The following is the list of serum estradiol tests we recommend be obtained to help monitor your body's hormone levels and metabolism (rate of use of hormones)
WHAT'S SO BAD ABOUT STANDARD SERUM ESTRADIOL TESTS AVAILABLE WORLDWIDE ?
The standard estradiol (E2) tests available worldwide are effectively "female-only" E2 tests which are designed to be accurate when measuring a normal menstruating female's optimum E2 levels.
A normal menstruating female's optimum E2 levels are between 10 and 50 times greater than a normal healthy males' E2 levels.
We see the effect of this lack-of-sensitivity of the female-only E2 test, when measuring a male's E2, in the following way:
If you want to use the non-sensitive results for tweaking your hormone modulation therapy, then you can use them to a very limited degree, and by using them you'll take a lot longer to stabilize your hormone levels.
The following sample table helps show the accuracy comparison of E2 measurements:
Code:
patient=chilln
month=OCTOBER
sensitive E2.........my non-sensitive E2
10........................50
15........................55
20........................50
25........................57 <--- chilln's E2 was optimum on this day
30........................65
Code:
patient=chilln
month=NOVEMBER
sensitive E2.........my non-sensitive E2
10........................60
15........................60
20........................66
25........................64 <--- chilln's E2 was optimum on this day
30........................70
From the above 2 tables we learn some critical things:
1) within a month, the non-sensitive results do not consistently increase when sensitive E2 consistently increases
2) from month to month, the same value of sensitive E2 gave 2 different results for non-sensitive E2, which varied by 10 units
3) I need the accuracy of my E2 measurement to be within 5 units to help me determine when my E2 is optimum
####
The absolute numbers will vary with each individual, but the reliability and the accuracy of the three testing technologies will remain the same.
The relationships certainly depend on the individual (in conjunction with their medical professional adviser), managing their hormone levels in a steady state fashion, such that their daily E2 fluctuations aren't huge.
While anyone can mess with their T and E2 levels and never achieve steady state, that is not the objective of hormone modulation therapy. Achieving steady state levels is critical to success of all hormone modulation therapy, and that is the underlying assumption behind the above table.
Note: It is not true that a person's serum E2 levels stay constant, even when their total daily E2 production (which is what is measured via 24hr urinary E2) will be approximately constant.
Note: provided the person doses their horomone modulating substances regularly, at similar times each day, and provided their mental and physical stressors and diet are also reasonably reliable, then the person will reliably measure E2 levels which correspond to their urinary E2 levels.
WHAT'S SO BAD ABOUT SALIVARY ESTRADIOL TESTS ?
The fundamental problem with estradiol salivary testing stems from the problems with testosterone salivary testing.
In males, estradiol is synthesized from testosterone via aromatase enzymes. Since human saliva contains enzymes which synthesize testosterone from androstenedione, therefore human saliva contains higher concentrations of testosterone than serum, and thus human saliva estradiol levels are also tainted because salivary estradiol is infleunced by salivary testosterone, and salivary testosterone is not indicative of a males' testosterone metabolism.
This was discussed in detail in Testosterone Serum Tests
The researchers who discovered the problems with testosterone salivary metrics did not go specifically address salivary estrogens, but my conclusion would be that excess testosterone in the salivary gland cells might then aromatase into estradiol provided the salivary glands also contain aromatase P450 enzymes ( I haven't had time to confirm or deny the presence of this enzyme in salivary gland cells)
SO WHICH ESTRADIOL TESTS ACTUALLY DO RELIABLY MEASURE A MALE'S ESTRADIOL LEVELS ?
The sensitive and ultrasensitive serum E2 tests, which give males a reliable metric for our serum E2 levels, are as follows:
WORLDWIDE ex USA
(effectively none, because transporting blood is a hazardous substance, and the cost of transporting hazardous substances makes the effort prohibitively expensive)
AUSTRALIA
none, sorry folks
CANADA
none, sorry folks
GERMANY
For German residents to get a sensitive E2 test done, they need to either:
a) work with a medical professional adviser who has lab requsition forms from any of the following labs:
or:
b) take a generic lab requesition to one of the following labs:
and:
c) Request the doctor to write "estradiol ausschließlich" on the lab requisition.
Note that Dadoo provided the following, and Dadoo lives close enough to these labs. Judging by the number of labs in one area, we estimate there are many more labs in Germany which also offer E2 sensitive testing.
West LG Duisburg Medical Center Duisburg-Ruhrort
Ruhrorter Str. 195
47119 Duisburg
Ärztliche Apparategemeinschaft Rhein/Ruhr Laborwerk
Willy-Brandt-Platz 4
45127 Essen
Labor Alfredstrasse
Dres.K.-T.Joachim und B.Leeser
OT: Rüttenscheid
Alfredstr. 28
45130 Essen
UK
none, sorry folks
USA
LABCORP 140244 (uses RIA)
https://www.labcorp.com/datasets/lab...o/sr016000.htm
put 140244 into the test number field at the above page
Ref range for males: 3 - 70 pg/mL
or
b) Mayo Labs #81816 (uses LC-MS/MS)
http://www.mayomedicallaboratories.c...rpretive/81816
Reference range for males: 10 - 40 pg/mL
or
c) When Quest don't sabotage their own test: Quest Ultra Sensitive Estradiol 30289X (uses LC-MS/MS)
http://www.questdiagnostics.com/hcp/...EndoManual.pdf
page 72
Ref range for males: <= 29 pg/mL
Unfortunately this test is too frequently sabotaged by their own Phlebotomists and testers, and can therefore give either very accurate results when not sabotaged, and unreliable results when sabotaged.
Copyright is retained by chilln: 2008, 2009, 2010, 2011
