Nolvadex for Women

Nolva is categorized as a mixed agonist and antagonist depending on the tissue. There was an anecdotal study done on a female body builder who took 20-40mg/day of Nolvadex and the sides she experienced are up to you to decide if they're worth:

Why would somebody take that much Nolvadex a day? I mean its half life and elimination rate is ridiculously long, like 5 days or so, seems like she could have halved that dose and taken it every 2-3 days with less sides.

Thanks for the abstracts, I'm a real science-oriented person so I appreciate when people link me to medical journals and what not. I'll go check them out and read them right now.
 
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Better jump on that homework ASAP buddy bc you owe me a tren/test/seltzer water cocktail as soon as my flight lands ;)

Egads, thanks for the amazing idea.. :Puke: :Puke: :Puke:

I seriously do wonder if anyone has tried to pansy out of pinning and took IM testosterone orally... Ahh, the stupidity of the human race knows no bounds. :D
 
I seriously do wonder if anyone has tried to pansy out of pinning and took IM testosterone orally... Ahh, the stupidity of the human race knows no bounds. :D

Personally, I'm actually thinking about administering oral steroids rectally.... :laugh:

I MEAN THINK ABOUT IT!!!! Not only would it probably work, it will probably make the drug 3 times more effective, and reduce toxicity to the liver. I know that "bootybumping" works with virtually every psychoactive substance out there that is water-soluble, and is pretty much the next most powerful thing to intravenous administration. Also sticking shit up your ass reduces toxicity to the liver, because it bypasses the first mechanism of liver breakdown (similar to how IM is safer than oral steroids).

The only thing that would be difficult to control for, would be dosage. If it's anything like most other water-soluble drugs out there, then roughly 90% of it should be absorbed through your colon. But, since practically no research has been done on sticking oral steroids up your ass, who even really knows what proper dosage would be with rectal administration...
 
Why would somebody take that much Nolvadex a day? I mean its half life and elimination rate is ridiculously long, like 5 days or so, seems like she could have halved that dose and taken it every 2-3 days with less sides.

Thanks for the abstracts, I'm a real science-oriented person so I appreciate when people link me to medical journals and what not. I'll go check them out and read them right now.
The terminal elimination half-life of tamoxifen is 5-7days from what I've read and MOST studies on it i.e. large scale randomized clinical trials show a clinically significant dose to be 20mg. Couple that with the fact that in most people's views more equals better (very prevalent in the fitness and body building world) and you have a female bodybuilder dosing at 20-40mg/day for months lol. Se could have halved the dose and reduced the frequency but then would its clinical significance have been reduced as a result for her intended purpose? I think so but I still believe SERMs to not be effective for fat loss.

Your welcome and I'm a science person myself. I glanced through them quickly so how they relate, if at all, is up in the air but its what I found with a quick search hope they help.
 
Personally, I'm actually thinking about administering oral steroids rectally.... :laugh:

I MEAN THINK ABOUT IT!!!! Not only would it probably work, it will probably make the drug 3 times more effective, and reduce toxicity to the liver. I know that "bootybumping" works with virtually every psychoactive substance out there that is water-soluble, and is pretty much the next most powerful thing to intravenous administration. Also sticking shit up your ass reduces toxicity to the liver, because it bypasses the first mechanism of liver breakdown (similar to how IM is safer than oral steroids).

The only thing that would be difficult to control for, would be dosage. If it's anything like most other water-soluble drugs out there, then roughly 90% of it should be absorbed through your colon. But, since practically no research has been done on sticking oral steroids up your ass, who even really knows what proper dosage would be with rectal administration...

Careful with that thought process since its the same that the female bodybuilder used in the link I sent and you questioned it yourself lol. Rectal administration allows for substances to be quickly absorbed. An example is alcohol. It bypasses the liver when taken in the bootie and you can get drunk off one or two beers, but the chances of aclohol poisoning are raised exponentially as well. You're right no one knows the correct dishes for oral steroids administered rectally but I wouldn't want to be the guinea pig lol.

Judging from your reference to bootie bumps and your comments in the other thread, i feel safe in assuming you're into experimentation and Rec's so I just advise you to be very careful. I've been there before and some of the consequences do not show up immediately.
 
Careful with that thought process since its the same that the female bodybuilder used in the link I sent and you questioned it yourself lol. Rectal administration allows for substances to be quickly absorbed. An example is alcohol. It bypasses the liver when taken in the bootie and you can get drunk off one or two beers, but the chances of aclohol poisoning are raised exponentially as well. You're right no one knows the correct dishes for oral steroids administered rectally but I wouldn't want to be the guinea pig lol.

Judging from your reference to bootie bumps and your comments in the other thread, i feel safe in assuming you're into experimentation and Rec's so I just advise you to be very careful. I've been there before and some of the consequences do not show up immediately.

Is there even any medical information out there about oral bio-availability of prohormones and steroids? Because if most of these oral steroids have at least over 70% oral bioavailability then it would seem that rectal administration is pointless, aside from bypassing first liver mechanism.

Prohormones I'm certain, wouldn't work rectally, because AFAIK about how they work, they are converted into steroids in the body, which I'm only assuming takes place somewhere in the digestive system (similar to GBL and 14BDO's conversion to GHB). But hell, if you've got a hepatotoxic drug like Anadrol, it's worth researching whether rectal administration is an option.

Rectal administration does allow for quick absorption; it's about 10-15 minutes. It also makes many drugs last longer too (meth and oxycodone for instance, last longer than even intravenous administration), which equals: More drugs in your butt, more money in your wallet. :D Many drugs are far more effective rectally and are about 3 times stronger than when taken orally. This is true for MDMA, all stimulants, all thebaine and morphine-based opiates, etc. Whereas with other substances, inserting rectally doesn't make a lick of difference from oral administration (i.e. all benzo's, methadone, LSD, trazodone, etc.)

Okay, I am about to ask a really really dumb question, and this is purely out of curiosity and not something I actually plan on, or was even THINKING about doing... But what happens if you IV steroids? Would it even work? Would it get eliminated from the body very quickly? Would you feel a rush? See, I haven't researched much into how steroids work and don't have much first-hand experience... that's why I'm asking... Are there even any injectable steroids that aren't suspended in oil? I can see how the oil would pose a problem for IV use...
 
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