 

[Jimstigator]

It was at 9

You stay on Ralox? What is tcyp dose and TT when running standard regimine that included the .5mg adex E3.5D?

 

[hiram1st]

Test e,, 75mg E3.5D, 749 peak tt. No don't run ralox all the time just at flare ups till subsides. But at that protocol for 6 weeks I had no flare ups.

You and I started trt around the same time and I've followed some of your threads and we've had some of the same issues. We definitely don't fit into the mean average of trt patients.

I know when I started I was constantly trying to get my sensitive e2 up to between 30 and 40 because that is what is taught here and on almost every trt forum I've visited and lets not forget if Crisler says it then that has to be right (lol)and the higher my sensitive e3 got the more flare ups I got.

This is an individual thing and I guess as long as my e2 is in a healthy spot and I have know flare ups I'll keep it where it needs to be.

 

[Jimstigator]

Test e,, 75mg E3.5D, 749 peak tt. No don't run ralox all the time just at flare ups till subsides. But at that protocol for 6 weeks I had no flare ups.

You and I started trt around the same time and I've followed some of your threads and we've had some of the same issues. We definitely don't fit into the mean average of trt patients.

I know when I started I was constantly trying to get my sensitive e2 up to between 30 and 40 because that is what is taught here and on almost every trt forum I've visited and lets not forget if Crisler says it then that has to be right (lol)and the higher my sensitive e3 got the more flare ups I got.

This is an individual thing and I guess as long as my e2 is in a healthy spot and I have know flare ups I'll keep it where it needs to be.

Amen. I still fight the battle in my head between what I am told and what actually works for me. Notably, I feel like shit with high TT, no matter where my estrogen is. Yet I still go for high TT levels. Further - I chase "ideal" numbers instead of going by feel. Only recently have I started to back off and things are looking up. Plus, everyone is just so different. 70mg E3.5D has me well into the 1000s peak. 40mg E3.5D puts me at 750ish. Following the numbers and not how I feel has kept me from finding the holy grail of my treatment over the past year.

I think the OP Havasu has the same struggle. Like me, his nips just don't react well to estrogen. Some guys can keep a sensitive E of 50 and be fine. Mine start to bug out at like 26

-Jim

 

[Jimstigator]

Been thinking about this more as I have the same issues. SHBG plays a HUGE role in hormones and is often overlooked on the forums.

For testosterone, we have two tests. Total and Free. Free being the levels of T available for receptors after SHBG has done its binding. SHBG also effects estrogen. Not only in how much your body creates, but also how its felt. Take two guys, each comes back with an E2 of 30. For a guy with a normal-high SHBG, 30 is prime time. For a guy like myself with a low SHBG, 30 can feel like high estrogen as less of it is bound up.

I suppose another reason to play the game based on feel first, numbers second.

-Jim

 

[Havasu]

When I've had SHBG checked it's come back consistently at 33.

 

[Jimstigator]

When I've had SHBG checked it's come back consistently at 33.

That's a good number.

-Jim

 

[JimiThing]

Have you considered exemestane? Less impact on IGF than dex and very forgiving option when it comes to an ai.

 

[Havasu]

Have you considered exemestane? Less impact on IGF than dex and very forgiving option when it comes to an ai.

I've read about it, but I haven't considered it. It seems like the articles I've read always point back to adex. I know Exemestane (Aromasin) has a shorter half life if I'm correct. So, how would you dose it for mild estrogen control. I figure if I'm controlling it with calcium d-glucarate at 3000mg-4000mg per day, It probably won't take much of an AI.

 

[JimiThing]

6.25mg/day id say....

 

[Megatron28]

Been thinking about this more as I have the same issues. SHBG plays a HUGE role in hormones and is often overlooked on the forums.

For testosterone, we have two tests. Total and Free. Free being the levels of T available for receptors after SHBG has done its binding. SHBG also effects estrogen. Not only in how much your body creates, but also how its felt. Take two guys, each comes back with an E2 of 30. For a guy with a normal-high SHBG, 30 is prime time. For a guy like myself with a low SHBG, 30 can feel like high estrogen as less of it is bound up.

I suppose another reason to play the game based on feel first, numbers second.

-Jim

What happened to bioavailable?

 

[Jimstigator]

What happened to bioavailable?

He's cool too, and I forgot to invite him the party. An even closer representation to what can actually be used by the body right? Without looking I believe bioavailable is both free plus weakly bound, a result of SHBG levels.

-Jim