methylated orals vs non methylated orals
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halfwit
I like turtles.
As far as I understand it, methylating a compound at the 17-aa position allows it to bypass the liver on the first pass, maintaining the potency of the drug. This of course makes it slightly toxic to the liver, but you keep the full effect. There aren't very many non 17-aa orals out there, but they do exist.
halfwit
I like turtles.
Hexadrone? Isn't that a prohormone?
halfwit
I like turtles.
Ahh, yeah - I don't fully understand how they can get away with making some of them non-methylated yet still retain potency. I know it has something to do with modifying the carbon chain so the body tears away that modification first - allowing the rest of the compound to pass. As it's the liver's job to do this stripping, it puts a strain on the organ.
It's really interesting how they are able to do that at the molecular level, and a shame I don't have enough of a background in chemistry to fully grasp it all.
It's really interesting how they are able to do that at the molecular level, and a shame I don't have enough of a background in chemistry to fully grasp it all.
https://www.mrsupps.com/Products/108/6-MDROL/
Mr supps phs arw the real deal. They actually work. Thats why I'm curious about their new non methylated product. Someone needs try it lol
Mr supps phs arw the real deal. They actually work. Thats why I'm curious about their new non methylated product. Someone needs try it lol
Normal oral steroids are ineffective when administered orally bc of the hepatatic first pass metabolism of the liver. On the "first pass", these drugs are metabolized so much by the liver that by the time they reach the circulatory system, the concentration is much much lower and their basic structure has been broken down already. When you replace the hydrogen atom at the 17th alpha position with a carbon atom, this is referred to as alkylation which makes the steroid resistant to break down from the liver and therefore the first pass effect. Oftentimes this carbon atom is added with a methyl group (CH3) but you do see some ethyl groups added (C2H25).
Most of your common orals dbol, Winstrol (winny), Anavar, anadrol, etc require this to be effective. The alkylation process also changes the action of the compound. Some major changes you'll notice is an increase in tendency for it to produce estrogen related side effects even though it lowers the affinity for interaction with aromatase bc it makes a more potent form of estrogen. It lowers the propensity to bind to androgen receptors but by increasing the half life and therefore the the length of time it exists in an unbound state, it causes it to be a more potent anabolic and androgenic.
Non-methylated orals include Proviron, Primobolan, Andriole. Proviron and primo are alkylated at the 1 position with CH3 (methyl) which is a much weaker bond. The benefits of non-alkylated orals are obvious: very little relative liver toxicity but the cons are a much shorter half-life and they're less active in a mg for mg basis.
Most of your common orals dbol, Winstrol (winny), Anavar, anadrol, etc require this to be effective. The alkylation process also changes the action of the compound. Some major changes you'll notice is an increase in tendency for it to produce estrogen related side effects even though it lowers the affinity for interaction with aromatase bc it makes a more potent form of estrogen. It lowers the propensity to bind to androgen receptors but by increasing the half life and therefore the the length of time it exists in an unbound state, it causes it to be a more potent anabolic and androgenic.
Non-methylated orals include Proviron, Primobolan, Andriole. Proviron and primo are alkylated at the 1 position with CH3 (methyl) which is a much weaker bond. The benefits of non-alkylated orals are obvious: very little relative liver toxicity but the cons are a much shorter half-life and they're less active in a mg for mg basis.
If its non-methylated at the 17th position then it means it will start to break down much sooner than something like dbol for instance. They either had to have increased the dosage to make up for this or used one of the weaker alkylations to prevent first pass effect but which would reduce half life as well
halfwit
I like turtles.
Primo is methylated but at the 1 position not the 17th position. That difference is key. Methylate it at the 17th position and the alkyl group cannot be removed metabolically. Methylate it at the 1st position and it resists first pass effect but it gets absorbed through the imtestinal lymphatic duct.
halfwit
I like turtles.
I think of it as injecting test vs popping a few anadrol. I am still curious how they're able to have such efficacy given the liver is going to gobble up a bunch of the drug.
Damn Doc, you're on a roll today! Edumacatin' the masses!
I think of it as injecting test vs popping a few anadrol. I am still curious how they're able to have such efficacy given the liver is going to gobble up a bunch of the drug.
Damn Doc, you're on a roll today! Edumacatin' the masses!
A typical dose is 100mg a day for that stuff from what I've read plus they claim "it's not liver toxic due to a chloro group at the C6 position". I can't find anything to back or discredit this statement but when they say a pro-hormone is "non-toxic" I tend to believe a good deal of that is marketing gimmick.
halfwit
I like turtles.
Probably easier than saying "not hepatotoxic" which might throw off the average Joe looking to cycle some prohormones. Pretty nifty though if it works! That could make the choice of a kicker much easier if it's anywhere as anabolic as some of its AAS cousins.
RickRock13
New member
Non-methylated prohormones such as 6-mdrol and Katanadrol v3.0 puts a significantly less amount of stress on the liver due to their very low toxicity levels. They usually produce slightly less gains than methylated orals, but the side effects and suppression are lower and they can be ran for longer periods of time without making your liver enzyme values go out of range. They carry a lower benefit to risk than methylated orals because of those reasons. They also make great stackers since they do not add to overall toxicity or add to side effects.
Jbranken
New member
Good post! A lot of good posts in this thread. Non methyls can definitely be effective but i always stack them with methyls. Other great non methyls that come to mind (other than 6-mdrol) is the old eq-plex (boldione) and furuza. I loved stacking them methyls
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