Problems with Exemestane / Aromasin Dosage

[GermBeast]

Hello,

I am going to run this protocol:
steroidology.com/forum/anabolic-steroid-forum/664646-cycling-beginners-guide-safe-androgen-use.html
Week 1-12 2x 250 mg Test E per week
Week 1-12 HCG 2x 250 iu per week
Last 10 Days of cycle 1000iu HCG everyday
Week 1-15 Exemestane 12.5mg everyday.

I am currently somewhere between 11 - 14% bodyfat.

So is 12.5mg Exemestane ED okay ?

I read that this is underdosed and Aromasin (Exemestane) should be dosed at 25mg 2x per day.
Source: forums.steroid.com/anabolic-steroids-questions-answers/531404-exemestane-underdosed-ai.html

Shall I just run the bigger 25mg ED dose until my bloodwork in week 4 and see how my estradiol level is ? (Risk of bad libido ?)And then maybe reducing to 12.5 ?
Or is it better to run smaller dosage first ? (Risk of gyno ?)

 

[SJC]

I don't really need more than 12.5 once a day on certain doses. EOD on others. There is nothing wrong with starting 12.5 ed then getting bloodwork at the 4-6 week mark.

 

[halfwit]

It's always best to start small and work your way up. Exemestane is pretty forgiving with estradiol, but a 50 dollar blood test will save you the trouble of finding out the hard way that you went too far.

 

[tbonexl]

You don't want to crash your estrogen! You'll be in big trouble then! Start with 12.5mgs per day...

 

[GermBeast]

Ok cool, the post in steroid forum just confused me:

We have a study here of males not taking testosterone , where they are taking 25-50mg/day and keeping estrogen levels low but within the clinical range. That is our exact goal! As I looked at this more and more it became apparent to me that my thoughts on dosage and administration frequency were in fact incorrect, Not only were they thoughts I subscribed too, but ones that are widely subscribed too. Why would we take less than these males when we have more androgens present? It makes no sense.Well in my opinion the answer is we shouldn't be. I decided I was going to be a guinea pig myself and play with exemestane dosages and get blood work my next cycle. I had become convinced and speculated the optimal protocol for my cycle,which would consist of a test base of 500mgs/week, would be 25mgs of exemestane/day. Broken up into 2 - 12,5 mg doses taken with fats.

Now had I not been browsing the various forums today I wouldn't be posting this. I came across a post of bloodwork from a gentleman, on cycle, 500mgs test/week , taking 25mgs exemestane per day, in 2 -12,5 mg doses with meals and his estrogen levels were safely within reference range!

That pretty much sealed it for me. I seriously think we are taking too little exemestane. I am going to do blood work when I go on cycle but at this point I dont think this is speculation. The study data backs it. The real world data backs it (good and bad), and you have a drug even at high doses that offers nothing in the way of traditional negative effects when lowering estrogen, positively impact some of those effects, and is very difficult to crash estrogen levels when taking.

I firmly believe that an increase in dosage and frequency of administration combined with taking with dietary fats will improve the effectiveness of exemestane. I really do believe that is the proper dose, taken in the proper way to ensure maximal effectiveness. It has taken some time for me to evolve this opinion and much discussion with some great guys here. Always learning.

So maybe he is wrong ? Opinions ?

 

[halfwit]

There's a very significant difference between taking an AI while on exogenous hormones and being natural. The HPTA loop is open when exogenous androgens are introduced; which is why you not only stop producing testosterone naturally, but also enables estradiol to be crashed due to this.

Exemestane or any AI should be introduced in a conservative dose, and adjusted with blood work. There isn't a set dose that works for everyone.

 

[ADenver]

I need 12.5 E3D on 500mg a week of Test E. Kept me in the middle. This is why bloodwork is important, it is very much a YMMV with your body.

 

[GermBeast]

Yea but it is hard to find my perfect dose on 12 week cycle ...

So shall I better start at 12.5mg EOD ? Because my BF will be under 12% ?

And does someone know how long it takes for aromasin to build up the blood levels ? I mean, how often can I do blood checks after changing the dosage ?

 

[halfwit]

Yea but it is hard to find my perfect dose on 12 week cycle ...

So shall I better start at 12.5mg EOD ? Because my BF will be under 12% ?

And does someone know how long it takes for aromasin to build up the blood levels ? I mean, how often can I do blood checks after changing the dosage ?

I would do at minimum 6.25mg ED. You can check about a week after to see how things are moving. It's not the concentration of the drug per se that matters in this instance, but how long it takes your body to eliminate the excess estradiol.

Just so you're not wasting money, I'd get a blood test before the cycle (ESPECIALLY if this is your first cycle), and a second one at around 5 weeks in. You can gauge the effectiveness of your AI and testosterone at the same time that way.