Question about free Estrogen

[vic305]

Is free estrogen what makes some women a little more sensitive/irritable when they ovulate?

Similarly, is free estrogen what makes men who don't manage their post cycle therapy (pct) correctly become sensitive enough to cry after watching a tv commercial?

Or, conversely, are these things the result of estrogen that binds to certain receptor cells in the brain?

 

[supergirl]

Both estrogen and progesterone if unbalanced contribute to a slew of side effects.
During a woman's cycle, days 7-14 (ovulation) estrogen is at its highest... Side effects usually are irritability, mood swings etc. Then from 14-24 progesterone is at its highest.. Side effects usually are depression, anxiety and bloating.

As per your question about men and pct.. I would attribute the "crying" to a drop in your testosterone levels more so than an increase in estrogen..

Numerous studies have been done on Estrogen as an antidepressant as it is understood to boost the level of neurotransmitters ..

Hope this helps answer your questions...

good luck
supes

 

[vic305]

Both estrogen and progesterone if unbalanced contribute to a slew of side effects.
During a woman's cycle, days 7-14 (ovulation) estrogen is at its highest... Side effects usually are irritability, mood swings etc. Then from 14-24 progesterone is at its highest.. Side effects usually are depression, anxiety and bloating.

As per your question about men and pct.. I would attribute the "crying" to a drop in your testosterone levels more so than an increase in estrogen..

Numerous studies have been done on Estrogen as an antidepressant as it is understood to boost the level of neurotransmitters ..

Hope this helps answer your questions...

good luck
supes

Thanks for the clarification, but are these the results of free estrogen or bound estrogen?

 

[supergirl]

Thanks for the clarification, but are these the results of free estrogen or bound estrogen?

Free: In men, when there is too little testosterone present, estrogen attaches to testosterone cell receptor sites throughout the body.

In women, Estrogen that is bound to protein is not as biologically active and cannot exert its effect, whereas the loosely-bound and free forms can.

Free or bioavailable hormone, that which will be delivered to the receptors in the tissues of the body does not go through the liver, thus free and not protein bound...


"The majority of hormones in the blood exist in one of two forms: free (5%) or protein bound (95%). While 95% of the hormones in the body are protein bound, it is only the 5% free hormones that are biologically active." Labrix News

supes